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CLEC14A Products

(C-Type Lectin Domain Family 14, Member A (CLEC14A))

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This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012].

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Featured CLEC14A Categories

CLEC14A Antibodies

High quality antibodies with extensive validation data.

CLEC14A ELISA Kits

Reliable ELISA kits for a wide range of species.

CLEC14A Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CLEC14A Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF (p), IHC (p)
Validations
  • (3)
  • (1)
Cat. No. ABIN1385496
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (3)
Cat. No. ABIN531111
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7146053
Quantity 100 μg
Datasheet Datasheet

Recommended CLEC14A ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4882375
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730716
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6386088
Quantity 96 tests
Datasheet Datasheet

Recommended CLEC14A Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7274362
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7274351
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122062
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our CLEC14A products

Kim, Park, Jang, Kim, Na, Lee, Kim, Heo, Yoo, Kim, Lee, Kim, Kim, Kim, Cha, Lee, Lee: "Inhibition of VEGF-dependent angiogenesis and tumor angiogenesis by an optimized antibody targeting CLEC14a." in: Molecular oncology, Vol. 12, Issue 3, pp. 356-372, (2019) (PubMed).

Botting, Bertram, Baharlou, Sandgren, Fletcher, Rhodes, Rana, Plasto, Wang, Lim, Barnouti, Kohout, Papadopoulos, Merten, Olbourne, Cunningham, Haniffa, Harman: "Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes." in: Journal of leukocyte biology, Vol. 101, Issue 6, pp. 1393-1403, (2017) (PubMed).

Jang, Kim, Kim, Lee, Kim, Heo, Lee: "CLEC14a-HSP70-1A interaction regulates HSP70-1A-induced angiogenesis." in: Scientific reports, Vol. 7, Issue 1, pp. 10666, (2017) (PubMed).

Noy, Swain, Khan, Lodhia, Bicknell: "Sprouting angiogenesis is regulated by shedding of the C-type lectin family 14, member A (CLEC14A) ectodomain, catalyzed by rhomboid-like 2 protein (RHBDL2)." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 30, Issue 6, pp. 2311-23, (2016) (PubMed).

Noy, Lodhia, Khan, Zhuang, Ward, Verissimo, Bacon, Bicknell: "Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth." in: Oncogene, (2015) (PubMed).

Ki, Jeoung, Choi, Rho, Kwon, Shim, Chung, Hong, Song, Lee: "Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro." in: Oncogene, Vol. 32, Issue 48, pp. 5449-57, (2013) (PubMed).

Mura, Swain, Zhuang, Vorschmitt, Reynolds, Durant, Beesley, Herbert, Sheldon, Andre, Sanderson, Glen, Luu, McGettrick, Antczak, Falciani, Nash, Nagy, Bicknell: "Identification and angiogenic role of the novel tumor endothelial marker CLEC14A." in: Oncogene, Vol. 31, Issue 3, pp. 293-305, (2012) (PubMed).

Galvagni, Nardi, Spiga, Trezza, Tarticchio, Pellicani, Andreuzzi, Caldi, Toti, Tosi, Santucci, Iozzo, Mongiat, Orlandini: "Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium." in: Matrix biology : journal of the International Society for Matrix Biology, Vol. 64, pp. 112-127 (PubMed).

Synonyms and alternative names related to CLEC14A

C-type lectin domain containing 14A (CLEC14A), C-type lectin domain family 14, member a (Clec14a), 1200003C23Rik, AI642649, C14orf27, CEG1, EGFR-5

Protein level used designations for CLEC14A

  • C-type lectin domain family 14 member A
  • ClECT and EGF-like domain containing protein
  • epidermal growth factor receptor 5
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