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C-Type Lectin Domain Family 6, Member A Products

(C-Type Lectin Domain Family 6, Member A (CLEC6A))
Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functionnal receptor for alpha-mannans on C. albicans hypheas. Plays an important role in the host defense against C. albicans infection by inducing TH17 cell differentiation. Recognizes also, in a manose dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway.

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Featured C-Type Lectin Domain Family 6, Member A Categories

C-Type Lectin Domain Family 6, Member A Antibodies

High quality antibodies with extensive validation data.

C-Type Lectin Domain Family 6, Member A ELISA Kits

Reliable ELISA kits for a wide range of species.

C-Type Lectin Domain Family 6, Member A Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended C-Type Lectin Domain Family 6, Member A Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7186528
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, FACS, IHC (p)
Validations
  • (3)
Cat. No. ABIN959984
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, ICC
Validations
  • (2)
Cat. No. ABIN6260891
Quantity 100 μL
Datasheet Datasheet

Recommended C-Type Lectin Domain Family 6, Member A ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4882590
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730425
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6385418
Quantity 96 tests
Datasheet Datasheet

Recommended C-Type Lectin Domain Family 6, Member A Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7320341
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
Cat. No. ABIN2745635
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3115618
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our C-Type Lectin Domain Family 6, Member A products

Botting, Bertram, Baharlou, Sandgren, Fletcher, Rhodes, Rana, Plasto, Wang, Lim, Barnouti, Kohout, Papadopoulos, Merten, Olbourne, Cunningham, Haniffa, Harman: "Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes." in: Journal of leukocyte biology, Vol. 101, Issue 6, pp. 1393-1403, (2017) (PubMed).

Brasch, Mörig, Neumann, Proksch: "Expression of antimicrobial peptides and toll-like receptors is increased in tinea and pityriasis versicolor." in: Mycoses, Vol. 57, Issue 3, pp. 147-52, (2014) (PubMed).

Barrett, Rahman, Fernandez, Parsons, Xing, Austen, Kanaoka: "Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes." in: The Journal of experimental medicine, Vol. 208, Issue 3, pp. 593-604, (2011) (PubMed).

Gringhuis, Wevers, Kaptein, van Capel, Theelen, Boekhout, de Jong, Geijtenbeek: "Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2." in: PLoS pathogens, Vol. 7, Issue 1, pp. e1001259, (2011) (PubMed).

Suram, Gangelhoff, Taylor, Rosas, Brown, Bonventre, Akira, Uematsu, Williams, Murphy, Leslie: "Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans." in: The Journal of biological chemistry, Vol. 285, Issue 40, pp. 30676-85, (2010) (PubMed).

Taylor, Reid, Heinsbroek, Brown, Gordon, Wong: "Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo." in: European journal of immunology, Vol. 35, Issue 7, pp. 2163-74, (2005) (PubMed).

Synonyms and alternative names related to C-Type Lectin Domain Family 6, Member A

C-type lectin domain containing 6A (CLEC6A), C-type lectin domain family 6, member A (Clec6a), CLEC4N, CLEC6A, CLECSF10

Protein level used designations for C-Type Lectin Domain Family 6, Member A

  • C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10
  • C-type lectin domain family 6 member A
  • C-type lectin superfamily member 10
  • DC-associated C-type lectin 2
  • dectin 2
  • dectin-2
  • dendritic cell-associated C-type lectin 2
  • C-type lectin domain family 6, member A
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