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The protein encoded by CHST8 belongs to the sulfotransferase 2 family. Additionally we are shipping CHST8 Antibodies (37) and many more products for this protein.
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These findings, an allele frequency of 0.004357, and a 10-fold difference in prevalence of CHST8 (c.299 C > T, R77W) across different ethnic groups, suggest that this sequence represents a "passenger" distributed polymorphism, a simple sequence variant form of the enzyme having normal activity, rather than a "driver" disease-causing mutation that accounts for peeling skin syndrome
A missense mutation in the CHST8 gene, encoding GalNAc4-ST1, is the underlying cause of type A non-inflammatory peeling skin syndrome in this family.
analysis of enzymatic properties and expression of GalNAc-4-sulfotransferase-1 and GalNAc-4-sulfotransferase-2 (show CHST9 Proteins)
Significant differences in the allele, genotype and haplotype frequencies between BSE-affected and healthy cows indicate an association of sequence variant g.37254017G>T of CHST8 with the development of the disease in Brown Swiss cattle.
these findings indicate that the Chst8 transcript level affects the glycosaminoglycan environment of the cellular prion protein (show PRNP Proteins), and as a consequence its ability for conversion into PrP(Sc).
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene.
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
, carbohydrate sulfotransferase 8-like
, GalNAc-4-O-sulfotransferase 1
, N-acetylgalactosamine-4-O-sulfotransferase 1
, carbohydrate sulfotransferase 8
, carbohydrate N-acetylgalactosamine 4-0 sulfotransferase 8
, galNAc-4-O-sulfotransferase 1