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Calcium Channel, Voltage-Dependent, beta 4 Subunit Proteins (CACNB4)

CACNB4 encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Additionally we are shipping CACNB4 Antibodies (88) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CACNB4 785 O00305
CACNB4 12298 Q8R0S4
Rat CACNB4 CACNB4 58942  
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Top CACNB4 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CACNB4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4) Interaction Partners

Human Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4) interaction partners

  1. The nuclear targeting properties of the truncated beta(4b(1-481)) subunit in tsA (show PRDX2 Proteins)-201 cells, skeletal myotubes, and in hippocampal neurons, were investigated.

  2. Genome-wide association studies identify CACNB4 mutation releated to juvenile myoclonic epilepsy.

  3. Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy

  4. The Ca2 (show CA2 Proteins)+ channel beta4c subunit interacts with heterochromatin protein 1 gama via a PXVXL binding motif.

  5. CACNB4 is associated with acute lung injury in mice

  6. The novel nucleotide substitution T87C (D29D)in CACNB4 was observed in 2 migrainous vertigo patients and was not present in control DNA samples.

  7. No pathogenic mutation were identified in CACNB4.

  8. proband identified with severe myoclonic epilepsy in infancy heterozygous for de novo SCN1A (show SCN1A Proteins) nonsense mutation & CACNB4 missense mutation (R468Q); greater Ca(v)2.1 (show CACNA1A Proteins) currents caused by the mutation may increase neurotransmitter release in excitatory neurons

Mouse (Murine) Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4) interaction partners

  1. The nuclear targeting properties of the truncated beta(4b(1-481)) subunit in tsA (show PRDX2 Proteins)-201 cells, skeletal myotubes, and in hippocampal neurons, were investigated.

  2. Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy

  3. The Ca2 (show CA2 Proteins)+ channel beta4c subunit interacts with heterochromatin protein 1 gama via a PXVXL binding motif.

  4. Cacnb4 is associated with acute lung injury

  5. neither Ca(V)beta3 (show CACNB3 Proteins) nor Ca(V)beta4 are indispensable for hair cell Ca(2 (show CA2 Proteins)+) currents but contribute to the overall current properties

  6. Paroxysmal dyskinesias as well as absence epilepsy, chronic ataxia (show USP14 Proteins), and hypoactivity noted in the lethargic mouse mutant with CCHB4 gene mutation

CACNB4 Protein Profile

Protein Summary

This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CACNB4

  • calcium channel, voltage-dependent, beta 4 subunit (CACNB4)
  • calcium channel, voltage-dependent, beta 4 subunit (cacnb4.1)
  • calcium channel, voltage-dependent, beta 4 subunit (cacnb4)
  • calcium channel, voltage-dependent, beta 4 subunit (Cacnb4)
  • 3110038O15Rik protein
  • CAB4 protein
  • CACNB4 protein
  • CACNLB4 protein
  • Cchb4 protein
  • EA5 protein
  • EIG9 protein
  • EJM protein
  • EJM4 protein
  • EJM6 protein
  • lethargic protein
  • lh protein

Protein level used designations for CACNB4

calcium channel, voltage-dependent, beta 4 subunit , voltage-dependent L-type calcium channel subunit beta-4 , voltage-gated calcium channel beta 4.1 subunit , voltage-dependent L-type calcium channel subunit beta-4-like , calcium channel voltage-dependent subunit beta 4 , dihydropyridine-sensitive L-type, calcium channel beta-4 subunit , voltage-dependent calcium channel beta 4 subunit , CAB4 , calcium channel beta 4 subunit

GENE ID SPECIES
459660 Pan troglodytes
100019993 Monodelphis domestica
100192310 Oryzias latipes
100216182 Xenopus (Silurana) tropicalis
100393056 Callithrix jacchus
100597041 Nomascus leucogenys
374259 Gallus gallus
785 Homo sapiens
609361 Canis lupus familiaris
396585 Sus scrofa
12298 Mus musculus
58942 Rattus norvegicus
282161 Bos taurus
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