anti-C-Type Lectin Domain Family 6, Member A (CLEC6A) Antibodies

Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Additionally we are shipping C-Type Lectin Domain Family 6, Member A Proteins (10) and C-Type Lectin Domain Family 6, Member A Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLEC6A 56620 Q9JKF4
CLEC6A 93978 Q6EIG7
CLEC6A    
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Top anti-C-Type Lectin Domain Family 6, Member A Antibodies at antibodies-online.com

Showing 10 out of 153 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Rat FITC FACS   25 μg Log in to see 6 to 8 Days
$198.00
Details
Mouse Rat Un-conjugated FACS, IHC (fro), IP   25 μg Log in to see 6 to 8 Days
$176.00
Details
Human Mouse Un-conjugated FACS Detection of Dectin-2/CLEC6A in Human Monocytes by Flow Cytometry. Human blood-derived monocytes were stained with Mouse Anti-Human Dectin-2/CLEC6A Monoclonal Antibody. 100 μg Log in to see 8 to 9 Days
$273.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CLEC6A Antibody Titration: 0.2-1 ug/mlPositive Control: THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated FACS, IHC, WB 100 μg Log in to see 2 to 3 Days
$260.00
Details
Human Mouse Fluorescein FACS Detection of Dectin-2/CLEC6A in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Mouse Anti-Human Dectin-2/CLEC6A Fluorescein-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$267.75
Details
Human Mouse PE FACS Detection of Dectin-2/CLEC6A in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Mouse Anti-Human Dectin-2/CLEC6A PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$320.25
Details
Human Rabbit Un-conjugated WB CLEC6A Antibody (C-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the CLEC6A antibody detected the CLEC6A protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Alexa Fluor 700 FACS Detection of Dectin-2/CLEC6A in Human PBMCs Monocytes by Flow Cytometry. Human peripheral blood mononuclear cell (PBMC) monocytes were stained with Mouse Anti-Human Dectin-2/CLEC6A Alexa Fluor 700-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$341.25
Details
Human Mouse Allophycocyanin FACS Detection of Dectin-2/CLEC6A in Human PBMC Monocytes by Flow Cytometry. Human peripheral blood mononuclear cell (PBMC) monocytes were stained with (A) Mouse Anti-Human CD14 PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$372.75
Details

CLEC6A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-C-Type Lectin Domain Family 6, Member A Antibodies

  1. Mouse (Murine) Monoclonal CLEC6A Primary Antibody for FACS, IHC (fro) - ABIN320277 : Taylor, Reid, Heinsbroek, Brown, Gordon, Wong: Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo. in European journal of immunology 2005 (PubMed)
    Show all 3 references for 320277

  2. Human Monoclonal CLEC6A Primary Antibody for FACS - ABIN4900356 : Gringhuis, Wevers, Kaptein, van Capel, Theelen, Boekhout, de Jong, Geijtenbeek: Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2. in PLoS pathogens 2011 (PubMed)

More Antibodies against C-Type Lectin Domain Family 6, Member A Interaction Partners

Mouse (Murine) C-Type Lectin Domain Family 6, Member A (CLEC6A) interaction partners

  1. a glycosylated protein with mannose-related structure is recognized by Dectin-2 in dendritic cells

  2. Dectin-2 does not play a major role in in phagocytosis and innate defense by phagocytes against Cryptococcus neoformans spores.

  3. activation of CLRs Dectin-2 and Dectin-3 by fungi infections triggers them for ubiquitination and degradation in a Syk (show SYK Antibodies)-dependent manner.

  4. this study shows that in vitro, cytokine production by bone marrow-derived dendritic cells is dependent on dectin-2; in vivo, its deficiency compromises fungal clearance

  5. these data indicate that mannosylated O-antigens from several Gram-negative bacteria augment TLR4 (show TLR4 Antibodies) responses through interaction with Dectin-2.

  6. Dectin-2 leads to an increase in cardiac rupture, impairs wound healing, and aggravates cardiac remodeling after MI through the modulation of Th1 (show HAND1 Antibodies) differentiation.

  7. this study demonstrates the role of Dectin-2 as an essential trigger of host defense in a murine model of systemic candidiasis

  8. The results indicate differential roles for Dectin-2 and Mincle (show CLEC4E Antibodies) in the generation of adaptive immune responses to F. pedrosoi fungal infection in mice.

  9. Dectin-2 may oppose the Th2 response and IL-4 (show IL4 Antibodies)-dependent mucin (show SLC13A2 Antibodies) production in the lungs after infection with C. neoformans, and it may not be required for the production of Th1 (show HAND1 Antibodies), Th17, and proinflammatory cytokines or for clearance of this fungal pathogen.

  10. our data show a requirement for Dectin-2 in alveolar macrophage induction of cysteinyl leukotrienes and in the initiation of airway inflammation.

Human C-Type Lectin Domain Family 6, Member A (CLEC6A) interaction partners

  1. Data suggest that the specificity and geometry of dectin-2/CLEC6A carbohydrate-binding site provide molecular mechanism for binding of dectin-2 to fungal mannans and also to bacterial lipopolysaccharides, capsular polysaccharides, and lipoarabinomannans that contain mannose-alpha-1--2-mannose disaccharide unit. (CLEC6A = C-type lectin (show MBL2 Antibodies) domain containing 6A)

  2. these data indicate that mannosylated O-antigens from several Gram-negative bacteria augment TLR4 (show TLR4 Antibodies) responses through interaction with Dectin-2.

  3. This study showed a genetic association between Dectin-2 and pulmonary cryptococcosis.

  4. human plasmacytoid dendritic cells directly recognize A. fumigatus hyphae via Dectin-2

  5. our data show a requirement for Dectin-2 in alveolar macrophage induction of cysteinyl leukotrienes and in the initiation of airway inflammation.

  6. The Dectin-2 possess a single extracellular conserved C-type lectin (show MBL2 Antibodies)-like domain and are capable of mediating intracellular signalling either directly, through integral signalling domains, or indirectly, by associating with signalling adaptor molecules.

  7. Thus, dectin-1 (show CLEC7A Antibodies) and dectin-2 control adaptive T(H)-17 immunity to fungi via Malt1 (show MALT1 Antibodies)-dependent activation of c-Rel (show NFkBP65 Antibodies).

  8. human DECTIN-2 has a role in innate immunity

C-Type Lectin Domain Family 6, Member A (CLEC6A) Antigen Profile

Protein Summary

Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functionnal receptor for alpha-mannans on C. albicans hypheas. Plays an important role in the host defense against C. albicans infection by inducing TH17 cell differentiation. Recognizes also, in a manose dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway.

Gene names and symbols associated with CLEC6A

  • C-type lectin domain family 6, member A (CLEC6A) antibody
  • C-type lectin domain family 4, member n (Clec4n) antibody
  • CLEC4N antibody
  • Clec6a antibody
  • CLECSF10 antibody
  • Nkcl antibody

Protein level used designations for CLEC6A

C-type lectin domain family 6, member A , C-type lectin domain family 6 member A , dectin-2 , C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10 , C-type lectin superfamily member 10 , DC-associated C-type lectin 2 , dendritic cell-associated C-type lectin 2 , natural killer complex lectin , C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10 , dectin 2

GENE ID SPECIES
678675 Ovis aries
735479 Pan troglodytes
56620 Mus musculus
93978 Homo sapiens
514979 Bos taurus
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