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CLK2 encodes a member of the CLK family of dual specificity protein kinases. Additionally we are shipping CLK2 Antibodies (97) and CLK2 Proteins (5) and many more products for this protein.
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Clk1 (show CDK11B ELISA Kits), Clk2 and Clk4 (show CLK4 ELISA Kits) prevent chromatin breakage by regulating the Aurora B (show AURKB ELISA Kits)-dependent abscission checkpoint.
Loss of CLK2 in luminal breast cancer cells leads to the upregulation of epithelial-to-mesenchymal transition (EMT (show ITK ELISA Kits))-related genes and a switch to mesenchymal splice variants of several genes.
LAMMER/Cdc2 (show CDK1 ELISA Kits)-like kinase, represented by Doa and its mammalian homolog CLK2, is a critical and conserved component in the regulatory program of the mitosis-to-meiosis switch
CLK1 (show CDK11B ELISA Kits) Increases While CLK2 Decreases HIV-1 Gene Expression.
AKT (show AKT1 ELISA Kits) activation controls cell survival to ionizing radiation by phosphorylating CLK2, revealing an important regulatory mechanism required for promoting cell survival.
Cdc2 (show CDK1 ELISA Kits)-like kinases and DNA topoisomerase I (show TOP1 ELISA Kits) regulate alternative splicing of tissue factor (show F3 ELISA Kits) in human endothelial cells.
Liver-specific Clk2 knockout mice fed a high-fat diet exhibit increased fasting levels of blood ketone bodies, reduced respiratory exchange ratio, and increased gene expression of fatty acid oxidation and ketogenic pathways.
Cdc2 (show CDK1 ELISA Kits)-like kinase 2 (Clk2) directly phosphorylates the SR domain on PGC-1alpha (show PPARGC1A ELISA Kits), resulting in repression of gluconeogenic gene expression and hepatic glucose output.
This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have been shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. Note that this gene is distinct from TELO2 gene (GeneID:9894), which shares CLK2 and hCLK2 symbol aliases in common with this gene, but encodes a protein that is involved in telomere length regulation.
CDC-like kinase 2
, dual specificity protein kinase CLK2
, CLK kinase
, Clk2-Scamp3 protein