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BMP Binding Endothelial Regulator Proteins (BMPER)

BMPER encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. Additionally we are shipping BMPER Antibodies (30) and BMPER Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BMPER 168667 Q8N8U9
BMPER 73230 Q8CJ69
Rat BMPER BMPER 300455  
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Top BMPER Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

BMPER Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for BMP Binding Endothelial Regulator (BMPER) Interaction Partners

Fruit Fly (Drosophila melanogaster) BMP Binding Endothelial Regulator (BMPER) interaction partners

  1. The bone morphogenetic protein- binding protein Cv-2 negatively regulates bone morphogenetic protein signaling.

  2. Cv-2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling.

Zebrafish BMP Binding Endothelial Regulator (BMPER) interaction partners

  1. The NMR structure of the Danio rerio CV2 VWC1 domain in its unbound state shows the key features for high affinity binding to BMP-2 (show BMP4 Proteins) are a pre-oriented peptide loop.

  2. Crossveinless 2 functions in a positive-feedback loop to locally enhance BMP activity and is required for neural crest fate determination.

  3. LRP1 (show LRP1 Proteins) acts as an endocytic receptor for Bmper and a coreceptor of Bmp4 (show BMP4 Proteins) to mediate the endocytosis of the Bmper/Bmp4 (show BMP4 Proteins) signaling complex.

  4. Binding of CV2 to Chordin (show CHRD Proteins) promotes BMP-2 (show BMP4 Proteins) signaling.

  5. Cvl2 was identified as an essential pro-bone morphogenetic protein factor during zebrafish embryogenesis.

  6. Bmper is a conserved regulator of hematopoietic and vascular development in zebrafish.

  7. Initial crystallographic analysis suggests that a complete binary complex consisting of one BMP2 (show BMP4 Proteins) dimer bound to two crossveinless 2 (CV2) von Willebrand type C (VWC1) domains is present in the asymmetric unit.

  8. The structure of the complex between CV-2 Von Willebrand factor (show VWF Proteins) type C (VWC) domain 1 and BMP-2 (show BMP4 Proteins), is reported.

Xenopus laevis BMP Binding Endothelial Regulator (BMPER) interaction partners

  1. CV2/Chordin interaction may help coordinate bone morphogenetic protein (BMP) diffusion to the ventral side of the embryo, ensuring that BMPs liberated from Chordin inhibition by tolloid proteolysis cause peak signaling levels.

Human BMP Binding Endothelial Regulator (BMPER) interaction partners

  1. BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis.

  2. BMPER-dependent pathway involved in high glucose induced alkaline phosphatase expression in vascular smooth muscle cells.

  3. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 (show THBS1 Proteins) and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis.

  4. these results suggest that BMPER and Tsg maintain a fine-tuned equilibrium that controls BMP pathway activity and is necessary for vascular cell homeostasis.

  5. BMPER is a novel regulator of the osteoblast-like differentiation of HCASMCs.

  6. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis.

  7. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER.

  8. Mutual regulation by BMP-9 (show GDF2 Proteins) and CV2 is essential in regulating the development of the vascular endothelium.

  9. Diaphonospondylodysostosis is caused by loss of BMPER function.

  10. BMPER-mediated signaling plays an essential role in vertebral segmentation early in human development, while defects in BMPER produce Diaphanospondylodysostosis.

Cow (Bovine) BMP Binding Endothelial Regulator (BMPER) interaction partners

  1. Results identified variant SNPs in BMPER gene associated with phenotypic variation in cattle that can be used as genetic markers for breeding.

Pig (Porcine) BMP Binding Endothelial Regulator (BMPER) interaction partners

  1. BMPER promoter polymorphisms have an effect on the intramuscular fat deposition in longissimus dorsi muscle content.

Mouse (Murine) BMP Binding Endothelial Regulator (BMPER) interaction partners

  1. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 (show THBS1 Proteins) and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis.

  2. BMPER-induced BMP signaling promotes coronary artery remodeling.

  3. BMPER appears to play a role in regulating both vessel density and cardiac development

  4. BMPER expression is decreased following lung injury, which in turn impairs epithelial integrity, characterized by reduction of E-cadherin (show CDH1 Proteins) and epithelial leakage in vitro and in vivo.

  5. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis.

  6. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER.

  7. Bmper may play an important role in suppressing hepcidin (show HAMP Proteins) production in hypotransferrinemic mice.

  8. BMP modulator BMPER is a new protective regulator of vascular inflammation that modulates leukocyte adhesion and migration in vitro and in vivo.

  9. BMPER is important in the regulation of BMP signaling and revascularization in the hypoxic retina.

  10. The data indicate a role for CV2 and Chd in the establishment of the vertebral morphogenetic field through the long-range relocalization of Chd/BMP complexes.

BMPER Protein Profile

Protein Summary

This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis.

Gene names and symbols associated with BMPER

  • BMP-binding endothelial regulator precursor protein (LOC100225434)
  • BMP-binding endothelial regulator precursor protein (LOC100349327)
  • crossveinless 2 (cv-2)
  • BMP binding endothelial regulator (BMPER)
  • BMP binding endothelial regulator (bmper)
  • crossveinless 2 (cv2)
  • BMP-binding endothelial regulator (Bmper)
  • 3110056H04Rik protein
  • BMPER protein
  • CG15671 protein
  • Crim3 protein
  • CT35855 protein
  • CV-2 protein
  • cv2 protein
  • cv 2 protein
  • cvl2 protein
  • Dmel\\CG15671 protein
  • id:ibd5071 protein
  • RGD1563373 protein

Protein level used designations for BMPER

BMP-binding endothelial regulator precursor protein , CG15671-PA , crossveinless-2 , cv-2-PA , BMP binding endothelial regulator , crossveinless 2 , BMP-binding endothelial regulator protein-like , BMP-binding endothelial regulator protein , cv2 , bone morphogenetic protein-binding endothelial cell precursor-derived regulator , hCV2

GENE ID SPECIES
100225434 Taeniopygia guttata
100349327 Oryctolagus cuniculus
45280 Drosophila melanogaster
463344 Pan troglodytes
733449 Xenopus (Silurana) tropicalis
100070275 Equus caballus
100303516 Saccoglossus kowalevskii
100415378 Callithrix jacchus
100472873 Ailuropoda melanoleuca
100605182 Nomascus leucogenys
338246 Danio rerio
734166 Xenopus laevis
420744 Gallus gallus
168667 Homo sapiens
534101 Bos taurus
475280 Canis lupus familiaris
100525197 Sus scrofa
73230 Mus musculus
300455 Rattus norvegicus
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