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BPTF was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Additionally we are shipping and many more products for this protein.
Showing 10 out of 31 products:
Human Monoclonal BPTF Primary Antibody for ELISA, WB - ABIN968990
Landry, Sharov, Piao, Sharova, Xiao, Southon, Matta, Tessarollo, Zhang, Ko, Kuehn, Yamaguchi, Wu: Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. in PLoS genetics 2008
Show all 2 references for ABIN968990
We find that the melanocyte stem cells from these animals are abnormal and that once they are stimulated at anagen, Bptf is required to ensure the expression of melanocyte markers and their differentiation into mature adult melanocytes.
NURF regulation occurs partly through physical and functional interactions with the ubiquitous and multivalent factors Ctcf and cohesin
Results suggest that BPTF/FAC1 is essential in the extraembryonic lineage for correct development of the ectoplacental cone and fetomaternal interactions.
study concludes that Bptf likely regulates genes and signaling pathways essential for the development of key tissues of the early mouse embryo
somatic frameshift mutations of BPTF were present in gastric cancer and colorectal cancers
BPTF plays an essential role in cell growth and survival by targeting multiply signaling pathways in human lung cancers
High BPTF expression was significantly correlated with tumor progression and may be a potent prognostic marker of colorectal cancer.
The PHD (show PDC Antibodies)-adjacent bromodomain in BPTF binds with marked selectivity H4K16ac, in combination with H3K4me3 at the mononucleosome level.
the novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype
hkelch-like ECH (show NFE2L2 Antibodies)-associated protein 1 regulates FAC1 in addition to its known role in control of Nrf2 (show GABPA Antibodies)
These findings suggest a role for FAC1 in apoptosis following release of Nrf2 (show GABPA Antibodies) from Keap1 (show KEAP1 Antibodies) in response to oxidative stress.
crystallographic and NMR structures of the bromodomain-proximal PHD (show PDC Antibodies) finger of BPTF in free and H3(1-15)K4me3-bound states
High FALZ expression is associated with metastatic spread to the brain in primary non-small cell lung cancer.
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely.
fetal Alzheimer antigen
, nucleosome-remodeling factor subunit BPTF
, bromodomain PHD finger transcription factor
, nucleosome-remodeling factor subunit BPTF-like
, fetal alzheimer antigen, falz
, bromodomain and PHD domain transcription factor
, bromodomain and PHD finger-containing transcription factor
, fetal Alz-50 clone 1 protein
, fetal Alz-50 reactive clone 1
, nucleosome remodeling factor, large subunit