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The protein encoded by BAP1 localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). Additionally we are shipping BAP1 Antibodies (126) and BAP1 Proteins (7) and many more products for this protein.
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the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure
BAP1(+/-) mice exposed to low-dose asbestos fibers showed an altered peritoneal inflammatory response and higher levels of pro-tumorigenic alternatively polarized M2 macrophages, and lower cytokine levels. They had a higher incidence of mesothelioma.
Bap1 loss led to a fully penetrant myeloproliferative disease with splenomegaly, leukocytosis, anemia and progenitor expansion via alterations in histone methylation and gene expression.
INO80 (show INO80 ELISA Kits) is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells
Both Vhl (show VHL ELISA Kits) and Bap1 are required for kidney function. Inactivation of Bap1 in neprhon progenitor cells causes renal failure earlier than Vhl (show VHL ELISA Kits) inactivation. Bap1 is also a stronger tumor suppressor gene than Vhl (show VHL ELISA Kits) in the kidney.
Drawing parallels to human disease, these unbiased genetic findings indicate that BAP1 mutation carriers are predisposed to the tumorigenic effects of asbestos and suggest that high penetrance of mesothelioma requires such environmental exposure.
Cx32 (show GJB1 ELISA Kits) expression is in part related to induction of tight junctions through modulation of Magi1 (show CNKSR3 ELISA Kits) expression in an immortalized hepatic cell line.
ARIP1 (show MAGI2 ELISA Kits) and ARIP2 (show SYNJ2BP ELISA Kits) are co-expressed in some nerve cells and their biological activities are distinct.
results identify a potent tumor suppressor function for BAP1 in myeloid neoplasia; propose that BAP1 forms a core complex with HCF-1 (show HCFC1 ELISA Kits) and OGT (show OGT ELISA Kits) that can differentially recruit additional histone-modifying enzymes to regulate gene expression and preserve norm
Data conclude that the up-regulation of sdk-1 (show SDK1 ELISA Kits) in podocytes is an important pathogenic factor in glomerulosclerosis and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 (show CNKSR3 ELISA Kits) function.
Loss of BAP1 (show RNF2 ELISA Kits) expression is associated with lung adenocarcinoma.
Our data confirm the established role of BAP1 as a tumor suppressor protein and is the first report where BAP1 has been studied in pT1 clear cell renal cell carcinomas
Important role of BAP1 (show RNF2 ELISA Kits) in the survival of osteosarcoma cells.
Loss of BAP1 (show RNF2 ELISA Kits) expression is a rare event in non-small cell lung cancer.
BAP1 immunohistochemistry has limited prognostic utility as a complement of CDKN2A (p16) fluorescence in situ hybridization in malignant pleural mesothelioma.
BAP1 (show RNF2 ELISA Kits) and PBRM1 (show PBRM1 ELISA Kits) loss is seen frequently in intrahepatic cholangiocarcinoma
BAP1 (show RNF2 ELISA Kits) loss and high EZH2 (show EZH2 ELISA Kits) expression were highly specific to malignant mesothelioma in differentiating it from benign mesothelial proliferations
We analyzed the prevalence of germline BAP1 (show RNF2 ELISA Kits) mutations in a group of asbestos-exposed malignant mesothelioma patients and found non obviously pathogenic germline sequence variants of BAP1 (show RNF2 ELISA Kits).
NEAT-1 is a downstream effector of gemcitabine sensitivity in CCA (show FBN2 ELISA Kits). The expression of BAP1 (show RNF2 ELISA Kits) is a determinant of sensitivity to therapeutic drugs that can be exploited to enhance responses through combination strategies.
lncFOXO1 suppressed the growth of breast cancer by increasing FOXO1 (show FOXO1 ELISA Kits) transcription. Moreover, we found that lncFOXO1 associated with BRCA-1-associated protein 1 (BAP1 (show RNF2 ELISA Kits)) and regulates its binding and the level of mono-ubiquitinated H2A at K119 (ubH2AK119) at FOXO1 (show FOXO1 ELISA Kits) promoter
The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.
BRCA1-associated protein 1
, ubiquitin C-terminal hydrolase X4
, ubiquitin carboxyl-terminal hydrolase BAP1
, cerebral protein 6
, cerebral protein-13
, Brca1 associated protein 1
, BAI1-associated protein 3
, ubiquitin carboxy-terminal hydrolase
, BAI1-associated protein 1
, guanylate kinase membrane-associated inverted 1
, membrane-associated guanylate kinase inverted 1
, membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1