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Ca++-Dependent Secretion Activator 2 Proteins (CADPS2)

CADPS2 encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Additionally we are shipping CADPS2 Antibodies (16) and CADPS2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CADPS2 CADPS2 26989 Q62717
CADPS2 93664 Q86UW7
CADPS2 320405 Q8BYR5
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Top CADPS2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CADPS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Ca++-Dependent Secretion Activator 2 (CADPS2) Interaction Partners

Human Ca++-Dependent Secretion Activator 2 (CADPS2) interaction partners

  1. Mutation screening of 187 patients with autism spectrum disorders and 36 with intellectual disability identified a missense change of maternal origin disrupting CADPS2/D2DR (show DRD2 Proteins) interaction.

  2. We speculate that haploinsufficiency of CADPS2 contributes to ASDs.

  3. identification, cloning, and comparative characterization of a second mammalian CAPS (show CAPS Proteins) isoform, CAPS2 (show CAPS2 Proteins); concluded that at the functional level, CAPS2 (show CAPS2 Proteins) is largely redundant with CAPS1 (show CAPS Proteins)

  4. Results from Cadps2-deficient mice and human data suggest that a disturbance in CADPS2-mediated neurotrophin release contributes to autistic-like cellular and behavioral phenotypes.

  5. CAPS (show CAPS Proteins) proteins are involved in optimizing vesicular monoamine uptake and storage mediated by VMAT1 and VMAT2 (show Slc18a2 Proteins)

Mouse (Murine) Ca++-Dependent Secretion Activator 2 (CADPS2) interaction partners

  1. CAPS2 plays an important role in subcellular locality (axonal vs. somato (show SSTR5 Proteins)-dendritic) of enhanced BDNF (show BDNF Proteins) and NT-3 (show NTF3 Proteins) release, which is indispensable for proper development of postnatal cerebellum.

  2. Data suggest that adequate levels of CAPS2 are critical for normal brain development and normal behavior; allelic changes due to copy number variation may contribute to autistic behavior.

  3. Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF (show BDNF Proteins) and causes autistic-like behavior in mice

  4. identification, cloning, and comparative characterization of a second mammalian CAPS (show CAPS Proteins) isoform, CAPS2; concluded that at the functional level, CAPS2 is largely redundant with CAPS1 (show CAPS Proteins)

  5. results suggest that CAPS2 mediates the depolarization-dependent release of NT-3 (show NTF3 Proteins) and BDNF (show BDNF Proteins) from granule cells, leading to regulation in cell differentiation and survival during cerebellar development

  6. CADPS2-KO mice show autistic-like phenotypes. Moreover, the results show that some autistic patients have an aberrant splicing variant of CADPS2 mRNA, suggesting that a disturbance in CADPS2-mediated neurotrophin (show BDNF Proteins) release contributes to autism.

  7. CADPS2/CAPS2-knockout mice exhibit pronounced impairments in cerebellar development and functions. These results are also suggestive of an involvement of the CADPS2/CAPS2 gene, which is located within the AUTS1, in the cerebellar deficits of autism.

  8. The results show the immunohistochemical localization of the CAPS (show CAPS Proteins) family proteins in various mouse tissues.

  9. The two CAPS (show CAPS Proteins) family proteins are complementarily distributed throughout the various brain regions of mice.

CADPS2 Protein Profile

Protein Summary

This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CADPS2

  • Ca++-dependent secretion activator 2 (CADPS2)
  • Ca++-dependent secretion activator (Cadps)
  • Ca++-dependent secretion activator 2 (Cadps2)
  • Ca2+-dependent activator protein for secretion 2 (Cadps2)
  • A230044C21Rik protein
  • Caps protein
  • Caps-2 protein
  • Caps1 protein
  • Caps2 protein
  • Cpd2 protein
  • RGD1559440 protein

Protein level used designations for CADPS2

Ca2+-dependent activator protein for secretion 2 , Ca++-dependent secretion activator 2 , CAPS-1 , Ca2+-dependent activator protein , Ca2+-dependent secretion activator , Ca<2+-dependent activator protein for secretion , calcium-dependent activator protein for secretion 1 , calcium-dependent secretion activator 1 , rCAPS , CAPS-2 , calcium-dependent activator protein for secretion 2 , calcium-dependent secretion activator 2 , cerebellum postnatal development associated protein 2

GENE ID SPECIES
100056300 Equus caballus
472494 Pan troglodytes
26989 Rattus norvegicus
93664 Homo sapiens
312166 Rattus norvegicus
475304 Canis lupus familiaris
100525671 Sus scrofa
519444 Bos taurus
320405 Mus musculus
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