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CADPS2 encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Additionally we are shipping CADPS2 Proteins (3) and CADPS2 Kits (2) and many more products for this protein.
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Human Polyclonal CADPS2 Primary Antibody for EIA, IHC (p) - ABIN499527
Sadakata, Washida, Furuichi: Alternative splicing variations in mouse CAPS2: differential expression and functional properties of splicing variants. in BMC neuroscience 2007
Show all 3 references for ABIN499527
Human Polyclonal CADPS2 Primary Antibody for IHC, ELISA - ABIN1001982
Walent, Porter, Martin: A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells. in Cell 1992
Show all 3 references for ABIN1001982
Mutation screening of 187 patients with autism spectrum disorders and 36 with intellectual disability identified a missense change of maternal origin disrupting CADPS2/D2DR (show DRD2 Antibodies) interaction.
We speculate that haploinsufficiency of CADPS2 contributes to ASDs.
identification, cloning, and comparative characterization of a second mammalian CAPS (show CAPS Antibodies) isoform, CAPS2 (show CAPS2 Antibodies); concluded that at the functional level, CAPS2 (show CAPS2 Antibodies) is largely redundant with CAPS1 (show CAPS Antibodies)
Results from Cadps2-deficient mice and human data suggest that a disturbance in CADPS2-mediated neurotrophin release contributes to autistic-like cellular and behavioral phenotypes.
CAPS (show CAPS Antibodies) proteins are involved in optimizing vesicular monoamine uptake and storage mediated by VMAT1 (show SLC18A1 Antibodies) and VMAT2 (show Slc18a2 Antibodies)
CAPS2 plays an important role in subcellular locality (axonal vs. somato (show SSTR5 Antibodies)-dendritic) of enhanced BDNF (show BDNF Antibodies) and NT-3 (show NTF3 Antibodies) release, which is indispensable for proper development of postnatal cerebellum.
Data suggest that adequate levels of CAPS2 are critical for normal brain development and normal behavior; allelic changes due to copy number variation may contribute to autistic behavior.
Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF (show BDNF Antibodies) and causes autistic-like behavior in mice
identification, cloning, and comparative characterization of a second mammalian CAPS (show CAPS Antibodies) isoform, CAPS2; concluded that at the functional level, CAPS2 is largely redundant with CAPS1 (show CAPS Antibodies)
results suggest that CAPS2 mediates the depolarization-dependent release of NT-3 (show NTF3 Antibodies) and BDNF (show BDNF Antibodies) from granule cells, leading to regulation in cell differentiation and survival during cerebellar development
CADPS2-KO mice show autistic-like phenotypes. Moreover, the results show that some autistic patients have an aberrant splicing variant of CADPS2 mRNA, suggesting that a disturbance in CADPS2-mediated neurotrophin (show BDNF Antibodies) release contributes to autism.
CADPS2/CAPS2-knockout mice exhibit pronounced impairments in cerebellar development and functions. These results are also suggestive of an involvement of the CADPS2/CAPS2 gene, which is located within the AUTS1, in the cerebellar deficits of autism.
The results show the immunohistochemical localization of the CAPS (show CAPS Antibodies) family proteins in various mouse tissues.
The two CAPS (show CAPS Antibodies) family proteins are complementarily distributed throughout the various brain regions of mice.
This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.
Ca2+-dependent activator protein for secretion 2
, Ca++-dependent secretion activator 2
, Ca2+-dependent activator protein
, Ca2+-dependent secretion activator
, Ca<2+-dependent activator protein for secretion
, calcium-dependent activator protein for secretion 1
, calcium-dependent secretion activator 1
, calcium-dependent activator protein for secretion 2
, calcium-dependent secretion activator 2
, cerebellum postnatal development associated protein 2