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BTF3 encodes the basic transcription factor 3. Additionally we are shipping BTF3 Antibodies (74) and BTF3 Kits (2) and many more products for this protein.
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BTF3, HINT1 (show HINT1 Proteins), NDRG1 (show NDRG1 Proteins) and ODC1 (show ODC1 Proteins) protein over-expression in human prostate cancer tissue
BTF3 expression is associated with enhanced cell proliferation, reduced cell cycle regulation and apoptosis and its silencing decreased colony forming and proliferation of gastric cancer cells.
BTF3 overexpression may be an early event in colorectal cancer development and could be useful biomarker for the early stage of colorectal cancers (CRC (show CALR Proteins)); BTF3 has positive correlations with NF-kappaB (show NFKB1 Proteins), RAD50 (show RAD50 Proteins), MRE11 (show MRE11A Proteins), NBS1 (show NBN Proteins) and AEG-1 (show MTDH Proteins) and might influence complex signal pathways in CRC (show CALR Proteins)
BTF3 is overexpressed in pancreatic ductal adenocarcinoma , where it acts as a transcriptional regulator rather than a direct modulator of apoptosis.
BTF3 interacts with ERalpha (show ESR1 Proteins) that has been activated either by 17beta-estradiol (ligand-dependent activation) or by epidermal growth factor (show EGF Proteins) (ligand-independent activation).
In addition to RNA polymerase II (otherwise RNA pol II, RNA polymerase B), four general transcription factors are required for initiation of transcription: BTF1 (show BTN2A1 Proteins) (also referred to as TFIID (show TBP Proteins)) which has recently been cloned from yeast, BTF2 (show GTF2H1 Proteins), BTF3 and STF.
Six putative caspase (show CASP3 Proteins) substrates, including five novel proteins (ABCF1 (show ABCF1 Proteins), AKAP1 (show AKAP1 Proteins), CPE (show CPE Proteins), DOPEY1 and GOPC1 (show GOPC Proteins)) that may be targeted specifically by the initiator caspases 8 and 10 during the early stages of apoptosis, were identified.[caspase 10 (show CASP10 Proteins)]
This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes.
basic transcription factor 3
, transcription factor BTF3
, RNA polymerase B transcription factor 3
, nascent-polypeptide-associated complex beta polypeptide