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ASTN2 encodes a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mouse. Additionally we are shipping Astrotactin 2 Proteins (9) and many more products for this protein.
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Mouse (Murine) Polyclonal Astrotactin 2 Primary Antibody for WB - ABIN1881076
Vrijenhoek, Buizer-Voskamp, van der Stelt, Strengman, Sabatti, Geurts van Kessel, Brunner, Ophoff, Veltman: Recurrent CNVs disrupt three candidate genes in schizophrenia patients. in American journal of human genetics 2008
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The expression of coding and non-coding genes with SAFB1 (show SAFB Antibodies) cross-link sites was altered by SAFB1 (show SAFB Antibodies) knockdown. The isoform-specific expression of neural cell adhesion molecule (show MCAM Antibodies) (NCAM1 (show NCAM1 Antibodies)) and ASTN2 was influenced by SAFB1 (show SAFB Antibodies).
Study found a significant association of ASTN2 genetic variants with age at onset in Alzheimer's disease in two independent samples together with in silico analysis that demonstrated potential role of ASTN2 in the pathogenesis of the disease
3' terminal ASTN2 deletions are significantly enriched in males with neurodevelopmental disorders, but not in females.
Single nucleotide polymorphism in ASTN2 gene is associated with cognition disorders.
This study has defined the transmembrane topology of mouse Astn2 and shown that this protein undergoes a single intramembrane proteolytic cleavage in the second of two transmembrane segments.
These experiments suggest that Astn2, an endosomal membrane protein, modulates Planar cell polarity signaling.
ASTN2 regulates the levels of ASTN1 (show ASTN1 Antibodies) in the plasma membrane and that the release of neuronal adhesions to the glial fiber during neuronal locomotion involves the intracellular trafficking of ASTN1 (show ASTN1 Antibodies).
This gene encodes a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mouse. A deletion at this locus has been associated with schizophrenia. Multiple transcript variants encoding different proteins have been found for this locus.
, bM243L4.1 (astrotactin 2)
, bM264P11.1 (astrotactin 2)
, bM383P24.1 (astrotactin 2)
, bM423P8.1 (astrotactin 2)
, bM452J22.1 (novel protein)
, bM468K2.1 (astrotactin 2)
, astrotactin 2-like