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binds actin stress fibers\; involved in actin bundling [RGD, Feb 2006].. Additionally we are shipping Calponin 1 Antibodies (268) and Calponin 1 Kits (25) and many more products for this protein.
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Actin cytoskeleton depolymerization inhibites BMP2 (show BMP2 Proteins) signaling via blocking of Smad (show SMAD1 Proteins) by dephosphorylated CNN1 in osteoblast cells under simulated microgravity.
These findings reveal a novel function of CNN1 in maintaining bone homeostasis by coupling bone formation to bone resorption
data suggest that in mice myometrium, phosphorylation of h1 calponin induced by the PKC-epsilon (show PRKCE Proteins) might facilitate the contraction of uterine in labor and regulate pregnant myometrial contractility.
A single intronic CArG element is necessary but insufficient for proper CNN1 expression in vivo. CNN1 overexpression antagonizes arterial injury-induced neointimal formation.
The structure of this functionally important region of calponin and its interaction with actin and calmodulin at amino-acid resolution, was mapped.
CNh1 plays a role as tumor suppressor in SR-3Y1 mainly by decreasing VEGF expression and angiogenesis in vivo and partially through reducing cellular proliferative potential and cell motility
Up-regulation of h1-calponin in SM-B null mice may be necessary to maintain reduced level of cross-bridge cycling over time in absence of SM-B myosin and play important role in regulating smooth muscle contraction.
Studied maternal serum calponin 1 levels in the prediction of delivery within 7 days among pregnancies complicated with threatened preterm labor. Of 73 women included in the study, found the maternal serum calponin 1 level was significantly high in women who delivered within 7 days vs. those who delivered after 7 days.
Loss of myoepithelial calponin was specifically associated with gain of the basal marker p63 (show RPE65 Proteins) in adjacent tumor cells.
Loss of CNN1 expression is associated with Ovarian Cancer.
CNN1 immunohistochemical staining allows ready recognition of intracytoplasmic inclusions, aiding diagnosis of infantile digital fibromatosis.
epsilonPKC/ERK (show EPHB2 Proteins)/mTOR (show FRAP1 Proteins) pathway activation induced by the rescued expression of CNN1 contributed to the improvement of cardiac dysfunction and pathological changes observed in transgenic mice.
Calponin-1 expression in the uterine smooth muscle tissue of the body and the lower uterine segment of smooth muscle tissues was significantly different.
Inhibition of calponin-1 expression can inhibit uterine smooth muscle cell migration and cause the morphological change and rearrangement of F-actin without affecting its proliferation and apoptosis in vitro.
D2-40 immunohistochemistry reliably identifies the myoepithelial cells of breast in a variety of lesions in a pattern similar to that of calponin and p63 (show RPE65 Proteins).
The point mutation S175T exhibited more resistance to actin rearrangement by cytochalasin D and PDBu than intact CNh1, suppressing cell motility induced by PDBu.
binds actin stress fibers\; involved in actin bundling
, basic calponin
, calponin H1, smooth muscle
, calponins, basic
, calponin 1, smooth muscle
, calponin alpha
, calponin, smooth muscle
, calponin 2 copy A
, smooth muscle calponin h1