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Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation (By similarity).. Additionally we are shipping CUEDC2 Antibodies (72) and CUEDC2 Kits (4) and many more products for this protein.
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Results suggest that decreased expression of CUEDC2 contributes to tumor growth in lung adenocarcinoma, leading to a poor clinical outcome.
CUEDC2 plays a crucial role in modulating macrophage function and is associated with both colitis and colon tumorigenesis.
High CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment.
In response to UV irradiation, CUEDC2 undergoes ERK1/2-dependent phosphorylation and ubiquitin-dependent degradation, leading to APC (show APC Proteins)/C(Cdh1 (show CDH1 Proteins))-mediated cyclin A (show CCNA2 Proteins) destruction, cyclin-dependent kinase 2 (show KKIAMRE Proteins) inactivation, and G1 arrest.
a new biological activity for CUEDC2 as the regulator of JAK1 (show JAK1 Proteins)/STAT3 (show STAT3 Proteins) signaling and the mechanism by which SOCS3 (show SOCS3 Proteins) has been linked to suppression of the JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) pathway
CUEDC2 is a cell-cycle regulator that promotes spindle checkpoint inactivation and releases APC (show APC Proteins)/C from checkpoint inhibition. CUEDC2 is phosphorylated by Cdk1 (show CDK1 Proteins) during mitosis.
These results identify a key post-translational mechanism that controls progesterone receptor (show PGR Proteins) protein levels and for the first time provide an important insight into the function of CUEDC2 in breast cancer proliferation.
These findings demonstrate that CUEDC2 plays an important role in protection from colonic inflammation, primarily by inhibiting the NF-kappaB (show NFKB1 Proteins) and STAT3 (show STAT3 Proteins) signaling pathways and preventing excessive proliferation of the inflammatory epithelial cell.
Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation (By similarity).
CUE domain-containing protein 2-A
, mitotic phosphoprotein 38
, CUE domain containing 2
, CUE domain-containing protein 2-B
, CUE domain-containing protein 2