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Transcriptional regulator that acts as repressor or activator. Additionally we are shipping BACH2 Antibodies (68) and many more products for this protein.
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The study identifies a strong association of Coeliac Disease with a network of BACH2 regulated genes, supporting emerging evidence of an important role of BACH2 in the regulation of T cell differentiation and prevention of autoimmune disease.
The investigated Bach2 gene polymorphisms (rs11755527, rs3757247, rs12212193 and rs2474619) are not related to the susceptibility to either Vogt-Koyanagi-Harada syndrome and Behcet's disease in our investigated Chinese Han population.
Gene expression analysis revealed that three gene BACH2, PTGER4 (show PTGER4 Proteins) and ZFP36L1 (show ZFP36L1 Proteins), are down-regulated in MS patients' blood cells compared to healthy subjects.
These observations suggested that the unstructured region of Bach2 is important for heme binding, and consequently for its functional regulation
A restored BACH2 expression in BACH2-silenced gastric cancer cell lines, and knockdown of BACH2 using short hairpin RNA (i.e. RNA interference) increased cell proliferation in gastric cancer cells.
The type 1 diabetes candidate gene BACH2 regulates proinflammatory cytokine-induced apoptotic pathways in pancreatic beta-cells by crosstalk with another candidate gene, PTPN2 (show PTPN2 Proteins), and activation of JNK1 (show MAPK8 Proteins) and BIM (show BCL2L11 Proteins).
There were multiple independent HIV integrations in several genes, including MKL2 (show MKL2 Proteins) and BACH2; many of these integrations were in clonally expanded cells.
The dynamics of Bach2 expression in response to DNA damage shows that it is a highly sensitive responder to transcription-blocking DNA lesions.
BACH2 expression level is a promising predictor of prognosis for diffuse large B cell lymphoma.
Our study clearly demonstrated that BACH2 is a susceptibility gene for GD in the Chinese Han population
PI3K-Akt (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) pathway inhibits Bach2 by both repressing its expression and inducing its phosphorylation in B cells.
Bach2 is suggested to cooperate with HDAC3 (show HDAC3 Proteins)-containing co-repressor complexes in B cells to regulate the stage-specific expression of Prdm1 (show PRDM1 Proteins) by writing epigenetic modifications at the Prdm1 (show PRDM1 Proteins) locus.
These findings demonstrate that BACH2 is a key component of the molecular program of tumor immunosuppression and identify therapeutic targets for the reversal of immunosuppression in cancer.
Our results suggest that Bach2 functions with Bach1 (show BACH1 Proteins) and EBF1 (show EBF1 Proteins) to promote B cell development by repressing myeloid genes in common lymphoid progenitor cells
Menin (show MEN1 Proteins) binding at the Bach2 locus and the Bach2 expression are decreased in the senescent CD4 (show CD4 Proteins) T cells.
BCL6 (show BCL6 Proteins) and BACH2 cooperate to orchestrate gene expression patterning in Germinal center B cells through both transcriptional and biochemical mechanisms, which collectively determine the proper initiation and timing of terminal differentiation.
Bach2 enforces T cell quiescence, promotes the development and survival of Treg lineage, restrains aberrant differentiation of Treg cells, and protects against immune-mediated diseases.
Bach2 is required for the functional maturation of alveolar macrophages and pulmonary homeostasis.
Data suggest that repression of the Bach2 transcription factor, which results from antigen experience, contributes to predisposition of IgG1 memory B cells to differentiate into plasma cells.
Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity).
transcription regulator protein BACH2
, BTB and CNC homology 2
, BTB and CNC homology 1, basic leucine zipper transcription factor 2
, transcription regulator protein BACH2-like
, BTB and CNC homolog 2
, Transcription regulator protein BACH2 (BTB and CNC homolog 2)