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Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis..
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CLEC-2 (show CLEC1B Proteins) is an adhesive receptor that supports platelet arrest to podoplanin (show PDPN Proteins) under venous shear. Src (show SRC Proteins)/Syk (show SYK Proteins)-dependent signalling stabilises platelet adhesion to podoplanin (show PDPN Proteins).
Both circulating B lymphocytes and CD11b (show ITGAM Proteins)-high Gr-1 (show GSR Proteins)-high myeloid cells lose CLEC-2 (show CLEC1B Proteins) following entry into secondary lymphoid organs.
aggretin may induce cytokine TNF-alpha (show TNF Proteins)/IL-6 (show IL6 Proteins) release via interacting with CLEC-2 (show CLEC1B Proteins) receptor and the subsequent MAPK (show MAPK1 Proteins) and NF-kappaB (show NFKB1 Proteins) activation in monocytes/macrophages
Data suggest that DDV10 is the long form of Clec2 (show CLEC1B Proteins) g (Clec2g-L), and DDV10/Clec2g-L may play a role in the stratification and/or cornification of epithelial cells during differentiation.
Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis.
C-type lectin domain family 2 member D11
, C-type lectin domain family 2, member d11
, C-type lectin-related protein 11
, C-type lectin-related protein B
, Ocil/Clrb-like protein
, lectin-like transmembrane protein
, osteoclast inhibitory lectin
, C-type lectin domain family 2 member G
, C-type lectin-related protein C
, C-type lectin-related protein x variant 1
, ocil-related protein 1
, osteoclast inhibitory lectin related protein
, osteoclast inhibitory lectin-related protein 1