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BLK encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. Additionally we are shipping BLK Proteins (12) and BLK Kits (6) and many more products for this protein.
Showing 10 out of 180 products:
Human Monoclonal BLK Primary Antibody for ICC, FACS - ABIN968983
Yang, Ng, Zhao, Hirankarn, Lau, Mok, Chan, Wong, Lee, Mok, Wong, Avihingsanon, Lee, Ho, Lee, Wong, Lau: Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese. in Genes and immunity 2009
Show all 3 references for ABIN968983
Human Polyclonal BLK Primary Antibody for EIA, IHC (p) - ABIN4620391
Islam, Rabbani, Larsson, Sanders, Smith: Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk. in Journal of immunology (Baltimore, Md. : 1950) 1995
Show all 2 references for ABIN4620391
Mouse (Murine) Polyclonal BLK Primary Antibody for WB - ABIN222964
Chen, Huang, Wang: Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. in Blood 2007
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Human Polyclonal BLK Primary Antibody for IHC (p), WB - ABIN392087
Drebin, Hartzell, Griffin, Campbell, Niederhuber: Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk). in Oncogene 1995
Show all 2 references for ABIN392087
Human Monoclonal BLK Primary Antibody for ELISA, IHC - ABIN2869210
Tretter, Ross, Dordai, Desiderio: Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk. in The Journal of experimental medicine 2003
Chicken Polyclonal BLK Primary Antibody for WB - ABIN2782461
Cho, Akbarali, Zerbini, Gu, Boltax, Wang, Oettgen, Zhang, Libermann: Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. in The Journal of biological chemistry 2004
our study reveals a previously unappreciated role of reduced BLK (show BIK Antibodies) expression on extraperitoneal accumulation of B1a cells in mice, as well as the presence of IgG autoantibodies and B1-like cells in humans.
BLK (show BIK Antibodies) risk alleles confer susceptibility to systemic lupus erythematosus through the dysregulation of a proinflammatory cytokine network.
this study has revealed a previously unappreciated role for Blk (show BIK Antibodies) in the development and activation of MZ B cells
BCR-ABL (show ABL1 Antibodies) downregulates the Blk (show BIK Antibodies) gene (encoding B-lymphoid kinase) through c-Myc (show MYC Antibodies) in leukemic stem cells in chronic myeloid leukemia (show BCL11A Antibodies)
Data suggest a role of tyrosine kinase (show TYRO3 Antibodies) Btk (show BTK Antibodies) in the regulation of immune cell unctions and innate inflammatory response.
Analysis of Blk (show BIK Antibodies)-deficient mice reveals that Blk (show BIK Antibodies) is required for the development of IL-17 (show IL17A Antibodies)-producing gammadelta T cell effectors and plays a role in regulating thymus cellularity during ontogeny.
sustained activation of Blk (show BIK Antibodies) induces responses normally associated with the pre-BCR (show BCR Antibodies).
Blk (show BIK Antibodies), being exceptionally highly expressed in the initial segment, is suggested to have a role in the differentiation of this segment of the epididymis.
The systemic lupus erythematosus variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 (show BANK1 Antibodies) through impairment of the SH3 domain (show ITSN1 Antibodies) function.
Report a novel BLK gene variant in common variable immunodeficiency-patients that causes suppressed B-cell proliferation and reduced ability of B-cells to elicit antigen-specific CD4 (show CD4 Antibodies)(+) T-cell responses.
A major mechanism underlying the BLK association with autoimmune disease involves lowered thresholds for basal B cell receptor signaling, enhanced B cell-T cell interactions, and altered patterns of isotype switching.
our study reveals a previously unappreciated role of reduced BLK expression on extraperitoneal accumulation of B1a cells in mice, as well as the presence of IgG autoantibodies and B1-like cells in humans.
Results support previous findings that vaiants in the RHOB and FAM167A-BLK genes may be associated with susceptibility to systemic sclerosis.
These results place Blk upstream of the p190RhoGAP (show GRLF1 Antibodies)-RhoA (show RHOA Antibodies) pathway in Galpha13 (show GNA13 Antibodies)-activated cells, overall representing an opposing signaling module during CXCL12 (show CXCL12 Antibodies)-triggered invasion.
Report role of BLK genetic variants in confering risk of systemic lupus erythematosus in Chinese population.
The observations suggested that C8orf13-BLK, in combination with STAT4 (show STAT4 Antibodies), plays a pivotal role in creating genetic susceptibility to polymyositis/dermatomyositis in Japanese individuals.
B-lymphoid tyrosine kinase (Blk) is an oncogene (show RAB1A Antibodies) and a potential target for therapy with dasatinib in cutaneous T-cell lymphoma
results demonstrated that both lupus-associated functional variants contribute to the autoimmune disease association by modulating transcription of BLK in B cells and thus potentially altering immune responses
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors.
B lymphoid kinase
, tyrosine-protein kinase Blk
, B lymphoid tyrosine kinase
, tyrosine-protein kinase Blk-like
, b lymphocyte kinase
, BLK nonreceptor tyrosine kinase