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Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Additionally we are shipping C-Type Lectin Domain Family 6, Member A Proteins (10) and C-Type Lectin Domain Family 6, Member A Kits (1) and many more products for this protein.
Showing 10 out of 153 products:
Mouse (Murine) Monoclonal CLEC6A Primary Antibody for FACS, IHC (fro) - ABIN320277
Taylor, Reid, Heinsbroek, Brown, Gordon, Wong: Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo. in European journal of immunology 2005
Show all 3 references for 320277
Human Monoclonal CLEC6A Primary Antibody for FACS - ABIN4900356
Gringhuis, Wevers, Kaptein, van Capel, Theelen, Boekhout, de Jong, Geijtenbeek: Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2. in PLoS pathogens 2011
a glycosylated protein with mannose-related structure is recognized by Dectin-2 in dendritic cells
Dectin-2 does not play a major role in in phagocytosis and innate defense by phagocytes against Cryptococcus neoformans spores.
activation of CLRs Dectin-2 and Dectin-3 by fungi infections triggers them for ubiquitination and degradation in a Syk (show SYK Antibodies)-dependent manner.
this study shows that in vitro, cytokine production by bone marrow-derived dendritic cells is dependent on dectin-2; in vivo, its deficiency compromises fungal clearance
these data indicate that mannosylated O-antigens from several Gram-negative bacteria augment TLR4 (show TLR4 Antibodies) responses through interaction with Dectin-2.
Dectin-2 leads to an increase in cardiac rupture, impairs wound healing, and aggravates cardiac remodeling after MI through the modulation of Th1 (show HAND1 Antibodies) differentiation.
this study demonstrates the role of Dectin-2 as an essential trigger of host defense in a murine model of systemic candidiasis
The results indicate differential roles for Dectin-2 and Mincle (show CLEC4E Antibodies) in the generation of adaptive immune responses to F. pedrosoi fungal infection in mice.
Dectin-2 may oppose the Th2 response and IL-4 (show IL4 Antibodies)-dependent mucin (show SLC13A2 Antibodies) production in the lungs after infection with C. neoformans, and it may not be required for the production of Th1 (show HAND1 Antibodies), Th17, and proinflammatory cytokines or for clearance of this fungal pathogen.
our data show a requirement for Dectin-2 in alveolar macrophage induction of cysteinyl leukotrienes and in the initiation of airway inflammation.
Data suggest that the specificity and geometry of dectin-2/CLEC6A carbohydrate-binding site provide molecular mechanism for binding of dectin-2 to fungal mannans and also to bacterial lipopolysaccharides, capsular polysaccharides, and lipoarabinomannans that contain mannose-alpha-1--2-mannose disaccharide unit. (CLEC6A = C-type lectin (show MBL2 Antibodies) domain containing 6A)
This study showed a genetic association between Dectin-2 and pulmonary cryptococcosis.
human plasmacytoid dendritic cells directly recognize A. fumigatus hyphae via Dectin-2
The Dectin-2 possess a single extracellular conserved C-type lectin (show MBL2 Antibodies)-like domain and are capable of mediating intracellular signalling either directly, through integral signalling domains, or indirectly, by associating with signalling adaptor molecules.
Thus, dectin-1 (show CLEC7A Antibodies) and dectin-2 control adaptive T(H)-17 immunity to fungi via Malt1 (show MALT1 Antibodies)-dependent activation of c-Rel (show NFkBP65 Antibodies).
human DECTIN-2 has a role in innate immunity
Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functionnal receptor for alpha-mannans on C. albicans hypheas. Plays an important role in the host defense against C. albicans infection by inducing TH17 cell differentiation. Recognizes also, in a manose dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway.
C-type lectin domain family 6, member A
, C-type lectin domain family 6 member A
, C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10
, C-type lectin superfamily member 10
, DC-associated C-type lectin 2
, dendritic cell-associated C-type lectin 2
, natural killer complex lectin
, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10
, dectin 2