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Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit (By similarity). Additionally we are shipping Block of Proliferation 1 Antibodies (23) and Block of Proliferation 1 Kits (3) and many more products for this protein.
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The DDX27 (show DDX27 Proteins) can interact specifically with the Pes1 (show PES1 Proteins) and Bop1 but fulfils critical function(s) for proper 3' end formation of 47S rRNA independently of the PeBoW-complex.
Block of proliferation 1 (BOP1) plays an oncogenic role in hepatocellular carcinoma by promoting epithelial-to-mesenchymal transition.
Deregulation of the BOP1 pathway contributes to chromosomal instability in colorectal tumorigenesis.
Murine fibroblasts expressing Scx mRNA from an exogenous Scx mini-gene indicated that the accumulation of Bop1 intronic RNA impairs the Scx gene expression in a trans-acting manner, which resulted in the reduction of the Scx mRNA level.
Bop1 form a stable complex with a novel member, WDR12 (show WDR12 Proteins) (PeBoW complex).
Results describe the role of PeBoW-specific proteins Pes1 (show PES1 Proteins), Bop1, and WDR12 (show WDR12 Proteins) in complex assembly and stability, nucleolar transport, and pre-ribosome association.
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit (By similarity).
Block of proliferation 1
, block of proliferation 1
, Block of proliferation 1 protein B
, ribosome biogenesis protein bop1-B
, block of proliferation 1 protein
, ribosome biogenesis protein BOP1
, ribosome biogenesis protein bop1