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BLK antibody (B Lymphoid Tyrosine Kinase)

Details for Product anti-BLK Antibody No. ABIN968983, Supplier: Log in to see
Antigen
  • bltk
  • MODY11
  • si:dkey-33i22.2
  • zgc:136231
Reactivity
Human
171
48
35
2
1
1
1
Host
Mouse
89
74
13
Clonality (Clone)
Monoclonal ()
Conjugate
This BLK antibody is un-conjugated
5
5
5
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Flow Cytometry (FACS), ELISA, Western Blotting (WB)
138
96
74
18
12
8
7
7
5
4
3
Supplier
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Immunogen Purified recombinant fragment of human BLK expressed in E. coli.
Clone 1-00E-06
Isotype IgG1
Purification Ascites
Alternative Name BLK (BLK Antibody Abstract)
Background Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development . Activation of B cells by various ligands is accompanied by activation of Blk . It has been suggested that Blk is involved in the control of B cell differentiation and proliferation . Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis . Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response .
Molecular Weight 58 kDa
Gene ID 640
HGNC 640
Research Area Apoptosis/Necrosis
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Flow Cytometry (FACS) image for anti-BLK antibody (B Lymphoid Tyrosine Kinase) (ABIN968983) Figure 1: Flow cytometric analysis of HL-60 cells using BLK mouse mAb (green) and neg...
Immunocytochemistry (ICC) image for anti-BLK antibody (B Lymphoid Tyrosine Kinase) (ABIN968983) Figure 2: Immunofluorescence analysis of Hela cells using BLK mouse mAb (green) . Blu...
Western Blotting (WB) image for anti-BLK antibody (B Lymphoid Tyrosine Kinase) (ABIN968983) Figure 3: Western blot analysis using BLK mAb against HEK293 (1) and BLK (AA: 2-200) ...
Product cited in: Yang, Ng, Zhao, Hirankarn, Lau, Mok, Chan, Wong, Lee, Mok, Wong, Avihingsanon, Lee, Ho, Lee, Wong, Lau: "Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese." in: Genes and immunity, Vol. 10, Issue 3, pp. 219-26, 2009 (PubMed).

Borowiec, Liew, Thompson, Boonyasrisawat, Hu, Mlynarski, El Khattabi, Kim, Marselli, Rich, Krolewski, Bonner-Weir, Sharma, Sale, Mychaleckyj, Kulkarni, Doria: "Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 34, pp. 14460-5, 2009 (PubMed).

Hom, Graham, Modrek, Taylor, Ortmann, Garnier, Lee, Chung, Ferreira, Pant, Ballinger, Kosoy, Demirci, Kamboh, Kao, Tian, Gunnarsson, Bengtsson, Rantapää-Dahlqvist, Petri, Manzi, Seldin, Rönnblom et al.: "Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. ..." in: The New England journal of medicine, Vol. 358, Issue 9, pp. 900-9, 2008 (PubMed).