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CARD14 encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Additionally we are shipping CARD14 Proteins (6) and many more products for this protein.
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Human Polyclonal CARD14 Primary Antibody for EIA, IHC (p) - ABIN1449966
Fanning, Anderson: Protein modules as organizers of membrane structure. in Current opinion in cell biology 1999
Show all 4 references for ABIN1449966
Human Polyclonal CARD14 Primary Antibody for WB - ABIN528893
Huh, Kim, Kim, Song, Jung, Jeong, Lee, Kim, Lee, An: Dysregulation of miR-106a and miR-591 confers paclitaxel resistance to ovarian cancer. in British journal of cancer 2013
The authors observations provide further insights into the genetics of psoriasis and functional information on novel CARD14 mutational variants seen in cases from Tunisia and other populations.
Genetic interactions of SNPs in CARD14, SENP1 (show SENP1 Antibodies) and VEGFA (show VEGFA Antibodies) might represent a functional mechanism in the pathogenesis of high altitude polycythemia.
analysis of 105 individuals with generalized pustular psoriasis (GPP) identified a low-frequency variant (p.Asp176His) that causes constitutive CARD14 oligomerization
CARD14 protein missense mutation found in patients diagnosed with psoriasis.
no definite causative genetic mutation in CARD14 as identified in familial pityriasis rubra pilaris after screening 8 non-familial patients of type I, type III and type IV pityriasis rubra pilaris
The study identified the DEP (show ZDHHC21 Antibodies) domain-containing protein DEPDC7 as cellular binding partner of CARMA2 and CARMA3 (show CARD10 Antibodies) proteins.
CARD14 mutation maybe responsible for activation of NF-kB signaling pathway in patients with pityriasis rubra pilaris.
Transfection of dermal ECs with psoriasis-associated CARD14 mutations resulted in increased expression of several chemokines, including CXCL10 (show CXCL10 Antibodies), IL-8 (show IL8 Antibodies), and CCL2 (show CCL2 Antibodies).
Variant analysis of CARD14 in a Chinese Han population with psoriasis vulgaris and generalized pustular psoriasis shows that CARD14 may play a role in the pathogenesis of generalized pustular psoriasis.
Owing to the relatively small number of cases analysed in this study, we cannot rule out the possibility that CARD14 mutations may be an exceptional cause of sporadic pityriasis rubra pilaris, as previously found in sporadic psoriasis
This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants.
CARD-containing MAGUK protein 2
, bcl10-interacting maguk protein 2
, card-maguk protein 2
, carma 2
, caspase recruitment domain-containing protein 14
, bcl10-interacting MAGUK protein 2