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CUGBP, Elav-Like Family Member 1 Proteins (CELF1)

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Additionally we are shipping CELF1 Antibodies (80) and CELF1 Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CELF1 10658 Q92879
CELF1 13046 P28659
CELF1 362160 Q4QQT3
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Top CELF1 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,377.00
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,384.33
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,384.33
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$3,386.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CELF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced CELF1 Proteins

  1. Human CELF1 Protein expressed in Wheat germ - ABIN1350750 : Yu, Rao, Zou, Liu, Xiao, Ouyang, Cao, Gorospe, Wang: Competitive binding of CUGBP1 and HuR to occludin mRNA controls its translation and modulates epithelial barrier function. in Molecular biology of the cell 2013 (PubMed)

More Proteins for CUGBP, Elav-Like Family Member 1 (CELF1) Interaction Partners

Human CUGBP, Elav-Like Family Member 1 (CELF1) interaction partners

  1. CUG-BP1 affected the calcium release activity in single myofibers and the extent of atrophy was significantly reduced upon gene silencing of CUG-BP1 in atrophic muscle.

  2. these data provided a comprehensive view of the CELF1 mRNA regulatory network in oral cancer

  3. forced expression of miR (show MLXIP Proteins)-214-3p enhances the sensitivity of esophageal cancer cells to cisplatin-induced apoptosis. This effect is abrogated with rescue expression of survivin (show BIRC5 Proteins) or CUG-BP1

  4. Expression of several genes within the CELF1 locus, including MTCH2 (show MTCH2 Proteins), were highly correlated with one another and were associated with Alzheimer's disease status.

  5. CUGBP1 and HuR (show ELAVL1 Proteins) negate each other's effects in regulating E-cadherin (show CDH1 Proteins) translation by altering the recruitment of E-cadherin (show CDH1 Proteins) mRNA to PBs (show TSPO Proteins) and play important roles in the regulation of intestinal barrier integrity.

  6. CUGBP1 promotes cell proliferation and suppresses apoptosis via down-regulating C-EBPalpha (show CEBPA Proteins) in human non-small cell lung cancers.

  7. The results indicate that the cellular level of miR (show MLXIP Proteins)-122 is determined by the balance between the opposing effects of GLD-2 (show PAPD4 Proteins) and PARN (show PARN Proteins)/CUGBP1 on the metabolism of its 3'-terminus.

  8. CELF1 dysfunction in malignant T cells led to the up-regulation of a subset of GRE-containing transcripts that promote cell growth and down-regulation of another subset that suppress cell growth

  9. Celf1 has a role in vegetal RNA localization during Xenopus oogenesis

  10. These results demonstrate the importance of CUGBP1 in the biological and pathological functions of NSCLC and indicate its potential as a therapeutic target for NSCLC.

Mouse (Murine) CUGBP, Elav-Like Family Member 1 (CELF1) interaction partners

  1. CELF1 downregulates Cyp19a1 (Aromatase (show CYP19A1 Proteins)) posttranscriptionally to achieve high concentrations of testosterone compatible with spermiogenesis completion.

  2. developmental stage-specific compatibility of CELF (show CEBPD Proteins)-dependent splice variants dictates their effects on cardiac health and function

  3. Differential expression of CELF1 in development plays a role in alternative splicing of vesicular trafficking genes in postnatal heart development.

  4. Celf1 plays a distinctive and negative role in terminal myocyte differentiation, which partially contribute to DM1 RNA toxicity.

  5. These results indicate that JNK2 (show MAPK9 Proteins) is essential for maintenance of normal intestinal epithelial homeostasis and maturation under biological conditions by differentially modulating HuR (show ELAVL1 Proteins) and CUGBP1.

  6. CELF1 and CELF2 (show CELF2 Proteins) may underlie conserved, developmentally regulated, tissue-specific processes in vertebrate embryos

  7. Mitochondrial biogenesis occurs in the presence of increased CUG-BP1 and AUF1 (show HNRNPD Proteins), suggesting that reductions in known mRNA destabilizing proteins likely does not contribute to exercise-induced mitochondrial biogenesis.

  8. these results strongly support a role for -mediated alternative splicing in the regulation of contractile gene expression, achieved in part through modulating the activity of SRF, a key cardiac transcription factor.

  9. This review is focused on the role of a conserved, multifunctional RNA-binding protein, CUGBP1, in the development of aging phenotype in the liver.

  10. disruption of Celf1 gene is also responsible for a fully penetrant delayed first wave of spermatogenesis, and a delay of steroidogenesis may be the cause for the delay of germ cells differentiation

Zebrafish CUGBP, Elav-Like Family Member 1 (CELF1) interaction partners

  1. Results therefore suggest that Celf1 regulates proper organogenesis of endoderm-derived tissues by regulating the expression of such targets.

  2. Celf1-dependent fine-tuning of dmrt2a (show DMRT2 Proteins) expression is essential for generating bilateral symmetry of somites and left-right asymmetric patterning during zebrafish development.

  3. not only mRNA but also protein of brul is localized to the zebrafish germ plasm at the ends of the cleavage furrows

Xenopus laevis CUGBP, Elav-Like Family Member 1 (CELF1) interaction partners

  1. This "target protector and rescue assay" demonstrates that the phenotypic defects associated with CUGBP1 inactivation in Xenopus are essentially due to the deregulation of Su(H (show RBPJ Proteins)) mRNA.

CELF1 Protein Profile

Protein Summary

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with CELF1

  • CUGBP, Elav-like family member 1 (CELF1)
  • CUGBP, Elav-like family member 1 (Celf1)
  • cugbp, Elav-like family member 1 (celf1)
  • CUGBP, Elav-like family member 1 (celf1-a)
  • 1600010O03Rik protein
  • AA407467 protein
  • brul protein
  • Bruno-like protein
  • brunol2 protein
  • cb920 protein
  • cug-bp protein
  • cug-bp1 protein
  • cugbp protein
  • cugbp1 protein
  • cugbp1-a protein
  • D2Wsu101e protein
  • eden-bp protein
  • edenbp protein
  • HNAB50 protein
  • nab50 protein
  • NAPOR protein

Protein level used designations for CELF1

CUG triplet repeat, RNA binding protein 1 , CUGBP Elav-like family member 1 , 50 kDa nuclear polyadenylated RNA-binding protein , CELF-1 , CUG RNA-binding protein , CUG triplet repeat RNA-binding protein 1 , CUG triplet repeat, RNA-binding protein 1 , CUG-BP- and ETR-3-like factor 1 , CUG-BP1 , EDEN-BP homolog , RNA-binding protein BRUNOL-2 , bruno-like 2 , bruno-like protein 2 , deadenylation factor CUG-BP , embryo deadenylation element binding protein , embryo deadenylation element-binding protein homolog , nuclear polyadenylated RNA-binding protein, 50-kD , brain protein F41 , deadenylation factor EDEN-BP , EDEN-BP/Bruno-like protein , CELF-1A , CUG triplet repeat RNA-binding protein 1-A , CUG-BP- and ETR-3-like factor 1-A , CUG-BP1-A , CUGBP Elav-like family member 1-A , EDEN-BP-A , RNA-binding protein BRUNOL-2-A , bruno-like protein 2-A , embryo deadenylation element-binding protein A , p53/p55

GENE ID SPECIES
540475 Bos taurus
10658 Homo sapiens
13046 Mus musculus
362160 Rattus norvegicus
58137 Danio rerio
373923 Gallus gallus
399360 Xenopus laevis
100514512 Sus scrofa
100354668 Oryctolagus cuniculus
100730258 Cavia porcellus
101118301 Ovis aries
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