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Atonal Homolog 7 (Drosophila) Proteins (ATOH7)

This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Additionally we are shipping ATOH7 Antibodies (65) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat ATOH7 ATOH7 365564  
ATOH7 53404 Q9Z2E5
ATOH7 220202 Q8N100
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Top ATOH7 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,280.67
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,330.17
Details

ATOH7 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human

More Proteins for Atonal Homolog 7 (Drosophila) (ATOH7) Interaction Partners

Zebrafish Atonal Homolog 7 (Drosophila) (ATOH7) interaction partners

  1. Atoh7 indirectly impacts amacrine-cell division modes to regulate the right number of Barhl2 (show BARHL2 Proteins)-expressing cells. Atoh7 itself influences the subtypes of Barhl2 (show BARHL2 Proteins)-dependent amacrine cells.

  2. Observations suggest that Irx2 (show IRX2 Proteins) functions downstream of irx1a (show IRX1 Proteins) to control shh (show SHH Proteins) expression in the retina. Study proposed a novel transcriptional cascade of ath5-irx1a (show IRX1 Proteins)-irx2a in the regulation of hedgehog (show SHH Proteins) waves during vertebrate retinal development.

  3. Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina.

Mouse (Murine) Atonal Homolog 7 (Drosophila) (ATOH7) interaction partners

  1. Pou4f2 (show POU4F2 Proteins) and Isl1 (show ISL1 Proteins), are sufficient to specify the retinal ganglion cell fate in ATOH7 deficient mice

  2. This study present evidence for a Pax6 (show PAX6 Proteins)-Atoh7-Eya2 (show EYA2 Proteins) pathway that acts downstream of Atoh7 but upstream of differentiation factor Pou4f2 (show POU4F2 Proteins).

  3. Notch (show NOTCH1 Proteins) signaling controls the overall tempo of retinogenesis through Atoh7 and Neurog2 (show NEUROG2 Proteins), by integrating cell fate specification, the wave of neurogenesis and the developmental status of cells ahead of this wave

  4. The level of basic helix-loop-helix factor Math5 expression may determine the ultimate number of retinal ganglion cells.

  5. Atoh7 acts dominantly in Neurod1-expressing retina progenitor cells to activate the retinal ganglion cell genetic program.

  6. Results suggest that Math5 is not sufficient to stimulate retinal ganglion cell (RGC)fate.

  7. new insights into Math5 function, ganglion cell development, and the mechanism of retinal fate determination were provided.

  8. The present data demonstrates that the loss of ganglion cells in the Math5(-/-) mice is associated with a lack of retinal vascular development.

  9. Report Math5 expression/function in retinal ganglion cells.

  10. Data suggest that Math5 regulates the generation of multiple retinal cell types via different mechanisms during retinogenesis.

Human Atonal Homolog 7 (Drosophila) (ATOH7) interaction partners

  1. Single nucleotide polymorphism in ATOH7 gene is associated with primary open angle glaucoma.

  2. The significant association of three common variants in TMCO1 (show TMCO1 Proteins), ATOH7, and CAV1 (show CAV1 Proteins) with primary open angle, primary angle closure, and pseudoexfoliation glaucoma was found in Pakistani cohorts.

  3. Mutations within the ATOH7 gene are not implicated in the pathogenesis of optic nerve hypoplasia in our patient cohort.

  4. This study finds that ATOH7 is associated with optic disc size but not independently with cup/disk ratio.

  5. a bHLH mutation in ATOH7 causes recessive persistent hyperplasia of the primary vitreous

  6. findings document Mendelian mutations within ATOH7 and imply a role for this molecule in the development of structures at the front as well as the back of the eye; study provides further insights into the function of ATOH7, especially its importance in retinal vascular development and hyaloid regression

  7. combination of ATOH7 and RFTN1 (show RFTN1 Proteins) SNPs increased risk to POAG, indicating their diversified effects in the complex genetics of glaucoma.

  8. Report Math5 expression/function in retinal ganglion cells.

  9. ATOH7 is significantly associated with open-angle glaucoma.

  10. Polymorphisms of ATOH7, TGFBR3 (show TGFBR3 Proteins) and CARD10 (show CARD10 Proteins) influence the size of optic disc area.

ATOH7 Protein Profile

Protein Summary

This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Studies in mice suggest that this gene plays a central role in retinal ganglion cell and optic nerve formation. Mutations in this gene are associated with nonsyndromic congenital retinal nonattachment.

Gene names and symbols associated with ATOH7

  • atonal homolog 7 (Drosophila) (Atoh7)
  • atonal homolog 7 (Drosophila) (ATOH7)
  • atonal homolog 7 (LOC100230256)
  • atonal homolog 7 (LOC100342736)
  • atonal homolog 7 (atoh7)
  • ATH5 protein
  • ATOH7 protein
  • bHLHa13 protein
  • Math5 protein
  • zath5 protein

Protein level used designations for ATOH7

atonal homolog 7 , atonal homolog 7 (Drosophila) , atonal homolog 5 , helix-loop-helix protein zATH-5 , lak , lakritz , protein atonal homolog 5 , protein atonal homolog 7 , protein lakritz , helix-loop-helix protein mATH-5 , class A basic helix-loop-helix protein 13 , helix-loop-helix protein hATH-5 , Atonal Homolog 5 , atonal transcription factor homologue , cATH5 , helix-loop-helix protein cATH-5

GENE ID SPECIES
365564 Rattus norvegicus
466090 Pan troglodytes
489014 Canis lupus familiaris
539903 Bos taurus
100230256 Taeniopygia guttata
100342736 Oryctolagus cuniculus
58216 Danio rerio
53404 Mus musculus
220202 Homo sapiens
395388 Gallus gallus
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