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Cd2ap encodes a scaffolding molecule that regulates the actin cytoskeleton. Additionally we are shipping CD2-Associated Protein Antibodies (40) and CD2-Associated Protein Proteins (7) and many more products for this protein.
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Study found a novel association of CD2AP with plasma homocysteine in participants with African ancestry and found a new variant in the candidate gene CBS (show CBS ELISA Kits) associated with homocysteine
CD2AP rs9349407 polymorphism contributes to Alzheimer's disease susceptibility.
discovered novel interaction candidates for CD2AP and characterized subtle yet significant differences in the recognition preferences of its three SH3 domains for c-CBL (show CBL ELISA Kits), ALIX (show PDCD6IP ELISA Kits), and RIN3 (show RIN3 ELISA Kits)
we present the first demonstration that the purified SH3 domains of the CD2AP/Cin85 (show SH3KBP1 ELISA Kits) protein family are able to directly bind the p53 (show TP53 ELISA Kits) protein, and to discriminate between the two polymorphic variants P72R
CD2-Associated Protein affects Abeta (show APP ELISA Kits) levels and Abeta42/Abeta40 ratio in vitro
CD2AP gene variants may contribute to susceptibility to end-stage renal disease in patients with type 1 diabetes.
FSGS3/CD2AP has a role of barbed-end capping in junctional actin dynamics.
an FRS2beta (show FRS3 ELISA Kits)-CIN85 (show SH3KBP1 ELISA Kits)/CD2AP-Cbl (show CBL ELISA Kits) axis for downregulation of ErbB2 (show ERBB2 ELISA Kits) may regulate ErbB2 (show ERBB2 ELISA Kits) protein levels in physiological and pathological settings
E2F1 (show E2F1 ELISA Kits) up-regulates the human CD2AP promoter.
CD2AP is highly expressed in human plasmacytoid dendritic cells (DC) and positively regulates blood DC antigen 2 (BDCA2)/Fc fragment of IgE high affinity I receptor (FcepsilonR1gamma) signaling.
CD2AP forms a complex with GGA2 (show GGA2 ELISA Kits), a clathrin adaptor, which sorts Glut4 (show SLC2A4 ELISA Kits) to GSVs, suggesting a role for CD2AP in this process.
CD2AP is the first signaling molecule associated with adult sensory axonal collateral sprouting
CD2AP has role in mediating blood-brain barrier integrity and cerebrovascular roles of CD2AP could contribute to its effects on Alzheimer's disease risk.
only the SH3 domains of CD2AP are necessary to enhance the E3 ligase activity of Cbl-3 (show CBLC ELISA Kits)/c toward Ret51 (show RET ELISA Kits)
CD2AP is not involved in the regulation of type I IFNs in plasmacytoid dendritic cells. Its major function is on the actin cytoskeleton, affecting migration to local lymph nodes under conditions of inflammation.
CD2AP deficiency results in the excretion of intact albumin (show ALB ELISA Kits) in knockout mice.
the formation of lamellipodia is mediated by a complex of cortactin (show CTTN ELISA Kits), CD2AP, and actin capping protein (show TMOD4 ELISA Kits)
These data descrived the importance of concomitant decreases in podocin, CD2AP and tensin2 during septic acute renal failure-associated proteinuria.
Sh3kbp1 (show SH3KBP1 ELISA Kits) is SUMOylated by SUMO-1 (show SUMO1 ELISA Kits), -2, and -3 and that SUMOylation is enhanced in the presence of Cd2ap.
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
, Cas ligand with multiple Src homology 3 (SH3) domains
, adapter protein CMS
, cas ligand with multiple SH3 domains
, hypothetical protein
, SH3 domain-containing adapter protein
, SH3 domain-containing adaptor protein METS-1
, mesenchyme to epithelium transition protein, SH3 domains
, mesenchyme-to-epithelium transition protein with SH3 domains 1