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Basal Cell Adhesion Molecule (Lutheran Blood Group) Proteins (BCAM)

BCAM encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. Additionally we are shipping BCAM Antibodies (41) and BCAM Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BCAM 57278 Q9R069
BCAM 4059 P50895
BCAM 78958 Q9ESS6
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Top BCAM Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Rat His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse Fc Tag 50 μg Log in to see 16 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,474.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

BCAM Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
, ,
Human , , , ,
, , ,
Rat (Rattus) ,

Top referenced BCAM Proteins

  1. Human BCAM Protein expressed in Human Cells - ABIN2002410 : El Nemer, Wautier, Rahuel, Gane, Hermand, Galactéros, Wautier, Cartron, Colin, Le Van Kim: Endothelial Lu/BCAM glycoproteins are novel ligands for red blood cell alpha4beta1 integrin: role in adhesion of sickle red blood cells to endothelial cells. in Blood 2007 (PubMed)
    Show all 4 references for ABIN2002410

  2. Rat (Rattus) BCAM Protein expressed in Human Cells - ABIN2009334 : Campbell, Foulkes, Senger, Trowsdale, Garin-Chesa, Rettig: Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily. in Cancer research 1994 (PubMed)
    Show all 4 references for ABIN2009334

  3. Mouse (Murine) BCAM Protein expressed in Human Cells - ABIN2008453 : Parsons, Mallinson, Holmes, Houlihan, Simpson, Mawby, Spurr, Warne, Barclay, Anstee: The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver. in Proceedings of the National Academy of Sciences of the United States of America 1995 (PubMed)
    Show all 4 references for ABIN2008453

More Proteins for Basal Cell Adhesion Molecule (Lutheran Blood Group) (BCAM) Interaction Partners

Mouse (Murine) Basal Cell Adhesion Molecule (Lutheran Blood Group) (BCAM) interaction partners

  1. Lu/BCAM may have a critical role in facilitating the accumulation of monocytes and macrophages, thereby exacerbating renal injury in crescentic glomerulonephritis.

  2. Lutheran (Lu), also known as basal cell adhesion molecule (B-CAM), competes with integrins for binding to laminin alpha5, a subunit of LM-511, a major component of basement membranes.

  3. Lu/BCAM, as a laminin receptor, is involved in vivo in the maintenance of normal basement membrane organization in the kidney and intestine.

Human Basal Cell Adhesion Molecule (Lutheran Blood Group) (BCAM) interaction partners

  1. Cytometry analysis evidenced a specific expression profile on reticulocytes of SCA infants, with notably an increased expression of the adhesion molecules Lu/BCAM, ICAM-4 (show ICAM4 Proteins) and LFA-3, both in percentage of positive cells and in surface density.

  2. Through molecular genotyping we also identified polymorphisms in RhCE, Kell, Duffy, Colton, Lutheran and Scianna loci in donors and patients.

  3. The variable levels of expression of mutated JAK2 (show JAK2 Proteins) and BCAM (show BCAT2 Proteins) proteins determine different adhesion patterns of erythrocytes from polycythemia vera (show IGF2BP3 Proteins) patients.

  4. These studies revealed amino acids 720 to 1014 of CNF1 as the binding site for Lu/BCAM.

  5. High BCAM (show BCAT2 Proteins) expression is associated with hepatocellular carcinoma.

  6. Adhesion of sickle reticulocytes to HC-treated endothelial cells was decreased despite the HC-derived increase of Lu/BCAM expression.

  7. tumor cell migration on LM-511 requires that Lu/B-CAM competitively modulates cell attachment through integrins.

  8. DARC (show DARC Proteins) and BCAM (show BCAT2 Proteins) expression was associated with pathogenesis of thyroid carcinoma and correlated with clinical-pathological features.

  9. Glu425 in the Lu glycoprotein is required for expression of Lu7, and Ala425 is associated with the LU:-7 phenotype. This completes the molecular basis associated with all antigens known to be in the Lutheran blood group system.

  10. Increases in adhesion frequency provide significant evidence of the role of epinephrine in BCAM/Lu-laminin and ICAM-4 (show ICAM4 Proteins)-alpha(v)beta(3) bonding, and suggest mechanisms of vaso-occlusion during physical exertion in sickle cell trait.

BCAM Protein Profile

Protein Summary

This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with BCAM

  • basal cell adhesion molecule (Lutheran blood group) (bcam)
  • basal cell adhesion molecule (Lutheran blood group) (BCAM)
  • basal cell adhesion molecule (Bcam)
  • basal cell adhesion molecule (Lutheran blood group) (Bcam)
  • 1200005K12Rik protein
  • AU protein
  • B-CAM protein
  • CD239 protein
  • Gplu protein
  • Lu protein
  • MGC81012 protein
  • MSK19 protein
  • prr2 protein
  • zgc:154034 protein

Protein level used designations for BCAM

basal cell adhesion molecule (Lutheran blood group) , Auberger b antigen , Lutheran blood group , basal cell adhesion molecule (Lu and Au blood groups) , basal cell adhesion molecule , LU , basal cell adhesion molecule-like , B-CAM cell surface glycoprotein , lutheran antigen , lutheran glycoprotein , B-cell adhesion molecule , F8/G253 antigen , antigen identified by monoclonal antibody F8 , glycoprotein 95kDa , Lutheran blood group (Auberger b antigen included)

GENE ID SPECIES
100036718 Xenopus (Silurana) tropicalis
444320 Xenopus laevis
484456 Canis lupus familiaris
714568 Macaca mulatta
744276 Pan troglodytes
767689 Danio rerio
100070622 Equus caballus
100446557 Pongo abelii
100477918 Ailuropoda melanoleuca
57278 Mus musculus
4059 Homo sapiens
78958 Rattus norvegicus
282862 Bos taurus
Selected quality suppliers for BCAM Proteins (BCAM)
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