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C1GALT1-Specific Chaperone 1 Proteins (C1GALT1C1)

C1GALT1C1 encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. Additionally we are shipping C1GALT1-Specific Chaperone 1 Antibodies (14) and C1GALT1-Specific Chaperone 1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
C1GALT1C1 29071 Q96EU7
C1GALT1C1 59048 Q9JMG2
C1GALT1C1 302499 Q499P3
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Top C1GALT1-Specific Chaperone 1 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,847.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,852.67
Details

C1GALT1C1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for C1GALT1-Specific Chaperone 1 (C1GALT1C1) Interaction Partners

Human C1GALT1-Specific Chaperone 1 (C1GALT1C1) interaction partners

  1. Data suggest that patients with IgA nephropathy exhibit higher microRNA-374b in B cells compared to controls; microRNA-374b appears to target PTEN (phosphatase and tensin homolog) and Cosmc (C1GALT1 specific chaperone 1) proteins.

  2. These results indicate that Tn antigens expression and T-synthase (show C1GALT1 Proteins) inactivity in HT-29-Tn+ cells can be related to the absence of the Cosmc gene coding sequence in Cosmc active alleles

  3. the impact of COSMC mediated Tn antigen expression in two human pancreatic ductal adenocarcinoma cell lines on cellular oncogenic properties, were investigated.

  4. hypermethylation of Cosmc promoter region could be a key mechanism for the reduction of Cosmc mRNA expression in IgAN lymphocytes with associated increase in aberrantly glycosylated IgA1

  5. Cosmc and T-synthase (show C1GALT1 Proteins) are transcriptionally regulated at a basal level by the specificity protein/Kruppel-like transcription factor (show KLF4 Proteins) family of members.

  6. CBRT is a unique recognition motif for Cosmc to promote its regulation and formation of active T-synthase (show C1GALT1 Proteins) and represents the first sequence-specific chaperone recognition system in the ER/Golgi required for normal protein O-glycosylation

  7. Data indicate that cytotoxin associated gene A protein (CagA (show S100A8 Proteins)) promoted the underglycosylation of IgA1, which at least partly attributed to the downregulation of beta1,3-galactosyltransferase (show GGTA1 Proteins) (C1GALT1 (show C1GALT1 Proteins)) and its chaperone Cosmc.

  8. overexpression of Cosmc is associated with colorectal cancer.

  9. COSMC is a novel regulator for VEGFR2 (show KDR Proteins) signaling in endothelial cells and dysregulation of COSMC expression may contribute to the pathogenesis of hemangioma

  10. The mRNA expression level of Cosmc gene in IgA nephropathy patients was significantly lower than that of controls. De-methylation modification up regulated the Cosmc gene expression significantly.

Mouse (Murine) C1GALT1-Specific Chaperone 1 (C1GALT1C1) interaction partners

  1. Cosmc is an essential chaperone for correct protein O-glycosylation.

  2. a somatic mutation in the chaperone gene Cosmc abolished function of a glycosyltransferase (show GTDC2 Proteins), disrupting O-glycan Core 1 synthesis & creating a tumor-specific glycopeptidic neo-epitope consisting of a monosaccharide and a specific wild-type protein sequence

C1GALT1-Specific Chaperone 1 (C1GALT1C1) Protein Profile

Protein Summary

This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene names and symbols associated with C1GALT1C1

  • C1GALT1-specific chaperone 1 (c1galt1c1)
  • C1GALT1-specific chaperone 1 (C1GALT1C1)
  • C1GALT1-specific chaperone 1 (C1galt1c1)
  • 1500002I11Rik protein
  • AB030184 protein
  • C1GalT2 protein
  • C38H2-L1 protein
  • C81205 protein
  • Cosmc protein
  • MGC88924 protein
  • MST143 protein
  • RGD1311230 protein
  • TNPS protein
  • wu:fc17f08 protein
  • wu:fc59b02 protein
  • zgc:66375 protein

Protein level used designations for C1GALT1C1

fc59b02 , core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 2 , C1GALT1-specific chaperone 1 , Core 1 beta3-galactosyltransferase-specific molecular chaperone , C1GALT1-specific chaperone 1-like , c1GALT1-specific chaperone 1-like , C1Gal-T2 , C38H2-like protein 1 , beta 1,3-galactosyltransferase 2 , core 1 beta1,3-galactosyltransferase 2 , core 1 beta3-Gal-T2 , core 1 beta3-galactosyltransferase-specific molecular chaperone , beta1,3-galactosyltransferase 2 , mC1Gal-T2

GENE ID SPECIES
324052 Danio rerio
422362 Gallus gallus
448225 Xenopus (Silurana) tropicalis
465837 Pan troglodytes
495031 Xenopus laevis
696662 Macaca mulatta
100397132 Callithrix jacchus
100441547 Pongo abelii
100594094 Nomascus leucogenys
29071 Homo sapiens
59048 Mus musculus
302499 Rattus norvegicus
531644 Bos taurus
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