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CMTM3 belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. Additionally we are shipping CMTM3 Antibodies (16) and many more products for this protein.
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Reduced expression of CMTM3 is associated with prostate cancer.
CMTM1 and 3 are priority targets in glioblastomas. First insights into signalling of these two genes that might be conveyed by growth factor receptor (show RYK Proteins), Src (show SRC Proteins) family kinase and WNT (show WNT2 Proteins) activation was presented.
Low expression of CMTM3 was associated with metastasis and recurrence of oral squamous cell carcinoma.
CMTM3 is significantly down-regulated in clear cell renal cell carcinoma (show MOK Proteins) and exerts remarkable tumor-suppressive functions
Peritoneal disseminated metastases were significantly suppressed by CMTM3.
Bioinformatics based on CKLF2 cDNA and protein sequences in combination with experimental validation identified CKLFSF1-8 gene clusters, between the SCY and the TM4SF (show TSPAN1 Proteins) gene families. The 8 family members were cloned and characterized.
CMTM3/CKLFSF3 is an evolutionarily conserved gene that may have important roles in the male reproductive system and immune system.
CMTM3 inhibits prostate-specific antigen (show KLK3 Proteins) expression at both mRNA and protein levels with no obvious influence on androgen receptor (show AR Proteins) expression.
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified.
CKLF-like MARVEL transmembrane domain-containing protein 3
, chemokine-like factor super family 3
, CKLF-like MARVEL transmembrane domain containing 3
, chemokine-like factor superfamily member 3