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anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) Antibodies

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Additionally we are shipping BRISC and BRCA1 A Complex Member 1 Proteins (9) and BRISC and BRCA1 A Complex Member 1 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BABAM1 29086 Q9NWV8
BABAM1 68251 Q3UI43
BABAM1 290631 Q5XIJ6
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Top anti-BRISC and BRCA1 A Complex Member 1 Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-C19orf62 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Formalin-fixed and paraffin-embedded human brain reacted with HSPC142 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of HSPC142 Antibody (Center) (ABIN652514) in MDA-MB231 cell line lysates (35 µg/lane). HSPC142 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Figure 2. Formalin-fixed and paraffin-embedded human brain reacted with HSPC142 Antibody (Center) (Cat#AP18061PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Figure 1. Western blot analysis of HSPC142 Antibody (Center) (Cat#AP18061PU-N) in MDA-MB231 cell line lysates (35ug/lane). HSPC142 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB HSPC142 Antibody (N-term) (ABIN652513) western blot analysis in T47D cell line lysates (15 µg/lane).This demonstrates the HSPC142 antibody detected the HSPC142 protein (arrow). HSPC142 Antibody (N-term) (ABIN652513) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated WB C19ORF62 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit PE IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of C19orf62 expression in transfected 293T cell line by C19orf62 MaxPab polyclonal antibody.Lane 1: HSPC142 transfected lysate(36.19 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to HSPC142 on HeLa cell. [antibody concentration 10 ug/ml] 50 μL Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated FACS, IHC, ELISA, WB 400 μL Log in to see 6 Days
$457.14
Details

BABAM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
, , ,

, , , , ,
Mouse (Murine)


Rat (Rattus)


Top referenced anti-BRISC and BRCA1 A Complex Member 1 Antibodies

  1. Cow (Bovine) Polyclonal BABAM1 Primary Antibody for WB - ABIN2785989 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007 (PubMed)

  2. Human Polyclonal BABAM1 Primary Antibody for EIA, IHC (p) - ABIN453692 : Shao, Patterson-Fortin, Messick, Feng, Shanbhag, Wang, Greenberg: MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. in Genes & development 2009 (PubMed)

More Antibodies against BRISC and BRCA1 A Complex Member 1 Interaction Partners

Human BRISC and BRCA1 A Complex Member 1 (BABAM1) interaction partners

  1. MERIT40 interacts with ABRAXAS which is adaptor molecule of BRCA1-complex.

  2. findings suggest that germline deleterious mutations in C19orf62 should be rare or absent in familial and nonfamilial breast cancer women

  3. NBA1/MERIT40 and BRE (show BRE Antibodies) interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36 (show BRCC3 Antibodies)-containing complexes

  4. Single nucleotide polymorphism in MERIT40 is associated with ovarian cancer.

  5. germline mutations in MERIT40 are rare or absent in familial breast cancer patients.

  6. MERIT40 represents a novel factor that links BRCA1-Rap80 complex integrity, DSB recognition, and ubiquitin chain hydrolytic activities to the DNA damage response.

  7. A stable complex containing MERIT40 acts early in DNA damage response and regulates damage-dependent BRCA1 localization.

  8. NBA1 is required to maintain BRE and Abra1 abundance and for the recruitment of BRCA1 to sites of DNA damage. In depth bioinformatics analysis revealed that the BRCA1 A complex bears striking similarities to the 19S proteasome complex.

Mouse (Murine) BRISC and BRCA1 A Complex Member 1 (BABAM1) interaction partners

  1. Merit40 mutation exacerbated ICL-induced chromosome instability in the context of concomitant Brca2 (show BRCA2 Antibodies) deficiency but not in conjunction with Fancd2 (show FANCD2 Antibodies) mutation.

  2. MERIT40(-/-) hematopoietic stem cells are more resistant to cytoablative stress, and exhibit superior repopulating ability and self-renewal upon serial transplantation.

BRISC and BRCA1 A Complex Member 1 (BABAM1) Antigen Profile

Protein Summary

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component (By similarity).

Gene names and symbols associated with BABAM1

  • BRISC and BRCA1 A complex member 1 (babam1) antibody
  • BRISC and BRCA1 A complex member 1 (BABAM1) antibody
  • BRISC and BRCA1 A complex member 1 (Babam1) antibody
  • 5430437P03Rik antibody
  • C7H19orf62 antibody
  • C19orf62 antibody
  • Merit40 antibody
  • NBA1 antibody
  • zgc:100909 antibody

Protein level used designations for BABAM1

BRCA1-A complex subunit MERIT40 , BRISC and BRCA1-A complex member 1 , mediator of RAP80 interactions and targeting subunit of 40 kDa , new component of the BRCA1-A complex , mediator of Rap80 interactions and targeting 40 kDa , new component of the BRCA1 A complex , new component of the BRCAA1 A complex , Uncharacterized protein C19orf62 homolog

GENE ID SPECIES
445296 Danio rerio
496740 Xenopus (Silurana) tropicalis
29086 Homo sapiens
444814 Xenopus laevis
504517 Bos taurus
68251 Mus musculus
290631 Rattus norvegicus
100173294 Pongo abelii
100395309 Callithrix jacchus
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