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BIRC6 encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. Additionally we are shipping BIRC6 Antibodies (66) and and many more products for this protein.
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Results show that in addition to the scaffolding function in complex formation, BRUCE has an E3 ligase function to promote BRIT1 (show MCPH1 ELISA Kits) deubiquitination by USP8 (show USP8 ELISA Kits) leading to accumulation of BRIT1 (show MCPH1 ELISA Kits) at DNA double-strand break.
BIRC6 overexpression is a predictor of poor prognosis in colorectal cancer and could be a potential target for colorectal cancer therapy.
The study demonstrates that the T allele of the rs2754511 in the BIRC6 gene plays a protective role in pseudoexfoliative glaucoma patients of the Pakistani population.
Humanin signaling pathway via htHNR/JAKs/STAT3 (show STAT3 ELISA Kits) increased the expression levels of mRNA and protein of Apollon/Bruce, an unusual member of the inhibitors of apoptosis proteins
BRUCE acts as a scaffold, bridging the ubiquitin-specific peptidase 8 (USP8 (show USP8 ELISA Kits)) and BRIT1 (show MCPH1 ELISA Kits) in a complex to coordinate USP8 (show USP8 ELISA Kits)-catalyzed deubiquitination of BRIT1 (show MCPH1 ELISA Kits).
findings demonstrate that BIRC6 overexpression in hepatocellular carcinoma specimens is indicative of poor prognosis and that its interaction with p53 (show TP53 ELISA Kits) facilitates the degradation of p53 (show TP53 ELISA Kits)
The expression of BIRC6 in the cytoplasm is associated with epithelial ovarian cancer (EOC) differentiation and may be a novel predictor for poor prognosis of EOC patients after curative resection.
APPOLON to be a novel regulator of mitotic CYCLIN A (show CCNA2 ELISA Kits) degradation independent of SAC (show ADCY10 ELISA Kits).
Elevated expression of BIRC6 protein in non-small-cell lung cancers is associated with cancer recurrence and chemoresistance.
Knockdown experiments were performed using BIRC6 lentiviral shRNA and phenotype responses were analyzed by Western blot and MTT-assays.Upon silencing of BIRC6 by shRNA, DIABLO protein levels increased and cells went into apoptosis.
The results of this study reveal the importance of BIRC6 expression for embryo survival during bovine preimplantation embryo development.
BRUCE protects cells against apoptosis and functions as an inhibitor of apoptosis.
BRUCE is broadly expressed in embryonic, extraembryonic, and adult mouse tissues, this bifunctional protein might play a unique role in normal trophoblast differentiation and embryonic survival
p53 (show TP53 ELISA Kits) is a downstream effector of Bruce, and, in response to loss of Bruce function, p53 (show TP53 ELISA Kits) activates Pidd (show PIDD ELISA Kits)/caspase-2 (show CASP2 ELISA Kits) and Bax (show BAX ELISA Kits)/Bak (show BAK1 ELISA Kits), leading to mitochondrial apoptosis
Birc6 plays a role in cell division
These results establish a previously unrecognized link between NFAT (show NFATC1 ELISA Kits) signaling and regulation of IAP (show ALPI ELISA Kits) expression and are the first to identify a signaling pathway that increases BRUCE expression.
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.
baculoviral IAP repeat-containing 6 (apollon)
, baculoviral IAP repeat-containing 6
, BIR repeat-containing ubiquitin-conjugating enzyme
, baculoviral IAP repeat-containing protein 6
, ubiquitin-conjugating BIR domain enzyme apollon
, ubiquitin-conjugating BIR-domain enzyme apollon
, baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme
, baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; accccbaculoviral IAP repeat-containing 6