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CLEC14A encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Additionally we are shipping CLEC14A Proteins (7) and CLEC14A Kits (1) and many more products for this protein.
Showing 10 out of 52 products:
Human Polyclonal CLEC14A Primary Antibody for FACS, ICC - ABIN4899675
Ki, Jeoung, Choi, Rho, Kwon, Shim, Chung, Hong, Song, Lee: Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro. in Oncogene 2013
Show all 2 references for 4899675
Mouse (Murine) Polyclonal CLEC14A Primary Antibody for ELISA - ABIN2000723
Zelensky, Gready: The C-type lectin-like domain superfamily. in The FEBS journal 2005
The CLEC14A-MMRN2 (show MMRN2 Antibodies) interaction is involved in sprouting angiogenesis. Disrupting this interaction with monoclonal antibodies directed against CLEC14A show anti-angiogenic and anti-tumor effects.
CLEC14A is a matrix component which binds to MMRN2 (show MMRN2 Antibodies) in the process of endothelial cells transformation in tumor angiogenesis.
clec14a-CTLD may be a key domain in angiogenesis
In this study, they identify and characterize a novel tumor endothelial marker, CLEC14A, which has properties that suggest it is a candidate for tumor vascular targeting and anti-angiogenic approaches.
CLEC14A acts in vascular homeostasis by fine-tuning VEGFR-2 (show KDR Antibodies) and VEGFR-3 (show FLT4 Antibodies) signaling in endothelial cells
These findings demonstrate that Clec14a is a novel endothelial cells specific protein that appears to play a role in cell-cell adhesion and angiogenesis.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting.
C-type lectin domain family 14 member A
, ClECT and EGF-like domain containing protein
, epidermal growth factor receptor 5