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The protein encoded by BANK1 is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. Additionally we are shipping BANK1 Antibodies (24) and many more products for this protein.
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Following CpG stimulation of B-cells, BANK1 loss reduced p38 (show CRK Proteins) phosphorylation (but not ERK (show EPHB2 Proteins) or JNK (show MAPK8 Proteins)), IL-6 (show IL6 Proteins) secretion, & MNK1 (show MKNK1 Proteins)/2 and eIF4E (show EIF4E Proteins) phosphorylation. It had no effect on IL-6 (show IL6 Proteins) mRNA stability. BANK1 does not affect release of eIF4E (show EIF4E Proteins) by phospho-4E-BP1 (show EIF4EBP1 Proteins).
BANK attenuates CD40 (show CD40 Proteins)-mediated Akt (show AKT1 Proteins) activation, thereby preventing hyperactive B cell responses.
The systemic lupus erythematosus variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function.
Data show that single-nucleotide polymorphism rs3733197 located in the coding region of BANK1 (B-cell scaffold protein with ankyrin repeats 1) was significantly associated with serum LDL cholesterols.
Authors identified a novel balanced reciprocal translocation, t(4;14)(q24;q32.) Sequence analysis identified the partner gene as BANK1.
Our study confirms evidence for epistasis between BLK (show BLK Proteins) and BANK1 in systemic lupus erythematosis from a Chinese population for the first time.
Our findings suggest the existence of association between BANK1 gene and autoimmune thyroid diseases
BANK1 and IL15 (show IL15 Proteins) as new T1D genetic susceptibility factors.
BANK1 and BLK (show BLK Proteins) have roles in B-cell signaling through phospholipase C gamma 2 (show PLCG2 Proteins)
SNPs of the FAM167A-BLK region, but not the BANK1 SNPs, were associated with the development of primary Sjogren's syndrome in Han Chinese.
This study confirms BANK1 as an RA susceptibility gene and for the first time provides evidence for epistasis between BANK1 and BLK (show BLK Proteins) in RA.
This study did not reveal a major role for BANK1 in humoral autoimmunity in chronic arthritis.
The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
B-cell scaffold protein with ankyrin repeats
, B-cell scaffold protein with ankyrin repeats 1
, B-cell scaffold protein with ankyrin repeats 1 delta 2 transcript
, B-cell scaffold protein with ankyrin repeats-like
, b-cell scaffold protein with ankyrin repeats-like