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Bridging Integrator 1 (BIN1) ELISA Kits

BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Additionally we are shipping BIN1 Antibodies (105) and BIN1 Proteins (15) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
BIN1 274 O00499
BIN1 30948 O08539
BIN1 117028 O08839
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Top BIN1 ELISA Kits at antibodies-online.com

Showing 3 out of 10 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.061 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 13 to 16 Days
$589.47
Details
Rat
  96 Tests Log in to see 15 to 18 Days
$1,029.60
Details
Mouse
  96 Tests Log in to see 15 to 18 Days
$1,029.60
Details

More ELISA Kits for BIN1 Interaction Partners

Human Bridging Integrator 1 (BIN1) interaction partners

  1. the depletion of BIN1 increases cellular BACE1 (show BACE ELISA Kits) levels through impaired endosomal trafficking and reduces BACE1 (show BACE ELISA Kits) lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 (show BACE ELISA Kits) levels and Ab production

  2. BIN1 protein expression in cerebral cortex was related to disease progression in Alzheimer's Disease patients.

  3. data show that the previously described consensus sequence PXRPXR for amphiphysin SH3 ligands is inaccurate and instead define it as an extended Class II binding motif PXXPXRpXR, where additional positive charges between the two constant arginine residues can give rise to extraordinary high SH3 binding affinity.

  4. findings support a contribution of BIN1 to individual differences in episodic memory performance among Type 2 Diabetes patients.

  5. analysis of a novel deregulated mechanism in chronic myeloid leukemia (show BCL11A ELISA Kits) patients, indicating BIN1 and RIN1 (show RIN1 ELISA Kits) as players in the maintenance of the abnormal RTK signaling in this hematological disease

  6. BIN1 is involved with late onset Alzheimer's disease. [review]

  7. This study supported that BIN1 contributes to the risk of Alzheimer's disease by altering neural degeneration (abnormal tau, brain atrophy and glucose metabolism) but not Abeta (show APP ELISA Kits) pathology

  8. Alterations in the BIN1 locus, previously associated with Alzheimer disease, may modify the age of onset of GBA (show GBA ELISA Kits)-associated Parkinson.

  9. Data demonstrate that EHBP1L1 links Rab8 (show RAB8A ELISA Kits) and the Bin1-dynamin (show DNM1 ELISA Kits) complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.

  10. In vitro studies in human Caco-2 cells showed that Bin1 antibody altered the expression of tight junction proteins and improved barrier function.

Mouse (Murine) Bridging Integrator 1 (BIN1) interaction partners

  1. the depletion of BIN1 increases cellular BACE1 (show BACE ELISA Kits) levels through impaired endosomal trafficking and reduces BACE1 (show BACE ELISA Kits) lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 (show BACE ELISA Kits) levels and Ab production

  2. Data demonstrate that EHBP1L1 links Rab8 (show RAB8A ELISA Kits) and the Bin1-dynamin (show DNM1 ELISA Kits) complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.

  3. Findings show how cardiac deficiency in Bin1 function causes age- and stress-associated heart failure suggesting that Bin1 is a positive modifier of cardiac contractility that helps sustain adult heart function under stress conditions.

  4. Reorganization of BIN1-induced microdomains recruits phosphorylated ryanodine receptors into dyads, increasing calcium signaling.

  5. Bin1 mAb reduced colitis morbidity in mice while unprotected mice were characterized by severe lesions throughout the mucosa, rupture of lymphoid follicle, high-level neutrophil and lymphocyte infiltration into the mucosal areas, loss of surface crypts.

  6. The release of BIN1 from hypo-poly(ADP-ribosyl)ated E2F1 (show E2F1 ELISA Kits) is a mechanism by which serum starvation promotes E2F1 (show E2F1 ELISA Kits)-induced apoptosis.

  7. BIN1 interacts with MTM1 (show MTM1 ELISA Kits) in skeletal muscle.

  8. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.

  9. Bin1 is a genetic modifier of colitis that controls the paracellular pathway of transcellular ion transport regulated by cellular tight junctions.

  10. Data have identified that membrane-associated BIN1 not only induces membrane curvature but can direct specific antegrade delivery of microtubule-transported membrane proteins.

BIN1 Antigen Profile

Antigen Summary

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Gene names and symbols associated with Bridging Integrator 1 (BIN1) ELISA Kits

  • bridging integrator 1 (BIN1) antibody
  • bridging integrator 1 (bin1) antibody
  • bridging integrator 1 (Bin1) antibody
  • ALP-1 antibody
  • AMPH2 antibody
  • Amphl antibody
  • BIN1 antibody
  • BRAMP-2 antibody
  • cb57 antibody
  • MGC53185 antibody
  • MGC76187 antibody
  • SH3P9 antibody
  • zgc:86701 antibody

Protein level used designations for Bridging Integrator 1 (BIN1) ELISA Kits

bridging integrator 1 , myc box-dependent-interacting protein 1-like , amphiphysin II , amphiphysin-like protein , box dependant MYC interacting protein 1 , box-dependent myc-interacting protein 1 , myc box-dependent-interacting protein 1 , SH3 domain-containing protein 9 , amphiphysin 2 , myc box dependent interacting protein 1 , Amph2 , amphiphysin IIamph2

GENE ID SPECIES
100052213 Equus caballus
380484 Xenopus laevis
394839 Xenopus (Silurana) tropicalis
447863 Danio rerio
735972 Pan troglodytes
100451162 Pongo abelii
100475668 Ailuropoda melanoleuca
100018912 Monodelphis domestica
100544136 Meleagris gallopavo
100599872 Nomascus leucogenys
274 Homo sapiens
30948 Mus musculus
424228 Gallus gallus
100037305 Sus scrofa
117028 Rattus norvegicus
483870 Canis lupus familiaris
614576 Bos taurus
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