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The protein encoded by CALCOCO2 is a subunit of nuclear domain 10 (ND10) bodies. Additionally we are shipping Calcium Binding and Coiled-Coil Domain 2 Proteins (8) and many more products for this protein.
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Human Polyclonal CALCOCO2 Primary Antibody for IP, WB - ABIN948915
Manzanillo, Ayres, Watson, Collins, Souza, Rae, Schneider, Nakamura, Shiloh, Cox: The ubiquitin ligase parkin mediates resistance to intracellular pathogens. in Nature 2013
Show all 2 references for ABIN948915
Presence of the NDP52 rs2303015 minor variant increases the risk for spontaneous bacterial peritonitis in patients with alcoholic cirrhosis.
insight into how CALCOCO2 targets ubiquitin-decorated pathogens for autophagic degradations
These data show that NDP52 promotes the maturation of autophagosomes via its interaction with LC3A (show MAP1LC3A Antibodies), LC3B (show MAP1LC3B Antibodies), and/or GABARAPL2 (show GABARAPL2 Antibodies) through a distinct LC3 (show MAP1LC3A Antibodies)-interacting region, and with MYOSIN VI (show MYO6 Antibodies).
data support a model in which non-ND10 resident Sp100 (show SP100 Antibodies) acts as a negative regulator of polycomb (show CBX2 Antibodies) repressive complex-2 (PRC2) recruitment, and suggest that KSHV may actively escape ND10 silencing mechanisms to promote establishment of latent chromatin.
two receptors previously linked to xenophagy, NDP52 and optineurin (show OPTN Antibodies), are the primary receptors for PINK1 (show PINK1 Antibodies)- and parkin (show PARK2 Antibodies)-mediated mitophagy
Dimeric NDP52 forms a ternary complex with two monomeric galectin-8 (show LGALS8 Antibodies) molecules as well as two LC3C (show MAP1LC3C Antibodies) molecules
The missense SNP rs2303015 (Val248Ala) in the NDP52 was associated with Crohn's disease.
Data indicate that the binding site in galectin-8 (show LGALS8 Antibodies) is essential for the recruitment of the autophagy receptor NDP52 to cytosol-exposed Salmonella Typhimurium.
Autophagy of Tax1bp1 (show TAX1BP1 Antibodies)/Ndp52 promotes non-canonical NF-kappaB (show NFKB1 Antibodies) signalling.
Data show that the selectivity of the autophagy receptor NDP52 for LC3C (show MAP1LC3C Antibodies) is crucial for innate immunity since cells lacking either protein cannot protect their
expression and association of NDP52 with autophagy-regulated gene proteins including LC3 (show MAP1LC3A Antibodies), as well as phosphorylated tau and amyloid-beta in brains of an Alzheimer disease model
The authors conclude that the dispersion of ND10 by major immediate-early (show JUN Antibodies) protein 1 (IE1) appears not to be important for murine cytomegalovirus replication in a mouse-cell culture.
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
calcium binding and coiled-coil domain 2
, Calcium-binding and coiled-coil domain-containing protein 2
, antigen nuclear dot 52 kDa protein
, calcium-binding and coiled-coil domain-containing protein 2
, nuclear domain 10 protein 52
, nuclear domain 10 protein NDP52
, nuclear dot protein 52
, nuclear domain 10 protein 52 like 1