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Beclin 1, Autophagy Related Proteins (BECN1)

Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010].. Additionally we are shipping Beclin 1 Antibodies (448) and Beclin 1 Kits (40) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BECN1 8678 Q14457
BECN1 56208 O88597
BECN1 114558 Q91XJ1
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Top Beclin 1 Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 20 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$785.40
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$3,246.83
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,246.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,256.00
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$3,256.00
Details

BECN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Top referenced Beclin 1 Proteins

  1. Human Beclin 1 Protein expressed in Wheat germ - ABIN1346622 : Giatromanolaki, Koukourakis, Koutsopoulos, Chloropoulou, Liberis, Sivridis: High Beclin 1 expression defines a poor prognosis in endometrial adenocarcinomas. in Gynecologic oncology 2011 (PubMed)
    Show all 3 references for ABIN1346622

  2. Human Beclin 1 Protein expressed in Escherichia coli (E. coli) - ABIN1098220 : Itakura, Kishi, Inoue, Mizushima: Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. in Molecular biology of the cell 2008 (PubMed)
    Show all 2 references for ABIN1098220

More Proteins for Beclin 1, Autophagy Related (BECN1) Interaction Partners

Zebrafish Beclin 1, Autophagy Related (BECN1) interaction partners

  1. Beclin1 plays an important role in vincristine-induced dopaminergic neurons toxicity.

Human Beclin 1, Autophagy Related (BECN1) interaction partners

  1. Nuclear Beclin1 overexpression is associated with colorectal cancer.

  2. Beclin-1 acts as a tumor suppressor by regulating the hedgehog (HH) signaling pathway through Gli2 expression in gastric adenocarcinoma.

  3. Results show that the expression of AMBRA1 (show AMBRA1 Proteins) and Beclin-1 is increased in human gastric adenocarcinoma (GC) tissues. High protein expression of AMBRA1 (show AMBRA1 Proteins) and Beclin-1 is correlated with tumor invasion and is an independent poor prognostic marker in GC patients.

  4. These results demonstrate that Beclin1 acts as a tumour suppressor in the development or progression of OTSCC and that Beclin1 may represent a novel prognostic marker for patients with OTSCC.

  5. the overexpression of Beclin 1 promoted apoptosis and decreased invasion by upregulating the expression of ECRG4 (show C2orf40 Proteins) in A549 lung adenocarcinoma cells. Therefore, the selection of Beclin l as a target for gene therapy represents a more effective method for the treatment of lung cancer.

  6. PVT1 overexpression increased the expression of Atg7 (show ATG7 Proteins) and Beclin1 by targeting miR (show MLXIP Proteins)-186, which induced protective autophagy, thus promoting glioma vascular endothelial cell proliferation, migration, and angiogenesis. Therefore, PVT1 and miR (show MLXIP Proteins)-186 can provide new therapeutic targets for future anti-angiogenic treatment of glioma

  7. our study further confirms that Beclin1- and reactive oxygen species-dependent autophagy induced by ABT-737 also plays a protective function in HepG2/ADM (show ADM Proteins) cells, which show B-cell lymphoma 2 expression higher than that in HepG2 cells.

  8. miR-17-5p plays an important role in radiosensitivity of glioma cells by inhibiting beclin-1-mediated autophagy. Targeting miR-17-5p/beclin-1/autophagy pathway may be a promising strategy to enhance the efficacy of radiotherapy in glioma.

  9. Low expression of BECN1 is associated with lymph node metastasis in gastric cancer.

  10. High Beclin-1 expression (alone or in combination with SIRT1 (show SIRT1 Proteins)) predicted shorter overall survival and relapse-free survival in gastric cancer.

Mouse (Murine) Beclin 1, Autophagy Related (BECN1) interaction partners

  1. this study shows that knockdown of beclin1 enhances macrophage-associated (show CD163 Proteins) phagocytosis and intracellular killing of Pseudomonas aeruginosa

  2. provide the novel evidence that GADD45A (show GADD45A Proteins) inhibits autophagy via impairing the BECN1-PIK3C3 (show PIK3C3 Proteins) complex formation

  3. in-vitro genetic depletion of beclin-1 in high glucose treated adult rat cardiomyocytes markedly inhibited the level of autophagy and subsequent apoptotic cell death.

  4. suggest that neuronal death induced by decreased beclin 1 levels may also be due to impaired trophic factor signaling

  5. FBG1 (show FBXO2 Proteins) degrades A1AT (show SERPINA1 Proteins)-Z through a Beclin1-dependent arm of autophagy.

  6. Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG (show UVRAG Proteins)-VPS34 (show PIK3C3 Proteins) complex.

  7. a mechanism of inverse coregulation between BECN1 and MCL1 (show MCL1 Proteins) significantly contributes to their opposing roles in tumorigenesis

  8. FKBP5 (show FKBP5 Proteins) associates with BECN1, changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux

  9. identifies a novel negative regulator of autophagy and suggests that RNF216 may be a target for treatment of inflammatory diseases

  10. Inverse co-regulation of Beclin 1 and Mcl-1 (show MCL1 Proteins) represents a mechanism of functional counteraction in cancer.

Pig (Porcine) Beclin 1, Autophagy Related (BECN1) interaction partners

  1. Data indicate that the expression of MAP1LC3A (show MAP1LC3A Proteins), B and autophagy-associated genes (ATG5 (show ATG5 Proteins), mTOR (show FRAP1 Proteins), Beclin-1) was increased in normal pigs, while decreased in miniature pigs.

Beclin 1 (BECN1) Protein Profile

Protein Summary

Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009

Gene names and symbols associated with BECN1

  • beclin 1, autophagy related (BECN1)
  • beclin 1, autophagy related (becn1)
  • beclin 1 (atg6)
  • beclin 1 protein (atg6)
  • beclin-1 (CpipJ_CPIJ011087)
  • beclin-1 (PTRG_07825)
  • beclin-1 (SJAG_01876)
  • Beclin-1 (becn1)
  • beclin 1 (coiled-coil, myosin-like BCL2 interacting protein) (becn1)
  • beclin 1, autophagy related (Becn1)
  • beclin-1-like (LOC100352353)
  • 4921513J16Rik protein
  • 5430417M23Rik protein
  • Atg6 protein
  • Beclin-1 protein
  • beclin1 protein
  • becn1 protein
  • VPS30 protein
  • zgc:73097 protein

Protein level used designations for BECN1

beclin 1 (coiled-coil, myosin-like BCL2 interacting protein) , beclin-1 , beclin 1 , GRMZM2G092112 , beclin 1 proteinBeclin-1-like protein , Beclin-1 , myosin-like BCL2 interacting protein , ATG6 autophagy related 6 homolog , beclin 1 (coiled-coil, moesin-like BCL2 interacting protein) , beclin 1 (coiled-coil, moesin-like BCL2-interacting protein) , coiled-coil myosin-like BCL2-interacting protein , Bcl-2-interacting protein beclin , coiled-coil, myosin-like BCL2-interacting protein , beclin 1 (coiled-coil, myosin-like BCL2-interacting protein) , autophagy-related protein 6

GENE ID SPECIES
454700 Pan troglodytes
619357 Xenopus (Silurana) tropicalis
653027 Takifugu rubripes
711649 Macaca mulatta
732797 Zea mays
6043853 Culex quinquefasciatus
6346099 Pyrenophora tritici-repentis Pt-1C-BFP
7048057 Schizosaccharomyces japonicus yFS275
100049387 Oryzias latipes
100136134 Oncorhynchus mykiss
100173145 Pongo abelii
100194789 Salmo salar
393846 Danio rerio
8678 Homo sapiens
56208 Mus musculus
444178 Xenopus laevis
420018 Gallus gallus
733576 Sus scrofa
527278 Bos taurus
114558 Rattus norvegicus
480513 Canis lupus familiaris
100721231 Cavia porcellus
100913170 Ovis aries
100352353 Oryctolagus cuniculus
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