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Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit Proteins (CACNA1D)

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Additionally we are shipping CACNA1D Antibodies (110) and CACNA1D Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CACNA1D 776 Q01668
Rat CACNA1D CACNA1D 29716 P27732
CACNA1D 12289 Q99246
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Top CACNA1D Proteins at antibodies-online.com

Showing 2 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

CACNA1D Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D) Interaction Partners

Zebrafish Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D) interaction partners

  1. Mutations in zebrafish cav1.3a underlie the auditory-vestibular defects of gemini (gem) circler mutants. gem mutant hair cells display normal cell viability, afferent synaptogenesis, and peripheral innervation, yet exhibit reduced extracellular potentials

Cow (Bovine) Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D) interaction partners

  1. new information on the hypothalamic expression of alpha1A and alpha1D subunits during development in a mammal with a long gestation period and a large and convoluted brain.

Human Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D) interaction partners

  1. LRP1B (show LRP1B Proteins), BRD2 (show BRD2 Proteins) and CACNA1D are new candidate genes in fetal metabolic programming of newborns exposed to maternal hyperglycemia.

  2. CACNA1D might not be a risk gene for SCZ in Han Chinese population, which add to the current state of knowledge regarding the susceptibility of CACNA1D to schizophrenia.

  3. patients with CACNA1D mutations displayed characteristics similar to wild-type aldosterone-producing adenomas

  4. Studies indicate the function of L-type calcium channels Cav1.3 in chromaffin cells.

  5. Studies indicate a role for L-type calcium channel Cav1.3 and Cav1.4 in cochlear inner hair cells (IHCs) and retinal photoreceptors (PRs).

  6. Mutations in CACNA1D gene is associated with aldosterone-producing adenomas.

  7. Different mutations (KCNJ5 (show KCNJ5 Proteins), ATP1A1 (show ATP1A1 Proteins), ATP2B3 (show ATP2B3 Proteins), and CACNA1D) are found in different aldosterone-producing nodules from the same adrenal, suggesting that somatic mutations are independent events triggered by mechanisms that remain to be identified.

  8. Study found that two de novo CACNA1D missense mutations affect evolutionary highly conserved regions in the channel's activation gate and disrupt normal channel activity by inducing a pronounced gain of channel function

  9. In overall, we provide evidence that Cav1.2 (show CACNA1C Proteins) and Cav1.3 isoforms are capable of potentially functioning as zinc permeation routes, through which zinc entry can be differentially augmented by mild acidifications.

  10. Cp8 is a new of Cav1.2 (show CACNA1C Proteins) and Cav1.3 channel activators.

Mouse (Murine) Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D) interaction partners

  1. implicating Cav1.3 as an essential element for hippocampus-associated cognitive functions

  2. Studies indicate the function of L-type calcium channels Cav1.3 in chromaffin cells.

  3. Data suggest that the ion channels CaV1.3, bestrophin-1 (show BEST1 Proteins) and maxiK (show KCNMA1 Proteins) were identified as players in the regulation of photoreceptor outer segments (POS) phagocytosis by the retinal pigment epithelium (RPE (show RPE Proteins)).

  4. Cp8 is a new of Cav1.2 (show CACNA1C Proteins) and Cav1.3 channel activators.

  5. RIM2alpha and RIM2beta promote a large complement of synaptic CaV1.3 Ca(2 (show CA2 Proteins)+) channels at inner hair cell presynaptic active zones and are required for normal hearing.

  6. Results indicate that the Cav1.3 subtype is crucial to regulation of basal single-spike firing, while activation of both Cav1.2 (show CACNA1C Proteins) and Cav1.3 can support burst firing of dopaminergic VTA neurons.

  7. ablation of Cav1.3 results in a decrease in the protein expression of myosin light chain 2, which interacts and increases the membrane localization of SK2 channels.

  8. These data demonstrate that type 1 diabetic serum hyperactivates both CaV1.2 (show CACNA1C Proteins) and CaV1.3 channels by increasing their conductivity and number.

  9. Cav1.3 significantly upregulated in brain 24hr after single nicotine injection; Cav1.2 (show CACNA1C Proteins) expression was not significantly altered; downregulation of Cav1.2 (show CACNA1C Proteins) 24hr after chronic nicotine administration; strong upregulation of Cav1.2 (show CACNA1C Proteins) following 7-day abstinence

  10. CaV1.3(-/-) RPE (show RPE Proteins) lacked peak phagocytic activity following morning photoreceptor shedding in wild-type RPE (show RPE Proteins) and retained a higher number of phagosomes at a later time of day.

CACNA1D Protein Profile

Protein Summary

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CACNA1D

  • calcium channel, voltage-dependent, L type, alpha 1D subunit, a (cacna1da)
  • calcium channel, voltage-dependent, L type, alpha 1D subunit (CACNA1D)
  • calcium channel, voltage-dependent, L type, alpha 1D subunit (cacna1d)
  • calcium channel, voltage-dependent, L type, alpha 1D subunit (Cacna1d)
  • 8430418G19Rik protein
  • C79217 protein
  • ca(v)1.3 protein
  • CACH3 protein
  • CACN4 protein
  • cacna1d protein
  • Cacnl1a2 protein
  • Cav1.3 protein
  • cav1.3a protein
  • Cchl1a protein
  • Cchl1a2 protein
  • D-LTCC protein
  • isl protein
  • SANDD protein
  • si:dz136d19.3 protein
  • si:dz223c6.1 protein

Protein level used designations for CACNA1D

L-type calcium channel pore subunit isoform 1.3a , gem , gemini , voltage-dependent L-type calcium channel subunit alpha-1D , voltage-gated calcium channel alpha 1D subunit , calcium channel, voltage-dependent, L type, alpha 1D subunit , voltage-gated calcium channel subunit Cav1.3 , calcium channel voltage-dependent L type Cav1.3, alpha 1d subunit , voltage-dependent L-type calcium channel subunit alpha-1D-like , calcium channel, L type, alpha-1 polypeptide , calcium channel, neuroendocrine/brain-type, alpha 1 subunit , voltage-gated calcium channel alpha 1 subunit , voltage-gated calcium channel alpha subunit Cav1.3 , CaV1.3alpha1 , RBD , brain class D , calcium channel alpha-1 subunit , voltage-dependent calcium channel subunit alpha1D , voltage-gated calcium channel pore forming subunit CaV1.3alpha1 IVS3-IVS4 extracellular linker , voltage-gated calcium channel subunit alpha Cav1.3 , Cav1.3alpha1 , alpha 1 E , CHCACHA1D , L-type voltage-gated calcium channel alpha1D subunit ChCaChA1D

GENE ID SPECIES
403310 Danio rerio
408013 Bos taurus
460447 Pan troglodytes
484724 Canis lupus familiaris
780391 Xenopus (Silurana) tropicalis
100135991 Oncorhynchus mykiss
100462912 Xenopus laevis
100511102 Sus scrofa
776 Homo sapiens
29716 Rattus norvegicus
12289 Mus musculus
395895 Gallus gallus
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