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CTSD encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally we are shipping Cathepsin D Kits (84) and Cathepsin D Proteins (57) and many more products for this protein.
Showing 10 out of 319 products:
Human Monoclonal Cathepsin D Primary Antibody for ELISA, EM - ABIN269482
Kitamura, Nakamura, Miyamoto, Miyamoto, Kabu, Yoshida, Futamura, Ichinose, Arakawa: Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria. in PLoS ONE 2011
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Human Monoclonal Cathepsin D Primary Antibody for WB - ABIN1882228
Burkard, Planyavsky, Kaupe, Breitwieser, Bürckstümmer, Bennett, Superti-Furga, Colinge: Initial characterization of the human central proteome. in BMC systems biology 2011
Show all 4 references for ABIN1882228
Human Monoclonal Cathepsin D Primary Antibody for IF, IP - ABIN968183
Erickson, Conner, Blobel: Biosynthesis of a lysosomal enzyme. Partial structure of two transient and functionally distinct NH2-terminal sequences in cathepsin D. in The Journal of biological chemistry 1981
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Human Polyclonal Cathepsin D Primary Antibody for EIA, WB - ABIN951064
Albayrak, Tirniceriu, Riemenschneider, Kurz, Scherag, Egensperger: The cathepsin D (224C/T) polymorphism confers an increased risk to develop Alzheimer's disease in men. in The journals of gerontology. Series A, Biological sciences and medical sciences 2010
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Human Monoclonal Cathepsin D Primary Antibody for EIA, IHC (p) - ABIN317502
Fusek, Vetvicka: Dual role of cathepsin D: ligand and protease. in Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005
Show all 2 references for ABIN317502
Human Polyclonal Cathepsin D Primary Antibody for IHC (fro), IHC (p) - ABIN115287
Henry, McCarthy, Angus, Westley, May, Nicholson, Cairns, Harris, Horne: Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study. in Cancer 1990
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Human Polyclonal Cathepsin D Primary Antibody for IF (p), IHC (p) - ABIN732098
Liao, Li, Li, Liu: Organellar proteome analyses of ricin toxin-treated HeLa cells. in Toxicology and industrial health 2014
These results suggest that the ecdysone response elements are vital for activation of the promoter by 20-hydroxyecdysone (20E) in the larval fat body and further support the crucial role of ecdysone signaling to control cathepsin D gene transcription.
Fibroblasts from Niemann-Pick type C (NPC (show NPC1 Antibodies)) disease patients with low levels of NPC1 (show NPC1 Antibodies) protein have high amounts of procathepsin D but reduced quantities of the mature protein, thus showing a diminished cathepsin D activity.
Data indicate that cathepsin D (CD) protein is elevated in the retinas of diabetic mice and serum of human patients with diabetic macular edema (DME).
Data show that co-silencing of tricho-rhino-phalangeal-syndrome (TRPS1 (show TRPS1 Antibodies)) and cathepsin D (Cath-D) in breast cancer cells (BCC) affects the transcription of cell cycle and proliferation.
Transcellular transmission of alpha-synuclein (show SNCA Antibodies) aggregates is increased in CTSD mutated cells.
Serum CatD activity as a marker of healthy endogenous phagocytosis and remodeling was impaired in patients with new-onset cardiac dysfunction.
study provides evidence that hTERT overexpression is responsible for the upregulation of the cysteine protease (show CTSB Antibodies) cathepsin D by regulating EGR-1 (show EGR1 Antibodies) to activate invasiveness in cancer progression
A proteomics workflow identified CTSD as an over-expressed protein in osteosarcomas and pulmonary metastases and may thus serve as a new biomarker for individualized treatment regimes for patients with osteosarcomas, even at metastastic stage.
the clues provided by the yeast model unveiled a novel CatD function in the degradation of damaged mitochondria when autophagy is impaired, which protects colorectal cancer cells from acetate-induced apoptosis.
Fenhexamid and cyprodinil can promote ovarian cancer metastasis by increasing the protein expression of cathepsin D via an estrogen receptor (show ESR1 Antibodies) dependent pathway.
Variations in CTSD and MnSOD (show SOD2 Antibodies) showed no association with the development of Alzheimer's Disease, whereas the presence of the Ala224Val polymorphism in CTSD had a positive association with the development of AD
This study demonistrated that Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
Post-translational modifications drive CatD into the nucleus to cleave Histone 3 in the involuting mammary gland.
Increased lysosomal storage in CatD KO mice causes oxidative damage in brain pericytes, subsequently resulting in an increased vessel diameter and enhanced permeability of the BBB (show ALMS1 Antibodies).
Mouse prolactin (show PRL Antibodies) was proteolytically cleaved by Cath D between amino acids 148 and 149. N-terminal prolactin (show PRL Antibodies) fragment and Cath D expression increased during mammary gland involution.
Cathepsin D was not inherent to sperm themselves, but rather of epididymal origin and was presumably transported to the sperm surface via epididymosomes.
TGase 2 (show TGM2 Antibodies) may regulate the balance between cell survival and cell death through the modulation of CTSD levels.
These results suggest that increased release/activation of cathepsin D can trigger neurodegeneration and possibly development of Niemann-Pick type C disease pathology.
Relative position of thyroglobulin (Tg (show TG Antibodies))peptide epitopes are identified based on homology to known Ctsd cleavage sites in rabbit Tg.
Three cathepsin D-specific cleavage sites in Bid (show BID Antibodies), Phe24, Trp48, and Phe183, were identified.
Association of polymorphisms in calpain 1 (show CAPN1 Antibodies), (mu/I) large subunit, calpastatin (show CAST Antibodies), and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle.
findings strongly suggest a link between the lysosomal dysfunction of cathepsin D and the etiology of Alzheimer's disease
The effect of heavy metal cations on the activity of cathepsin D, was studied.
This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.
, cathepsin D
, aspartic protease
, cathepsin d
, preprocathepsin D
, ceroid-lipofuscinosis, neuronal 10
, lysosomal aspartyl peptidase
, lysosomal aspartyl protease
, cathepsin D (lysosomal aspartyl peptidase)
, cathepsin D (lysosomal aspartyl protease)
, prepro-cathepsin D, prepro-CD