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Brevican Proteins (BCAN)

BCAN encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. Additionally we are shipping Brevican Antibodies (82) and Brevican Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BCAN 12032 Q61361
Rat BCAN BCAN 25393 P55068
BCAN 63827 Q96GW7
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Top Brevican Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cat His tag   1 mg Log in to see 56 to 66 Days
$3,091.00
Details

BCAN Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Brevican (BCAN) Interaction Partners

Mouse (Murine) Brevican (BCAN) interaction partners

  1. The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held

  2. This study provided evidence that the brevican modulates synaptogenesis and long-term synapse stability. The mutant neurons display reduced frequencies of mEPSCs and mIPSCs.

  3. these results imply that Bral2 (show HAPLN4 Proteins)-brevican interaction may play a key role in synaptic stabilization and the structural integrity of brain perineuronal nets

  4. defective brevican processing observed in amyloid beta-bearing mice may contribute to deficient neural plasticity

  5. Results indicate that reactive gliosis differs between the spinal cord dorsal root entry zone and dorsal column and that Brevican and Versican (show Vcan Proteins) may participate in the inhibitory properties of the dorsal root entry zone.

  6. Brevican is not essential for learning and memory, but plays a role in long-term potentiation in mice

  7. Brevican and the ADAMTS (show ADAMTS1 Proteins)-cleaved fragment of brevican were most broadly distributed in neuropil in the brain.

  8. The proteoglycan (show Vcan Proteins) brevican binds to fibronectin (show FN1 Proteins) after proteolytic cleavage and promotes glioma cell motility

  9. This study show that brevican plays a crucial role in determining the specialization of the hyaluronan-binding nodal matrix assemblies in large diameter nodes.

Human Brevican (BCAN) interaction partners

  1. Data indicate that median methylation levels of BCAN, HOXD1 (show HOXD1 Proteins), KCTD8 (show KCTD8 Proteins), KLF11 (show KLF11 Proteins), NXPH1 (show NXPH1 Proteins), POU4F1 (show POU4F1 Proteins), SIM1 (show SIM1 Proteins), and TCF7L1 (show TCF3 Proteins) were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.

  2. High Brevican is associated with the invasive phenotype of low-grade astrocytoma.

  3. Authors describe the expression of BEHAB/brevican in human brain and characterize two novel glioma-specific isoforms which are generated by differential glycosylation and are absent from normal adult brain and other neuropathologies.

  4. These results demonstrate for the first time that ADAMTS-5 (show ADAMTS5 Proteins) is capable of degrading brevican and is overexpressed in glioblastoma cells, and suggest that ADAMTS-5 (show ADAMTS5 Proteins) may play a role in glioma cell invasion through the cleavage of brevican.

  5. The proteoglycan (show Vcan Proteins) brevican binds to fibronectin (show FN1 Proteins) after proteolytic cleavage and promotes glioma cell motility

Brevican (BCAN) Protein Profile

Protein Summary

This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with Brevican Proteins (BCAN)

  • brevican (bcan)
  • brevican (BCAN)
  • brain enriched hyaluronan binding protein (BEHAB)
  • brevican (Bcan)
  • ALPBRE protein
  • BCAN protein
  • BEHAB protein
  • CSPG7 protein
  • fi32a12 protein
  • wu:fi32a12 protein
  • Xbcan protein

Protein level used designations for Brevican Proteins (BCAN)

brevican core protein , brevican , brevican core protein-like , brevican soluble core protein , Brevican core protein , brain-enriched hyaluronan-binding protein , BEHAB , brevican (brain specific proteoglycan in the aggrecan family) , chondroitin sulfate proteoglycan 7 , chondroitin sulfate proteoglycan BEHAB , chondroitin sulfate proteoglycan BEHAB/brevican

GENE ID SPECIES
334113 Danio rerio
457401 Pan troglodytes
100064356 Equus caballus
100456431 Pongo abelii
398229 Xenopus laevis
100582450 Nomascus leucogenys
727695 Felis catus
12032 Mus musculus
25393 Rattus norvegicus
63827 Homo sapiens
281019 Bos taurus
100339573 Oryctolagus cuniculus
100714598 Cavia porcellus
612102 Canis lupus familiaris
425976 Gallus gallus
101105963 Ovis aries
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