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Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Additionally we are shipping BRE Proteins (11) and many more products for this protein.
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Human Polyclonal BRE Primary Antibody for WB - ABIN2801968
Li, Yoo, Becker, Ali-Osman, Chan: Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. in Biochemical and biophysical research communications 1995
Show all 4 references for ABIN2801968
Human Polyclonal BRE Primary Antibody for IHC, ELISA - ABIN1001939
Dong, Hakimi, Chen, Kumaraswamy, Cooch, Godwin, Shiekhattar: Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. in Molecular cell 2003
Show all 3 references for ABIN1001939
High BRE and high EVI1 (show MECOM Antibodies) expression are mutually exclusive in MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies)-positive acute myeloid leukemia (show BCL11A Antibodies) patients.
High BRE expression defines a novel subtype of adult acute myeloid leukemia (show BCL11A Antibodies) characterized by a favorable prognosis.
NBA1/MERIT40 (show BABAM1 Antibodies) and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36 (show BRCC3 Antibodies)-containing complexes
overexpression of the BRE gene is predominantly found in MLL (show MLL Antibodies)-rearranged AML (show RUNX1 Antibodies) with t(9;11)(p22 (show DYNC1H1 Antibodies);q23).
A novel stress-responsive gene called BRE which interacts with TNF (show TNF Antibodies)-receptor-1 and blocks the apoptotic effect of TNF-alpha (show TNF Antibodies), was identified.
These results show that BRE over-expression can indeed promote growth, though not initiation, of liver tumors.
BRE mediates antiapoptosis by inhibiting the mitochondrial apoptotic machinery
the enhanced tumor growth is more likely due to the antiapoptotic activity of BRE than any direct effect of the protein on cell proliferation
Antiapoptotic in vivo; Bre levels are regulated post-transcriptionally in the liver, which is not observed in human hepatocellular carcinoma (HCC (show FAM126A Antibodies)) and non-HCC (show FAM126A Antibodies) cell lines.
results implied that BRE plays a significant role in mediating antiapoptotic and proliferative responses in esophageal carcinoma cells
results demonstrate a role for BRE in both replicative senescence and DNA damage-induced premature senescence. This can be attributed to BRE being required for BRCA1-A complex-driven HR DNA repair
Depletion of BRE also increased tumor cell apoptosis, and decreased both local and metastatic tumor growth.
BRE has a role in the regulation of key proteins of the cellular stress-response machinery, including prohibitin (show PHB Antibodies) and p53 (show TP53 Antibodies)
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin (By similarity).
BRCA1-A complex subunit BRE
, BRCA1/BRCA2-containing complex subunit 45
, Brain and reproductive organ-expressed protein
, brain and reproductive organ-expressed (TNFRSF1A modulator)
, BRCA1-A complex subunit BRE-like
, BRCA1/BRCA2-containing complex, subunit 4
, brain and reproductive organ-expressed protein