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The protein encoded by BCOR was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. Additionally we are shipping BCOR Proteins (5) and BCOR Kits (2) and many more products for this protein.
Showing 10 out of 57 products:
Human Polyclonal BCOR Primary Antibody for IP, WB - ABIN4283798
Dietrich, Lerdrup, Landt, Agrawal-Singh, Bak, Tommerup, Rappsilber, Södersten, Hansen: REST-mediated recruitment of polycomb repressor complexes in mammalian cells. in PLoS genetics 2012
Human Polyclonal BCOR Primary Antibody for ELISA, WB - ABIN565785
Sánchez, Sánchez, Demmers, Rodriguez, Strouboulis, Vidal: Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. in Molecular & cellular proteomics : MCP 2007
Human Polyclonal BCOR Primary Antibody for ELISA, WB - ABIN185043
Tang, Dowbenko, Jackson, Toney, Lewin, Dent, Lasky: The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. in The Journal of biological chemistry 2002
Show all 2 Pubmed References
we report recurrent BCOR exon 16 internal tandem duplications and YWHAE (show YWHAE Antibodies)-NUTM2B fusions in half of infantile soft tissue undifferentiated round cell sarcoma and most primitive myxoid mesenchymal tumor of infancy cases, but not in other pediatric sarcomas.
All small blue round cell tumors (SBRCTs) with BCOR-MAML3 (show MAML3 Antibodies) and BCOR-CCNB3 (show CCNB3 Antibodies) fusions, as well as most with BCOR internal tandem duplications (93%), and all clear cell sarcoma of kidney showed strong and diffuse nuclear BCOR immunoreactivity.
we find that ESS with ZC3H7B (show ZC3H7B Antibodies)-BCOR fusion constitutes a novel type of high-grade endometrial stromal sarcoma and shares significant morphologic overlap with myxoid leiomyosarcoma
We report the case of a 7-month-old girl with atypical oculo-facio-cardio-dental syndrome (OFCD). A novel de novo pathogenic mutation in the BCL6 (show BCL6 Antibodies) interacting co-repressor gene (BCOR) (c.4540C>T; p.Arg1514*), was identified on the X chromosome
ZC3H7B (show ZC3H7B Antibodies)-BCOR and MEAF6 (show MEAF6 Antibodies)-PHF1 (show PHF1 Antibodies) fusions occurred predominantly in S100 protein-negative and malignant OFMT.
Given the high frequency and pattern of aberration, BCOR is likely to play an important role in ENKTL pathogenesis as a tumor suppressor gene
Data suggest the detection of the partial duplication inside exon 15 of proto-oncogene (show RAB1A Antibodies) protein BCOR as part of the diagnostic process of pediatric kidney tumors.
Report mutually exclusive BCOR internal tandem duplications and YWHAE (show YWHAE Antibodies)-NUTM2 fusions in clear cell sarcoma of kidney.
The present study further expands the genetic spectrum of small blue round cell tumors, with 2 novel fusions, BCOR-MAML3 (show MAML3 Antibodies) and ZC3H7B (show ZC3H7B Antibodies)-BCOR, identified
Somatic internal tandem duplications (ITDs) clustering in the C terminus of BCOR were found in 85% of pediatric clear cell sarcoma of the kidney. Mutant BCOR transcripts and proteins are markedly upregulated in ITD-positive tumours.
results provide the first evidence of a tumor suppressor role for BCOR in the pathogenesis of T lymphocyte malignancies
Data show that BCL6 interacting corepressor Bcor Is Specifically Down-regulated by Activin (show Actbeta Antibodies) Signaling in trophoblast stem cells (TSCs).
T cell-expressed BCOR is critical for optimal GC-Tfh cell differentiation and humoral immunity.
IRF8 (show IRF8 Antibodies) pairs with BCL6 co-repressor BCOR in the nucleus to enhance its transcriptional repressive activity.
Results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development.
Study isolated an Fbxl10/Jhdm1B (show KDM2B Antibodies) complex by Study using a high throughput proteomics approach identified interactors with Rnf2 (show RNF2 Antibodies) including Fbxl10/Jhdm1B (show KDM2B Antibodies), casein kinase subunits, and the BcoR corepressor
Bcor plays a role in differentiation of multiple tissue lineages during early embryonic development.
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.
, BCL6 co-repressor
, BCL-6 interacting corepressor
, Bcl6 interacting corepressor