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BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 Proteins (BACH2)

Transcriptional regulator that acts as repressor or activator. Additionally we are shipping BACH2 Antibodies (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat BACH2 BACH2 313125  
BACH2 60468 Q9BYV9
BACH2 12014  
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Top BACH2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

BACH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) Interaction Partners

Human BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) interaction partners

  1. The study identifies a strong association of Coeliac Disease with a network of BACH2 regulated genes, supporting emerging evidence of an important role of BACH2 in the regulation of T cell differentiation and prevention of autoimmune disease.

  2. The investigated Bach2 gene polymorphisms (rs11755527, rs3757247, rs12212193 and rs2474619) are not related to the susceptibility to either Vogt-Koyanagi-Harada syndrome and Behcet's disease in our investigated Chinese Han population.

  3. Gene expression analysis revealed that three gene BACH2, PTGER4 (show PTGER4 Proteins) and ZFP36L1 (show ZFP36L1 Proteins), are down-regulated in MS patients' blood cells compared to healthy subjects.

  4. These observations suggested that the unstructured region of Bach2 is important for heme binding, and consequently for its functional regulation

  5. A restored BACH2 expression in BACH2-silenced gastric cancer cell lines, and knockdown of BACH2 using short hairpin RNA (i.e. RNA interference) increased cell proliferation in gastric cancer cells.

  6. The type 1 diabetes candidate gene BACH2 regulates proinflammatory cytokine-induced apoptotic pathways in pancreatic beta-cells by crosstalk with another candidate gene, PTPN2 (show PTPN2 Proteins), and activation of JNK1 (show MAPK8 Proteins) and BIM (show BCL2L11 Proteins).

  7. There were multiple independent HIV integrations in several genes, including MKL2 (show MKL2 Proteins) and BACH2; many of these integrations were in clonally expanded cells.

  8. The dynamics of Bach2 expression in response to DNA damage shows that it is a highly sensitive responder to transcription-blocking DNA lesions.

  9. BACH2 expression level is a promising predictor of prognosis for diffuse large B cell lymphoma.

  10. Our study clearly demonstrated that BACH2 is a susceptibility gene for GD in the Chinese Han population

Mouse (Murine) BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) interaction partners

  1. PI3K-Akt (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) pathway inhibits Bach2 by both repressing its expression and inducing its phosphorylation in B cells.

  2. Bach2 is suggested to cooperate with HDAC3 (show HDAC3 Proteins)-containing co-repressor complexes in B cells to regulate the stage-specific expression of Prdm1 (show PRDM1 Proteins) by writing epigenetic modifications at the Prdm1 (show PRDM1 Proteins) locus.

  3. These findings demonstrate that BACH2 is a key component of the molecular program of tumor immunosuppression and identify therapeutic targets for the reversal of immunosuppression in cancer.

  4. Our results suggest that Bach2 functions with Bach1 (show BACH1 Proteins) and EBF1 (show EBF1 Proteins) to promote B cell development by repressing myeloid genes in common lymphoid progenitor cells

  5. Menin (show MEN1 Proteins) binding at the Bach2 locus and the Bach2 expression are decreased in the senescent CD4 (show CD4 Proteins) T cells.

  6. The dynamics of Bach2 expression in response to DNA damage shows that it is a highly sensitive responder to transcription-blocking DNA lesions.

  7. BCL6 (show BCL6 Proteins) and BACH2 cooperate to orchestrate gene expression patterning in Germinal center B cells through both transcriptional and biochemical mechanisms, which collectively determine the proper initiation and timing of terminal differentiation.

  8. Bach2 enforces T cell quiescence, promotes the development and survival of Treg lineage, restrains aberrant differentiation of Treg cells, and protects against immune-mediated diseases.

  9. Bach2 is required for the functional maturation of alveolar macrophages and pulmonary homeostasis.

  10. Data suggest that repression of the Bach2 transcription factor, which results from antigen experience, contributes to predisposition of IgG1 memory B cells to differentiate into plasma cells.

BACH2 Protein Profile

Protein Summary

Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity).

Gene names and symbols associated with BACH2

  • similar to BTB and CNC homology 1, basic leucine zipper transcription factor 2 (RGD1562865)
  • BTB and CNC homology 1, basic leucine zipper transcription factor 2b (bach2b)
  • BTB and CNC homology 1, basic leucine zipper transcription factor 2 (BACH2)
  • BTB and CNC homology 1, basic leucine zipper transcription factor 2 (LOC100218595)
  • BTB and CNC homology 1, basic leucine zipper transcription factor 2 (LOC100351257)
  • BTB and CNC homology 1, basic leucine zipper transcription factor 2 (bach2)
  • BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2)
  • BTB and CNC homology 2 (Bach2)
  • bach2 protein
  • BTBD25 protein
  • E030004N02Rik protein
  • si:dkeyp-4f12.1 protein
  • si:dkeyp-4f12.2 protein

Protein level used designations for BACH2

transcription regulator protein BACH2 , BTB and CNC homology 2 , BTB and CNC homology 1, basic leucine zipper transcription factor 2 , transcription regulator protein BACH2-like , BTB and CNC homolog 2 , Transcription regulator protein BACH2 (BTB and CNC homolog 2)

GENE ID SPECIES
313125 Rattus norvegicus
555350 Danio rerio
702740 Macaca mulatta
100065814 Equus caballus
100218595 Taeniopygia guttata
100351257 Oryctolagus cuniculus
100402816 Callithrix jacchus
100447938 Pongo abelii
100467178 Ailuropoda melanoleuca
100485849 Xenopus (Silurana) tropicalis
100025933 Monodelphis domestica
100554926 Anolis carolinensis
100595920 Nomascus leucogenys
60468 Homo sapiens
538296 Bos taurus
366340 Rattus norvegicus
481923 Canis lupus familiaris
421809 Gallus gallus
12014 Mus musculus
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