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The protein encoded by BAIAP2 has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. Additionally we are shipping BAIAP2 Proteins (11) and BAIAP2 Kits (1) and many more products for this protein.
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Human Monoclonal BAIAP2 Primary Antibody for WB - ABIN1882211
Miyahara, Okamura-Oho, Miyashita, Hoshika, Yamada: Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein. in Journal of human genetics 2003
Show all 3 Pubmed References
BAIAP2 is a candidate gene for mediating dendritic spine density abnormalities in schizophrenia. Data suggest that altered DNA methylation (show HELLS Antibodies) in schizophrenia may be a mechanism for schizophrenia-related dendritic spine density reductions.
Overexpression of LIN7 or IRSp53 did not prevent the formation of hyperfused mitochondria in cells coexpressing the Drp1 (show CRMP1 Antibodies) K38A mutant, thus suggesting that LIN7-IRSp53 complex requires functional Drp1 (show CRMP1 Antibodies) to regulate mitochondrial morphology.
Results suggest the hypothesis that defective actin/membrane modulation in IRSp53-deficient dendritic spines may lead to social and cognitive deficits through N-methyl-d-aspartate receptor (show GRIN1 Antibodies) dysfunction.
determined the alpha-synuclein (show SNCA PLURAL_@19415@)-binding domain of beta-III tubulin (show TUBB PLURAL_@19415@) and demonstrated that a short fragment containing this domain can suppress alpha-synuclein (show SNCA PLURAL_@19415@) accumulation in the primary cultured cells
BAIAP2 is related to emotional modulation of human memory strength.
These above results indicated the possible involvement of BAIAP2 in the etiology of attention deficit disorder with hyperactivity, especially ADHD-I.
IRSp53 adopts a closed inactive conformation that opens synergistically with the binding of human Cdc42 (show CDC42 Antibodies) to the CRIB (show SCRIB Antibodies)-PR and effector proteins, such as the tumor-promoting factor Eps8 (show EPS8 Antibodies), to the SH3 domain (show ITSN1 Antibodies).
LIN7 is a novel regulator of IRSp53.
mDia1 and WAVE2 (show WASF2 Antibodies) are important Src (show SRC Antibodies) homology 3 domain partners of IRSp53 in forming filopodia.
Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli
CDC42 activation inhibits this activity and promotes IRSp53-dependent recruitment and clustering of VASP to drive actin assembly.
VASP (show VASP Antibodies) physically interacted with IRSp53 in NIH-Src (show SRC Antibodies) cells and was essential for podosome formation.
propose that IRSp53 is a negative regulator of myogenic differentiation which correlates with the observed down regulation of IRSp53 expression during myoblast differentiation to myotubes
IRSp53, through its interaction with Eps8 (show EPS8 Antibodies), not only affects cell migration but also dictates cellular growth in cancer cells.
IRSp53 and spinophilin (show PPP1R9B Antibodies) regulate localized Rac (show AKT1 Antibodies) activation by T-lymphocyte invasion and metastasis protein 1
In cells spread well on a laminin substrate, IRSp53 was localised at the tips of both lamellipodia and filopodia and in in living cells during protrusion.
Rac1, along with IRSp53 and Abi1 (show ABI1 Antibodies), is involved in a more complex and tight regulation of WAVE2 (show WASF2 Antibodies) than one operating solely through membrane localization.
Consistent with altered synaptic plasticity, IRSp53-deficient mice exhibit cognitive deficits in the contextual fear-conditioning paradigm
Formation of filopodia is dependent on the Rho family GTPase Cdc42 (show CDC42 Antibodies) and the Cdc42 effector (show FNBP1L Antibodies) IRSp53 (Baiap2).
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
, brain-specific angiogenesis inhibitor 1-associated protein 2
, fas ligand-associated factor 3
, insulin receptor substrate p53/p58
, insulin receptor substrate protein of 53 kDa
, insulin recptor substrate p53
, BAI1-associated protein 2
, BAI-associated protein 2
, brain-specific angiogenesis inhibitor 1-associated protein 2-like
, insulin receptor substrate p53
, insulin receptor tyrosine kinase 53 kDa substrate
, insulin receptor substrate 53
, insulin receptor tyrosine kinase substrate protein p53