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The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Additionally we are shipping Ataxin 2-Binding Protein 1 Proteins (9) and Ataxin 2-Binding Protein 1 Kits (3) and many more products for this protein.
Showing 10 out of 97 products:
Chlamydomonas reinhardtii (C. reinhardtii) Polyclonal A2BP1 Primary Antibody for IF, WB - ABIN108467
Terauchi, Peers, Kobayashi, Niyogi, Merchant: Trophic status of Chlamydomonas reinhardtii influences the impact of iron deficiency on photosynthesis. in Photosynthesis research 2010
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Cow (Bovine) Polyclonal A2BP1 Primary Antibody for WB - ABIN2779139
Fogel, Wexler, Wahnich, Friedrich, Vijayendran, Gao, Parikshak, Konopka, Geschwind: RBFOX1 regulates both splicing and transcriptional networks in human neuronal development. in Human molecular genetics 2012
This study underlines that tightly regulated splicing is necessary for unconstrained cardiac function and renders the splicing regulator (show PTBP2 Antibodies) rbfox1 an interesting target for investigation in human heart failure and cardiomyopathy.
When the abundance of the FOX1 gene product is reduced, Chlamydomonas cells grow poorly in iron-deficient medium, but not in iron-replete medium, suggesting that FOX1-dependent iron uptake is a high-affinity pathway.
Report a 1.8 A X-ray structure of the free Fox-1 containing six distinct monomers. We use this and the nuclear magnetic resonance (NMR) structure of the Fox-1 protein/RNA complex for molecular dynamics (MD) analyses of the structured hydration. The individual monomers of the X-ray structure show diverse hydration patterns, however, MD excellently reproduces the most occupied hydration sites.
Copy-number variations are enriched for RBFOX1 and other neurodevelopmental genes in children with developmental coordination disorder.
We present a joint atomistic molecular dynamics (MD) and experimental study of two RRM-containing proteins bound with their single-stranded target RNAs, namely the Fox-1 and SRSF1 (show SRSF1 Antibodies) complexes.The simulations predict unanticipated specific participation of Arg142 at the protein-RNA interface of the SRFS1 complex, which is subsequently confirmed by NMR and ITC measurements
FGF12 (show FGF12 Antibodies), RBFOX1, and MIR302F could be important in human heterotaxy, because they were noted in multiple cases. Further investigation into genes involved in the NODAL, BMP, and WNT (show WNT2 Antibodies) body patterning pathways and into the dosage effects of FGF12 (show FGF12 Antibodies), RBFOX1, and MIR302F is warranted.
Data indicate that multiple rare, coding variants in RBFOX1 protein associated with reduced systolic blood pressure (SBP (show SHBG Antibodies)).
study identifies regulation of RNA splicing by RBFox1 as an important player in transcriptome reprogramming during heart failure that influence pathogenesis of the disease
The SNP rs1478697 in A2BP1 may be associated with antipsychotic induced weight gain induced by 8-week treatment with olanzapine.
Cytoplasmic Rbfox1 target mRNAs were enriched in genes involved in cortical development and autism
The Genome-wide association study showed a significant association for a variant within the RBFOX1 gene with generalized anxiety disorder.
Upon picrotoxin treatment, Rbfox1 expression was downregulated by miR (show MLXIP Antibodies)-129-5p, thereby allowing the repression of Atp2b4 (show ATP2B4 Antibodies) and Dcx (show DCX Antibodies).
Gain- and loss-of-function experiments demonstrated that Rbfox1 and Rbfox2 (show RBM9 Antibodies) cooperate in promoting Mef2D (show MEF2D Antibodies) splicing and subsequent myogenesis.
Rbfox1 regulates RNA splicing required for skeletal muscle structure and function.
Fox-1, expressed specifically in the neural cell stage, promoted Mef2c (show MEF2C Antibodies) exon beta inclusion via the GCAUG.
The results suggest that in neuronal tissues A2BP1 plays important roles, which are regulated in a spatiotemporal manner.
our results suggest that a component of FSHD pathogenesis may arise by over-expression of FRG1 (show FRG1 Antibodies), reducing Rbfox1 levels and leading to aberrant expression of an altered Calpain 3 (show CAPN3 Antibodies) protein through dysregulated splicing
Fox-1 splices mRNAs encoding proteins important in synaptic transmission and membrane excitation.
The splicing regulator (show PTBP2 Antibodies) Rbfox1 controls neuronal excitation in the mammalian brain.
These data indicate that A2BP1 mutations may clinically affect very selective forebrain neuron types from early periods of development.
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
RNA binding protein, fox-1 homolog (C. elegans) 1
, ataxin 2-binding protein 1
, RNA binding protein fox-1 homolog 1
, ataxin-2-binding protein 1
, fox-1 homolog A
, hexaribonucleotide-binding protein 1
, ataxin 2 binding protein 1
, hexaribonucleotide binding protein 1
, RNA binding protein, fox-1 homolog 1