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The protein encoded by CD46 is a type I membrane protein and is a regulatory part of the complement system. Additionally we are shipping CD46 Molecule, Complement Regulatory Protein Proteins (28) and CD46 Molecule, Complement Regulatory Protein Kits (20) and many more products for this protein.
Showing 10 out of 357 products:
Cow (Bovine) Monoclonal CD46 Primary Antibody for FACS, IP - ABIN616770
Gaggar, Shayakhmetov, Lieber: CD46 is a cellular receptor for group B adenoviruses. in Nature medicine 2003
Show all 14 references for ABIN616770
Human Monoclonal CD46 Primary Antibody for FACS - ABIN94153
Oliaro, Pasam, Waterhouse, Browne, Ludford-Menting, Trapani, Russell: Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 14 references for ABIN94153
Human Monoclonal CD46 Primary Antibody for FACS - ABIN94151
Liszewski, Kemper, Price, Atkinson: Emerging roles and new functions of CD46. in Springer seminars in immunopathology 2005
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Cow (Bovine) Monoclonal CD46 Primary Antibody for FACS - ABIN616771
Fleischli, Verhaagh, Havenga, Sirena, Schaffner, Cattaneo, Greber, Hemmi: The distal short consensus repeats 1 and 2 of the membrane cofactor protein CD46 and their distance from the cell membrane determine productive entry of species B adenovirus serotype 35. in Journal of virology 2005
Show all 14 references for ABIN616771
Human Monoclonal CD46 Primary Antibody for FACS, IP - ABIN94149
Marie, Astier, Rivailler, Rabourdin-Combe, Wild, Horvat: Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation. in Nature immunology 2002
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Human Monoclonal CD46 Primary Antibody for FACS - ABIN94152
Okada, Liszewski, Atkinson, Caparon: Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. in Proceedings of the National Academy of Sciences of the United States of America 1995
Show all 12 references for ABIN94152
Human Monoclonal CD46 Primary Antibody for FACS, IHC (fro) - ABIN111918
Johnstone, Russell, Loveland, McKenzie: Polymorphic expression of CD46 protein isoforms due to tissue-specific RNA splicing. in Molecular immunology 1993
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Human Polyclonal CD46 Primary Antibody for FACS, IF - ABIN650982
Weyand, Calton, Higashi, Kanack, So: Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection. in Journal of immunology (Baltimore, Md. : 1950) 2010
Show all 2 references for ABIN650982
Human Monoclonal CD46 Primary Antibody for FACS, IP - ABIN119580
Sirena, Lilienfeld, Eisenhut, Kälin, Boucke, Beerli, Vogt, Ruedl, Bachmann, Greber, Hemmi: The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3. in Journal of virology 2004
Human Polyclonal CD46 Primary Antibody for IP, IHC (p) - ABIN1999639
Miyaji, Paul, Shahrizaila, Umapathi, Yuki: Complement regulatory proteins (CD46, 55 and 59) expressed on Schwann cells: immune targets in demyelinating neuropathies? in Journal of neuroimmunology 2014
On the basis of these results, we propose a model in which dynamic vimentin filaments target CARMIL2 to critical membrane-associated locations, where CARMIL2 regulates CP, and thus actin assembly, to create cell protrusions
CD46 controls both Th1 (show TH1L Antibodies) activation and regulation via a miR (show MLXIP Antibodies)-150-dependent mechanism.
The composite biomarker, CAPG (show NCAPG Antibodies) and GIPC1 (show GIPC1 Antibodies) in primary breast tumors, predicted disease outcomes and benefit from zoledronate and may facilitate patient selection for adjuvant bisphosphonate treatment.
Data show that CD28 antigen (show CD28 Antibodies) costimulation modulates CD46 antigen surface expression on activated T cells.
This review summarizes our current knowledge of disease-associated mutations in this complement inhibitor(CD46).
It was not discover any association between A304V or other CD46 SNPs and preeclampsia.
gene deficiency results in defective Th1 (show TH1L Antibodies) cell induction due to failure in metabolic reprogramming
Each mutant C3b bound MCP at reduced affinity, providing a molecular basis for its reduced cofactor activity in atypical hemolytic uremic syndrome.
The mutations in the regulators CFH (show CFH Antibodies), CFI (show CFI Antibodies) and MCP involve loss-of-function, whereas those for C3 involve gain-of-function.
Results suggest a possible role for multidrug resistance genes ABCA10 (show ABCA10 Antibodies) and ABCA6 (show ABCA6 Antibodies) in follicular lymphoma survival and add to the evidence that genetic variation in CD46 and IL8 (show IL8 Antibodies) may have prognostic implications follicular lymphoma.
Changes in CD46 expression may lead to changes in VEGF and play a pathologic role in the development of age-related macular degeneration.
Our findings provide evidence for expression of CD46 in the mouse eye and a role for CD46 in protection against laser-induced choroidal neovascularization
This fusion is mediated by the interaction between viral glycoproteins expressed on the membrane of the infected cells and CD46 on the glial targets, and is also observed using cells expressing recombinant MV glycoproteins.
CD46 isoforms function as receptors for human herpesvirus 6 and measles virus
Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm and increased male fertility
CD46 has a role as a receptor for fusion and entry of human herpesvirus 6 into target cells
Study shows the existence of 10 distinct allelic versions of the CCP1 (show AGTPBP1 Antibodies) module of CD46; ectopic expression of the 10 bovine CD46 isoforms rendered the PK15 cells permissive to bovine viral diarrhea virus.
localization of CD46 on bovine sperm membrane
The results obtained in this study showed that both porcine CD46 and heparan sulfates play a major role in the initial steps of classical swine fever virus infection.
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
actin regulatory protein CAP-G
, actin-regulatory protein CAP-G
, gelsolin-like capping protein
, macrophage capping protein
, macrophage-capping protein
, membrane cofactor protein
, membrane cofactor protein(GMP1-full)
, CD46 antigen, complement regulatory protein
, antigen identified by monoclonal antibody TRA-2-10
, complement membrane cofactor protein
, measles virus receptor
, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
, trophoblast leucocyte common antigen
, trophoblast leukocyte common antigen
, trophoblast-lymphocyte cross-reactive antigen
, brain microvascular membrane cofactor