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Beaded Filament Structural Protein 1, Filensin Proteins (BFSP1)

More than 99% of the vertebrate ocular lens is comprised of terminally differentiated lens fiber cells. Additionally we are shipping Filensin Antibodies (62) and Filensin Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BFSP1 631 Q12934
BFSP1 25394 Q02435
BFSP1 12075 A2AMT1
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Top Filensin Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,782.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

BFSP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for Beaded Filament Structural Protein 1, Filensin (BFSP1) Interaction Partners

Human Beaded Filament Structural Protein 1, Filensin (BFSP1) interaction partners

  1. A novel mutation (c.1042G>A) at exon 7 of BFSP1, which creates a substitution of an aspartate to an asparagine (p.D348N) was identified to be associated with autosomal dominant congenital cataract in a Chinese family.

  2. The crystallin beta cluster on chromosome 22, GJA3 (show GJA3 Proteins), and BFSP1 play a major role in maintaining lens transparency.

  3. This is the first report of a mutation in the BFSP1 gene associated with human inherited cataracts.

Mouse (Murine) Beaded Filament Structural Protein 1, Filensin (BFSP1) interaction partners

  1. disruption of the Hsf4 (show HSF4 Proteins) gene leads to cataracts via at least three pathways: down-regulation of gamma-crystallin, particularly gamma S-crystallin (show CRYGS Proteins); decreased lens beaded filament expression; and loss of post-translational modification of alpha A-crystallin (show CRYAA Proteins)

Filensin (BFSP1) Protein Profile

Protein Summary

More than 99% of the vertebrate ocular lens is comprised of terminally differentiated lens fiber cells. Two lens-specific intermediate filament-like proteins, CP49 (also known as phakinin) and the protein product of this gene, filensin, are expressed only after fiber cell differentiation has begun. Both proteins are found in a structurally unique cytoskeletal element that is referred to as the beaded filament (BF). Mutations in this gene are the cause of autosomal recessive cortical juvenile-onset cataract. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with BFSP1

  • beaded filament structural protein 1, filensin (BFSP1)
  • filensin (Bfsp1)
  • beaded filament structural protein 1, filensin (bfsp1)
  • beaded filament structural protein 1, filensin (LOC100218632)
  • beaded filament structural protein 1, filensin (LOC100220461)
  • beaded filament structural protein 1, filensin (Bfsp1)
  • beaded filament structural protein 1, in lens-CP94 (Bfsp1)
  • filensin-like (LOC100521759)
  • 115-kDa protein
  • Bfsp1 protein
  • CP94 protein
  • CP95 protein
  • CP97 protein
  • CP115 protein
  • CTRCT33 protein
  • LIFL-H protein
  • LOC100218632 protein
  • LOC100220461 protein
  • MGC84254 protein

Protein level used designations for BFSP1

beaded filament structural protein 1, filensin , filensin , filensin-like , cytoskeletal protein, 115 KD , lens fiber cell beaded-filament structural protein CP 115 , lens intermediate filament-like heavy , CP97 115-kDa , lens fiber cell beaded-filament structural protein CP 94 , CP95 , lens fiber cell beaded-filament structural protein CP 95 , beaded filament structural protein in lens-CP94

GENE ID SPECIES
695840 Macaca mulatta
458107 Pan troglodytes
100170758 Cavia porcellus
444665 Xenopus laevis
100062535 Equus caballus
100218632 Taeniopygia guttata
100220461 Taeniopygia guttata
100347138 Oryctolagus cuniculus
100392909 Callithrix jacchus
100447671 Pongo abelii
100607956 Nomascus leucogenys
281644 Bos taurus
631 Homo sapiens
101121536 Ovis aries
485756 Canis lupus familiaris
25394 Rattus norvegicus
396056 Gallus gallus
12075 Mus musculus
100521759 Sus scrofa
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