BAI1-Associated Protein 2 Proteins (BAIAP2)

The protein encoded by BAIAP2 has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. Additionally we are shipping BAIAP2 Antibodies (125) and BAIAP2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BAIAP2 10458 Q9UQB8
BAIAP2 108100 Q8BKX1
Rat BAIAP2 BAIAP2 117542 Q6GMN2
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Top BAIAP2 Proteins at antibodies-online.com

Showing 6 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$460.85
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

BAIAP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine)

More Proteins for BAI1-Associated Protein 2 (BAIAP2) Interaction Partners

Human BAI1-Associated Protein 2 (BAIAP2) interaction partners

  1. BAIAP2 is a candidate gene for mediating dendritic spine density abnormalities in schizophrenia. Data suggest that altered DNA methylation (show HELLS Proteins) in schizophrenia may be a mechanism for schizophrenia-related dendritic spine density reductions.

  2. Overexpression of LIN7 or IRSp53 did not prevent the formation of hyperfused mitochondria in cells coexpressing the Drp1 K38A mutant, thus suggesting that LIN7-IRSp53 complex requires functional Drp1 to regulate mitochondrial morphology.

  3. Results suggest the hypothesis that defective actin/membrane modulation in IRSp53-deficient dendritic spines may lead to social and cognitive deficits through N-methyl-d-aspartate receptor (show GRIN1 Proteins) dysfunction.

  4. determined the alpha-synuclein-binding domain of beta-III tubulin and demonstrated that a short fragment containing this domain can suppress alpha-synuclein accumulation in the primary cultured cells

  5. BAIAP2 is related to emotional modulation of human memory strength.

  6. These above results indicated the possible involvement of BAIAP2 in the etiology of attention deficit disorder with hyperactivity, especially ADHD-I.

  7. IRSp53 adopts a closed inactive conformation that opens synergistically with the binding of human Cdc42 to the CRIB-PR and effector proteins, such as the tumor-promoting factor Eps8, to the SH3 domain.

  8. LIN7 is a novel regulator of IRSp53.

  9. mDia1 and WAVE2 (show WASF2 Proteins) are important Src (show SRC Proteins) homology 3 domain partners of IRSp53 in forming filopodia.

  10. Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli

Mouse (Murine) BAI1-Associated Protein 2 (BAIAP2) interaction partners

  1. CDC42 activation inhibits this activity and promotes IRSp53-dependent recruitment and clustering of VASP to drive actin assembly.

  2. VASP (show VASP Proteins) physically interacted with IRSp53 in NIH-Src (show SRC Proteins) cells and was essential for podosome formation.

  3. propose that IRSp53 is a negative regulator of myogenic differentiation which correlates with the observed down regulation of IRSp53 expression during myoblast differentiation to myotubes

  4. mDia1 and WAVE2 (show WASF2 Proteins) are important Src (show SRC Proteins) homology 3 domain partners of IRSp53 in forming filopodia.

  5. IRSp53, through its interaction with Eps8 (show EPS8 Proteins), not only affects cell migration but also dictates cellular growth in cancer cells.

  6. IRSp53 and spinophilin (show PPP1R9B Proteins) regulate localized Rac (show AKT1 Proteins) activation by T-lymphocyte invasion and metastasis protein 1

  7. In cells spread well on a laminin substrate, IRSp53 was localised at the tips of both lamellipodia and filopodia and in in living cells during protrusion.

  8. Rac1, along with IRSp53 and Abi1 (show ABI1 Proteins), is involved in a more complex and tight regulation of WAVE2 (show WASF2 Proteins) than one operating solely through membrane localization.

  9. Consistent with altered synaptic plasticity, IRSp53-deficient mice exhibit cognitive deficits in the contextual fear-conditioning paradigm

  10. Formation of filopodia is dependent on the Rho family GTPase Cdc42 (show CDC42 Proteins) and the Cdc42 effector (show FNBP1L Proteins) IRSp53 (Baiap2).

BAIAP2 Protein Profile

Protein Summary

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with BAIAP2

  • BAI1 associated protein 2 (BAIAP2)
  • BAI1-associated protein 2 (baiap2)
  • brain-specific angiogenesis inhibitor 1-associated protein 2 (Baiap2)
  • BAI1-associated protein 2 (Baiap2)
  • BAI1 associated protein 2 (Baiap2)
  • BAIAP2 protein
  • BAP2 protein
  • DKFZp470L1727 protein
  • FLAF3 protein
  • Irsp53 protein
  • IRSP53S protein
  • R75030 protein

Protein level used designations for BAIAP2

IRS-58 , IRSp53/58 , brain-specific angiogenesis inhibitor 1-associated protein 2 , fas ligand-associated factor 3 , insulin receptor substrate p53/p58 , insulin receptor substrate protein of 53 kDa , insulin recptor substrate p53 , BAI1-associated protein 2 , BAI-associated protein 2 , brain-specific angiogenesis inhibitor 1-associated protein 2-like , insulin receptor substrate p53 , insulin receptor tyrosine kinase 53 kDa substrate , insulin receptor substrate 53 , insulin receptor tyrosine kinase substrate protein p53

GENE ID SPECIES
10458 Homo sapiens
403473 Canis lupus familiaris
422077 Gallus gallus
454951 Pan troglodytes
507837 Bos taurus
100158528 Xenopus (Silurana) tropicalis
100172379 Pongo abelii
100428388 Macaca mulatta
108100 Mus musculus
117542 Rattus norvegicus
100734135 Cavia porcellus
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