Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Additionally we are shipping CRTC1 Antibodies (79) and CRTC1 Proteins (7) and many more products for this protein.
High TORC1 expression is associated with meningioma and schwannoma.
MECT1-MAML2 fusion transcript is a driver genetic event in the pathogenesis of primary bronchopulmonary mucoepidermoid carcinoma
CRTC1 as new mediator of PGE2 signaling
Consistent with our findings in Drosophila, through the characterization of a wdr24-/- knockout HeLa cell line we determined that Wdr24 promotes lysosome acidification and autophagic flux in mammalian cells
revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions in cutaneous hidradenoma
CRTC1 polymorphisms seem to play a role with obesity markers in individuals with MDD rather than non-depressive individuals.
DNA methylation (show HELLS ELISA Kits) levels within two distinct promoter regions of the CREB regulated transcription coactivator 1 gene were decreased in human hippocampus affected by Alzheimer disease.
Detection of the CRTC1/MAML2 fusion transcript provides useful information for MEC (show CCL28 ELISA Kits) diagnosis but is not associated with differences in survival outcomes.
A specific CRTC1-MAMl2-induced transcriptional program was identified in mucoepidermoid carcinoma cells.
Translocation t(11;19)(q14-21;p12 (show POLE4 ELISA Kits)-13) in patients with Salivary mucoepidermoid carcinoma was reported , which results in fusion between exons 1 and 2 of CRTC1 on chromosome 19p13.
Deletion of Raptor (show RPTOR ELISA Kits) reduced the size of limb bud cells, resulting in overall diminution of the limb bud without affecting skeletal patterning. We then examined the potential role of mTORC1 in chondrogenic differentiation in vitro.
Three mouse CRTCs (Crtc1, Crtc2 (show CRTC2 ELISA Kits) and Crtc3 (show CRTC3 ELISA Kits)) exhibit distinct patterns of 14-3-3 (show YWHAQ ELISA Kits) binding at three conserved sites corresponding to S70, S171 (show NUMB ELISA Kits), and S275 (in CRTC2 (show CRTC2 ELISA Kits)).
The NR2B (show GRIN2B ELISA Kits)-CREB (show CREB1 ELISA Kits)-miR212/132-CRTC1-CREB (show CREB1 ELISA Kits) signal network plays an important role in the regulation of pain.
Findings reveal a critical role of CREB-regulated transcription coactivator 1 (CRTC1) in the hippocampus during associative memory, and provide evidence that CRTC1 deregulation underlies memory deficits during neurodegeneration.
Analysis of the successful model also elucidates two dynamical motifs: neutralization of a negative regulator, which characterizes how Akt (show AKT1 ELISA Kits) indirectly activates mTORC1, and seesaw enzyme regulation, which describes how activated and inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response
Study suggests that CRTC1 is a key regulator of behavioral and molecular response to antidepressant: CRTC1 is required for complete behavioral antidepressant response and for desipramine-induced expression of Bdnf (show BDNF ELISA Kits) and Nr4a1 (show NR4A1 ELISA Kits)-2. By acting downstream of CRTC1, the HDAC (show HDAC3 ELISA Kits) inhibitor SAHA improves the depressive-like behavior of Crtc1-/- mice.
IL-4 (show IL4 ELISA Kits) signaling co-opts the Akt (show AKT1 ELISA Kits)-mTORC1 pathway to regulate Acly (show ACLY ELISA Kits), a key enzyme in acetyl-CoA (show LPCAT1 ELISA Kits) synthesis, leading to increased histone acetylation and macrophage gene induction.
Upregulation of CRTC1 enhancing CREB (show CREB1 ELISA Kits)-dependent gene transcription in spinal cord may play an important role in bone cancer pain.
This study demonstrates that TSC1 (show TSC1 ELISA Kits)- mechanistic target of rapamycin (show FRAP1 ELISA Kits) complex 1 (mTORC1) signaling contributes to the brown-to-white adipocyte phenotypic switch.[mTORC1]
These data identify Notch (show NOTCH1 ELISA Kits) as a therapeutically actionable branch point of metabolic signaling at which Akt (show AKT1 ELISA Kits) activation in the liver can be uncoupled from hepatosteatosis.[mTORC1]
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.
CREB-regulated transcription coactivator 1
, mucoepidermoid carcinoma translocated 1
, CREB regulated transcription coactivator 1
, CREB-regulated transcription coactivator 1-like
, mucoepidermoid carcinoma translocated protein 1
, transducer of regulated cAMP response element-binding protein (CREB) 1
, mucoepidermoid carcinoma translocated protein 1 homolog
, transducer of CREB protein 1
, transducer of regulated cAMP response element-binding protein 1