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BACH1 encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). Additionally we are shipping BACH1 Proteins (5) and BACH1 Kits (2) and many more products for this protein.
Showing 10 out of 99 products:
Human Monoclonal BACH1 Primary Antibody for WB - ABIN394012
Miyazaki, Kirino, Takeno, Samukawa, Hama, Tanaka, Yamaji, Ueda, Tomita, Fujita, Ishigatsubo: Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1. in Cancer science 2010
Show all 5 references for ABIN394012
Human Polyclonal BACH1 Primary Antibody for EIA, WB - ABIN950595
Hou, Tian, Zheng, Bonkovsky: MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins. in Hepatology (Baltimore, Md.) 2010
Show all 3 references for ABIN950595
Human Polyclonal BACH1 Primary Antibody for IF, ELISA - ABIN1533488
Ohira, Seki, Nagase, Ishikawa, Nomura, Ohara: Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1. in Genomics 1998
Show all 2 references for ABIN1533488
Human Monoclonal BACH1 Primary Antibody for FACS, IHC - ABIN4282846
Cha, Lee, Han, Kim, Kang, Choi, Cho: MicroRNA alteration and putative target genes in high-grade prostatic intraepithelial neoplasia and prostate cancer: STAT3 and ZEB1 are upregulated during prostate carcinogenesis. in The Prostate 2016
Human Polyclonal BACH1 Primary Antibody for WB - ABIN2780352
Litman, Peng, Jin, Zhang, Zhang, Powell, Andreassen, Cantor: BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. in Cancer cell 2005
Bach1 regulates the liver specificity and transience of the Nrf2a (show NFE2L2 Antibodies)-dependent induction of hmox1a and that heme mediates this regulation through Bach1 inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
miR (show MLXIP Antibodies)-196a, which binds to the 3'-untranslated region of the transcriptional repressor BTB and CNC homology 1 (Bach1) and regulates its expression, and subsequently leads to higher levels of lung HO-1 (show HMOX1 Antibodies) mRNA.
Bach1 siRNA exerts protective effects against bleomycin-induced pulmonary fibrosis in mice.
These results suggest that Bach1 and Bach2 (show BACH2 Antibodies) work in a complementary manner to maintain the normal function of the AMs (show MAT1A Antibodies) and surfactant homeostasis in the lung.
By integrating the chromatin immunoprecipitation and next-generation sequencing data with a comparative analysis of gene expression in Bach1-deficient and wild type immortalized mouse embryonic fibroblasts (iMEFs), study found 35 new genes whose expression was repressed by BACH1. Known functions of some of these genes suggested a role of BACH1 in adipocyte differentiation, which was verified using iMEFs.
Bach1 deficiency reduces the severity of osteoarthritis-like changes. This may be due to maintenance of cartilage homeostasis and joint health by antioxidant effects
Bach1 suppresses angiogenesis after ischemic injury and impairs Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling by disrupting the interaction between beta-catenin (show CTNNB1 Antibodies) and TCF4 (show TCF4 Antibodies) and by recruiting histone deacetylase 1 (show HDAC1 Antibodies) to the promoter of TCF4 (show TCF4 Antibodies)-targeted genes.
Bach1 deficiency and accompanying overexpression of HO-1 (show HMOX1 Antibodies) did not influence aging or p53 (show TP53 Antibodies) deficiency-driven tumorigenesis.
Our results suggest that Bach2 (show BACH2 Antibodies) functions with Bach1 and EBF1 (show EBF1 Antibodies) to promote B cell development by repressing myeloid genes in common lymphoid progenitor cells
HO-1 (show HMOX1 Antibodies) induction after ischemia was associated to down-regulation of transcriptional repressor Bach-1, and induction of HO-1 (show HMOX1 Antibodies) when HO enzymatic activity was inhibited was related to worst outcome after brain ischemia.
Bach1 deficiency ameliorates TNBS colitis.
Our results suggest that the bach1-specific small interfering RNA effectively decrease CXCR4 (show CXCR4 Antibodies) receptor, matrix metalloproteinase-9 (show MMP9 Antibodies) expression and breast adenocarcinoma cells invasive, also increased the expression of tumor-suppressive microRNA-203 and miR (show MLXIP Antibodies)-145
BACH1 down-regulation in HT29 colon cancer cells had no effect on cell growth but did inhibit cell migration by decreasing metastasis-related genes expression.
This study indicates that the expression of BACH1 could be elevated as a compensatory mechanism to decrease the globin chain imbalance as well as to reduce the oxidative stress found in hemoglobin E/beta-thalassemia.
A short while ago some studies suggested that BACH1 is involved in cancers, especially breast cancer. This factor is mentioned as a novel master regulator which adjusts several genes involved in bone metastasis of breast cancer, especially CXCR4 (show CXCR4 Antibodies) and MMP1 (show MMP1 Antibodies), two main genes in the enhancement of cancer cell migration and invasion to distant organs. [Review]
Bach1 suppresses cell proliferation and induces cell-cycle arrest and apoptosis.
Induction of GSH-related genes xCT (show SLC7A11 Antibodies) and GCLM (show GCLM Antibodies) were oxygen and Bach1-insensitive during long-term culture under 5% O2, providing the first evidence that genes related to GSH synthesis mediate protection afforded by Nrf2 (show GABPA Antibodies)-Keap1 (show KEAP1 Antibodies) defense pathway
heme oxygenase-1 (show HMOX1 Antibodies) expression is induced by gold nanoparticles through Nrf2 (show GABPA Antibodies) activation and Bach1 export in human vascular endothelial cells
Cyanidin-3-O-glucoside protects HUVECs from palmitic acid-induced injuryby modulating the balance of Nrf2 (show GABPA Antibodies) versus Bach1 inside the nucleus so influencing upregulation of electrophile responsive element mediated gene expression.
sensitizer-induced up-regulation of both the endogenous HMOX1 (show HMOX1 Antibodies) and the luciferase constructs under the control of the HMOX1 (show HMOX1 Antibodies)-ARE or the full HMOX1 (show HMOX1 Antibodies) promoter appear to be under the control of both Nrf2 (show GABPA Antibodies) and Bach1.
This study demonstrated that Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1 (show HMOX1 Antibodies)/BVR-a (show BLVRA Antibodies) system.
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene.
BTB and CNC homology 1 transcription factor
, BTB and CNC homology 1, basic leucine zipper transcription factor 1
, basic leucine zipper transcription factor 1
, transcription regulator protein BACH1-like
, BTB and CNC homolog 1
, transcription regulator protein BACH1
, basic region leucine zipper transcriptional regulator BACH1