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CLEC2D encodes a member of the natural killer cell receptor C-type lectin family. Additionally we are shipping CLEC2D Proteins (10) and CLEC2D Kits (2) and many more products for this protein.
Showing 10 out of 65 products:
Human Monoclonal CLEC2D Primary Antibody for IHC (p), ELISA - ABIN565412
Roth, Mittelbronn, Wick, Meyermann, Tatagiba, Weller: Malignant glioma cells counteract antitumor immune responses through expression of lectin-like transcript-1. in Cancer research 2007
Show all 5 references for ABIN565412
Human Monoclonal CLEC2D Primary Antibody for FACS - ABIN4897676
Chalan, Bijzet, Huitema, Kroesen, Brouwer, Boots: Expression of Lectin-Like Transcript 1, the Ligand for CD161, in Rheumatoid Arthritis. in PLoS ONE 2015
Human Monoclonal CLEC2D Primary Antibody for FACS - ABIN4897677
Dupuy, Lambert, Zucman, Choukem, Tognarelli, Pages, Lebbé, Caillat-Zucman: Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma. in PLoS pathogens 2012
Data suggest that killer cell lectin-like receptors NKR (show TACR3 Antibodies)-P1B:Clr-b (Klrb1 (show KLRB1 Antibodies):Clec2d) interactions may provide a model for human hematopoietic cell transplants.
Reductions of Clr-b may be involved in sensitizing poxvirus-infected cells to natural killer (NK) cells.
LLT1 and CD161 have roles in modulating immune responses to pathogens; and interferon-gamma (show IFNG Antibodies) contributes to modulate immune responses
cloning and characterization of a cognate ligand, Ocil, for the inhibitory NK receptors (NKR)-P1B and NKR-P1D. Ocil/Clr-b is displayed at high levels on nearly all hematopoietic cells, in a pattern that is similar to that of class I MHC molecules.
Data show that osteoclast inhibitory lectin (OCIL) binds a range of physiologically important glycosaminoglycans, and this property may modulate OCIL actions upon other cells.
Limited divergence of the BALB/c Nkrp1-Ocil/Clr region helps explain a longstanding confusion regarding the strain-specific NK1.1 alloantigen reactivity of mouse natural killer cells.
OCIL is a physiological negative regulator of bone.
PTHrp (show PTHLH Antibodies)(1-34) regulates OCIL expression in vitro through cAMP/PKA, Ca(2 (show CA2 Antibodies)+)/CaMK II (show CAMK2B Antibodies), and MAPK (show MAPK1 Antibodies) signaling pathways.
Identification of a novel family of genes, named Clr (show CALCR Antibodies), encoding C-type lectin-like molecules, which maps in the natural killer (NK) gene complex (NKC) on mouse Chromosome 6.
Mouse Nkrp1d and Nkrp1f bind specific C-type lectin-related (Clr (show CALCR Antibodies)) molecules. Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages. Nkrp1 and Clr (show CALCR Antibodies) are intertwined in a genetically conserved NKC region.
these data suggest that LLT1-CD161 (show KLRB1 Antibodies) interactions play a novel and important role in B cell maturation (show TNFRSF17 Antibodies) within the Germinal center in humans.
In RA joints, LLT1 is expressed by cells of the monocyte/macrophage lineage.
The hexamer of glycosylated LLT1 consists of three classical dimers. The hexameric packing may indicate a possible mode of interaction of C-type lectin (show MBL2 Antibodies)-like proteins in the glycosylated form.
One polymorphism in LLT1 was found to be associated with our Crohn's Disease population (P<0.034).Our Ulcerative Colitis cohort was not associated with the variation in LLT1 (P=0.33)
LLT1 and CD161 (show KLRB1 Antibodies) have roles in modulating immune responses to pathogens; and interferon-gamma (show IFNG Antibodies) contributes to modulate immune responses
Molecular basis for LLT1 protein recognition by human CD161 (show KLRB1 Antibodies) protein (NKRP1A/KLRB1 (show KLRB1 Antibodies)).
Data show that only CLEC2D isoform 1 (LLT1) is expressed on the cell surface.
LLT1 used Src (show SRC Antibodies)-PTK, p38 (show CRK Antibodies) and ERK (show EPHB2 Antibodies) signalling pathways, but not PKC (show PRRT2 Antibodies), PI3K (show PIK3CA Antibodies) or calcineurin (show PPP3CA Antibodies) pathways, to increase production of IFN-gamma (show IFNG Antibodies) by human natural killer cells.
LLT1 induces Interferon (show IFNA Antibodies) Type II production by natural killer cells.
Data show that osteoclast inhibitory lectin (OCIL) binds a range of physiologically important glycosaminoglycans, and this property may modulate OCIL actions upon other cells [OCIL].
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene.
osteoclast inhibitory lectin
, c-type lectin-like receptor
, C-type lectin domain family 2, member D
, C-type lectin domain family 2 member D
, C-type lectin-domain family 2 member D
, C-type lectin-related protein B
, lectin-like transmembrane protein
, C-type lectin related f
, C-type lectin superfamily 2, member D
, lectin-like NK cell receptor
, lectin-like transcript 1
, C-type lectin domain family 2 member D5