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The protein encoded by BTG3 is a member of the BTG/Tob family. Additionally we are shipping BTG3 Kits (10) and BTG3 Proteins (5) and many more products for this protein.
Showing 10 out of 39 products:
Human Polyclonal BTG3 Primary Antibody for EIA, IHC (p) - ABIN950689
Majid, Dar, Ahmad, Hirata, Kawakami, Shahryari, Saini, Tanaka, Dahiya, Khatri, Dahiya: BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. in Carcinogenesis 2009
Show all 5 references for ABIN950689
Human Polyclonal BTG3 Primary Antibody for ICC, IF - ABIN4285522
Deng, Zhao, Gou, Chen, Mao, Takano, Zheng: Decreased expression of BTG3 was linked to carcinogenesis, aggressiveness, and prognosis of ovarian carcinoma. in Tumour biology 2013
Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma.
Results suggest that ANA is a suppressor of ectopic bone formation induced by bone morphogenetic proteins, and this inhibitory ANA activity is a part of the negative feedback regulation of BMP function.
BTG3 overexpression might reverse the aggressive phenotypes and be employed as a potential target for gene therapy of gastric cancer.
The suppressed migration and invasion abilities found in BTG3-overexpressing esophageal adenocarcinoma cells. Our findings suggested that BTG3 is suppressor in the progression of esophageal adenocarcinoma
BTG3 binds and suppresses AKT (show AKT1 Antibodies), a kinase frequently deregulated in cancers.
Down-regulation of BTG3 promotes cell proliferation, migration and invasion in gastric cancer.
BTG3 protein expression may be considered as a good marker to indicate the favorable prognosis of epithelial ovarian carcinoma.
These results disclosed an important role of BTG3 in lung tumorigenesis.
BTG3-dependent CHK1 (show CHEK1 Antibodies) ubiquitination contributes to its chromatin localization and activation and a defect in this regulation may increase genome instability and promote tumorigenesis
loss of BTG3 in normal cells induced cellular senescence, which was correlated with enhanced ERK (show EPHB2 Antibodies)-AP1 (show FOSB Antibodies) signaling and elevated expression of the histone H3K27me3 demethylase (show MBD2 Antibodies) JMJD3/KDM6B (show Kdm6b Antibodies)
by disrupting the DNA binding activity of E2F1 (show E2F1 Antibodies), BTG3 participates in the regulation of E2F1 (show E2F1 Antibodies) target gene expression. Therefore, our studies have revealed a previously unidentified pathway through which the activity of E2F1 (show E2F1 Antibodies) may be guarded by activated p53 (show TP53 Antibodies).
These data support the hypothesis that BTG3 may act to suppress tumorigenesis and that hypermethylation is an important mechanism for inactivation of BTG3 and perhaps other tumor suppressor genes.
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
B cell translocation protein 3
, protein BTG3
, B-cell translocation gene 3
, BTG family member 3
, abundant in neuroepithelium area protein
, protein Tob5