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CLEC10A encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Additionally we are shipping CLEC10A Proteins (21) and CLEC10A Kits (1) and many more products for this protein.
Showing 10 out of 137 products:
Mouse (Murine) Monoclonal CLEC10A Primary Antibody for FACS - ABIN2658176
Sakakura, Oo-Puthinan, Moriyama, Kimura, Moriya, Irimura, Shimada: Carbohydrate binding mechanism of the macrophage galactose-type C-type lectin 1 revealed by saturation transfer experiments. in The Journal of biological chemistry 2008
Show all 7 references for ABIN2658176
Mouse (Murine) Monoclonal CLEC10A Primary Antibody for IF - ABIN2657165
Singh, Streng-Ouwehand, Litjens, Weelij, García-Vallejo, van Vliet, Saeland, van Kooyk: Characterization of murine MGL1 and MGL2 C-type lectins: distinct glycan specificities and tumor binding properties. in Molecular immunology 2009
Show all 7 references for ABIN2657165
Mouse (Murine) Monoclonal CLEC10A Primary Antibody for FACS - ABIN2662591
Tsuiji, Fujimori, Ohashi, Higashi, Onami, Hedrick, Irimura: Molecular cloning and characterization of a novel mouse macrophage C-type lectin, mMGL2, which has a distinct carbohydrate specificity from mMGL1. in The Journal of biological chemistry 2002
Show all 7 references for ABIN2662591
Mouse (Murine) Monoclonal CLEC10A Primary Antibody for FACS - ABIN2659221
Denda-Nagai, Aida, Saba, Suzuki, Moriyama, Oo-Puthinan, Tsuiji, Morikawa, Kumamoto, Sugiura, Kudo, Akimoto, Kawakami, Bovin, Irimura: Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells. in The Journal of biological chemistry 2010
Show all 7 references for ABIN2659221
Mouse (Murine) Monoclonal CLEC10A Primary Antibody for ICFC - ABIN2660073
Westcott, Delproposto, Geletka, Wang, Singer, Saltiel, Lumeng: MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. in The Journal of experimental medicine 2009
Show all 7 references for ABIN2660073
Mouse (Murine) Monoclonal CLEC10A Primary Antibody for FACS - ABIN181063
Lederle, Hartenstein, Meides, Kunzelmann, Werb, Angel, Mueller: MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma. in Carcinogenesis 2010
Show all 3 references for ABIN181063
Mouse (Murine) Monoclonal CLEC10A Primary Antibody for Func, FACS - ABIN181064
Leenen, de Bruijn, Voerman, Campbell, van Ewijk: Markers of mouse macrophage development detected by monoclonal antibodies. in Journal of immunological methods 1994
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Human Polyclonal CLEC10A Primary Antibody for EIA, FACS - ABIN951291
Adéchian, Giardina, Rémond, Papet, Buonocore, Gaudichon, Dardevet, Marzatico, Mosoni: Excessive energy intake does not modify fed-state tissue protein synthesis rates in adult rats. in Obesity (Silver Spring, Md.) 2009
Show all 2 references for ABIN951291
BRAF (show BRAF Antibodies)(V600E) mutation induces MGL ligand expression, thereby providing a direct link between oncogenic transformation and aberrant expression of immunosuppressive glycans in colorectal neoplasms.
These results indicate a role of MGL as an immunomodulator within the tumour microenvironment interfering with Treg functions, suggesting its possible use in the design of anticancer vaccines.
expression of GalNAc moieties mirrors the T cell activation status, and thus only highly stimulated T cells are prone to the suppressive action of MGL.
MGL triggering synergized with TLR2 (show TLR2 Antibodies)-induced pathways, leading to elevated IL-10 (show IL10 Antibodies) mRNA levels & enhanced TNF-alpha (show TNF Antibodies) mRNA stability. It promoted phosphorylation of the ERK (show EPHB2 Antibodies) & CREB (show CREB1 Antibodies), fine-tuning the DC maturation phenotype.
Described is the use of recombinant CLEC10A (CD301), a human glycoreceptor of the C-type lectin (show MBL2 Antibodies) family, for the detection of ligands in sections from formalin-fixed, paraffin-embedded normal and cancerous mammary tissues.
MGL engagement improved DC performance as antigen-presenting cells, promoting the upregulation of maturation markers, a decrease in phagocytosis, an enhancement of motility, and most importantly an increase in antigen-specific CD8 (show CD8A Antibodies)(+) T-cell activation.
Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia
Mgl1 (show LLGL1 Antibodies)-deficient mice displayed accelerated colonic propulsion and were hypersensitive to mu receptor-mediated inhibition of colonic motility.
MGL1 (show LLGL1 Antibodies) is involved in T. crassiceps recognition and subsequent innate immune activation and resistance.
The MGL1 (show LLGL1 Antibodies) functions as an attachment and entry receptor for influenza A virus.
Syk (show SYK Antibodies) was involved in the CLR (show CALCR Antibodies)-mediated activation of mast cells by BP
Hoxc8 (show HOXC8 Antibodies) downregulates Mgl1 (show LLGL1 Antibodies) tumor suppressor gene expression and reduces its concomitant function on cell adhesion.
The authors conclude that lectin-mediated interactions of influenza virus with the MMR (show MRC1 Antibodies) or the MGL are required for the endocytic uptake of the virus into macrophages.
mMGL1 preferentially binds Lewis X (show FUT4 Antibodies)-conjugated soluble polyacrylamides
Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins.
sialoadhesin (show SIGLEC1 Antibodies) acts as an endogenous counter-receptor for MGL1 (show LLGL1 Antibodies)
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene.
C-type lectin domain family 10, member A
, C-type lectin, superfamily member 14
, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 13 (macrophage-derived)
, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 14 (macrophage-derived)
, C-type lectin domain family 10 member A
, macrophage lectin 2 (calcium dependent)
, macrophage asialoglycoprotein-binding protein 1
, macrophage galactose N-acetyl-galactosamine specific lectin 1
, Gal/GalNAc-specific lectin
, macrophage galactose/N-acetylgalactosamine-specific lectin
, monoglyceride lipase