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Calcium Channel, Voltage-Dependent, L Type, alpha 1S Subunit Proteins (CACNA1S)

CACNA1S encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Additionally we are shipping CACNA1S Antibodies (54) and CACNA1S Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CACNA1S 779 Q13698
CACNA1S 12292  
Rat CACNA1S CACNA1S 682930  
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Top CACNA1S Proteins at antibodies-online.com

Showing 3 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CACNA1S Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Calcium Channel, Voltage-Dependent, L Type, alpha 1S Subunit (CACNA1S) Interaction Partners

Human Calcium Channel, Voltage-Dependent, L Type, alpha 1S Subunit (CACNA1S) interaction partners

  1. CACNA1S and SCN4A (show SCN4A Proteins) mutations are relatively rare in patients with hypokalemic periodic paralysis

  2. The authors found one and three rare variants of unknown significance in CACNA1S in the Malignant Hyperthermia and Exertional Heat cohorts

  3. Defects in the genes coding for the skeletal muscle ryanodine receptor and alpha 1 subunit of the dihydropyridine receptor (CACNA1S) have been identified as causative for malignant hyperthermia.

  4. Aberrant splicing of Cav (show CA5A Proteins) 1.1 may alter intracellular Ca(2 (show CA2 Proteins)+) signalling in myotonic dystrophy 1 and 2 myotubes. The differing dysregulation of intracellular Ca(2 (show CA2 Proteins)+) handling in DM1 (show DMPK Proteins) and DM2 (show CNBP Proteins) may explain their distinct sarcolemmal hyperexcitabilities.

  5. Exome sequencing revealed one rare cacna1s nonsynonymous variant in a family with malignant hyperthermia

  6. Data indicate that the presence of either one of these JP-45 (show JSRP1 Proteins) variants decreased the sensitivity of the dihydropyridine receptor DHPR (show QDPR Proteins) to activation.

  7. Affected members of a 5-generation Chinese family with hypokalemic periodic paralysis patients had a novel His916Gln mutation in all male HypoPP patients of the family. Penetrance of the mutation was complete in male carriers, but not female carriers.

  8. Misregulated splicing and altered gating of Ca(V)1.1 calcium channel is associated with muscle weakness in myotonic dystrophy.

  9. A novel mutation in the CACNA1S gene--p.Arg900Gly--is found in a patient with hypokalemic periodic paralysis; this mutation is subsequently found to affect some of the patient's other family members.

  10. All familial periodic paralysis patients studied have mutations in either CACNA1S or SCN4A (show SCN4A Proteins), but only 4 sporadic periodic paralysis patients have de novo mutations in CACNA1S (R1239H) and SCN4A (show SCN4A Proteins) (R669x2, R1135H).

Mouse (Murine) Calcium Channel, Voltage-Dependent, L Type, alpha 1S Subunit (CACNA1S) interaction partners

  1. Events occurring locally in the skeletal muscle of SOD1 mutant mice contribute to the impairment of CaV1.1 function in ALS muscle independently of innervation status.

  2. Knockdown of Cav1.1 channels in T cells abrogated calcium entry after TCR stimulation, suggesting that Cav1.1 channels are controlled by T cell receptor signaling

  3. Treatment of MSC (show MSC Proteins) with BMP4 (show BMP4 Proteins) caused a significant increase in expression of Cav1.2 (show CACNA1C Proteins), a delay in expression of Cav1.1, and a reduction in the duration of calcium transients when extracellular calcium was removed

  4. This study delineates a previously uncharacterized CaV1.1-mediated pathway that regulates energy utilization in skeletal muscle.

  5. Raptor (show RPTOR Proteins) ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex.

  6. amino-termini of Rad and Rem (show REM1 Proteins) as the structural elements dictating the specific modes of inhibition of CaV1.1

  7. the localization and stability of Cacna1s depend on the expression of mGluR6 (show GRM6 Proteins) and its cascade components, and they suggest that Cacna1s is part of the mGluR6 (show GRM6 Proteins) complex.

  8. This work demonstrates the critical role of the chloride gradient in modulating the susceptibility to ictal weakness and establishes bumetanide as a potential therapy for hypokalaemic periodic paralysis arising from either NaV1.4 (show SCN4A Proteins) or CaV1.1 mutations.

  9. Data propose a new role for Cav1.1 in the activation of signaling pathways allowing muscle fibers to decipher the frequency of electrical stimulation and to activate specific transcriptional programs that define their phenotype.

  10. Ca(2 (show CA2 Proteins)+) transients evoked by tetanic stimulation are the result of massive Ca(2 (show CA2 Proteins)+) influx due to enhanced Ca(v)1.1 channel activity, which restores muscle strength in JP45 (show JSRP1 Proteins)/CASQ1 (show CASQ1 Proteins) double knockout mice.

Pig (Porcine) Calcium Channel, Voltage-Dependent, L Type, alpha 1S Subunit (CACNA1S) interaction partners

  1. Results describe the cloning, sequencing and identification of single nucleotide polymorphisms of partial sequence on the porcine CACNA1S gene.

CACNA1S Protein Profile

Protein Summary

This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility.

Gene names and symbols associated with CACNA1S

  • calcium channel, voltage-dependent, L type, alpha 1S subunit (CACNA1S)
  • calcium channel, voltage-dependent, L type, alpha 1S subunit (cacna1s)
  • calcium channel, voltage-dependent, L type, alpha 1S subunit (Cacna1s)
  • AW493108 protein
  • ca(v)1.1 protein
  • CACNA1S protein
  • CACNL1A3 protein
  • caV1.1 protein
  • Cchl1a3 protein
  • fmd protein
  • HOKPP protein
  • HOKPP1 protein
  • hypoPP protein
  • mdg protein
  • MHS5 protein
  • sj protein
  • TTPP1 protein

Protein level used designations for CACNA1S

calcium channel, voltage-dependent, L type, alpha 1S subunit , voltage-dependent L type calcium channel alpha 1S subunit , voltage-dependent L-type calcium channel subunit alpha-1S , transverse tubule dihydropyridine receptor alpha 1 subunit , calcium channel, L type, alpha 1 polypeptide, isoform 3 (skeletal muscle, hypokalemic periodic paralysis) , dihydropyridine receptor , dihydropyridine-sensitive L-type calcium channel alpha-1 subunit , voltage-gated calcium channel subunit alpha Cav1.1 , calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle , DHPR alpha1s , dihydropyridine receptor alpha 1S , muscle dysgenesis , ROB1 , L-type calcium channel, alpha 1 subunit , voltage-gated calcium channel alpha 1S subunit

GENE ID SPECIES
469635 Pan troglodytes
490244 Canis lupus familiaris
654399 Felis catus
100034092 Equus caballus
100381134 Xenopus laevis
100734741 Cavia porcellus
779 Homo sapiens
100009585 Oryctolagus cuniculus
12292 Mus musculus
682930 Rattus norvegicus
395985 Gallus gallus
100286866 Sus scrofa
100337204 Bos taurus
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